Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm

• Project/Area Number: 24592337
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka University
• Principal Investigator: UETA kazuyoshi 大阪大学, 医学(系)研究科(研究院), 助教 (90432533)
• Co-Investigator(Kenkyū-buntansha): IGUCHI Naoya 大阪大学, 大学院医学系研究科, 助教 (00372623)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 急性腎障害 / NGAL / バイオマーカー / 大動脈ステント手術 / 腎不全 / L-FABP

Outline of Final Research Achievements

Acute kidney injury (AKI) is a common and serious condition usually detected some time after onset by changes in serum creatinine (sCr). Although stent grafting to repair aortic aneurysms is associated with AKI caused by surgical procedures or the use of contrast agents, early biomarkers for AKI have not been examined in stent graft recipients. We studied early biomarkers for AKI in patients who had received stent graft repairs of aortic aneurysms.
6 (14%) of 42 retained patients developed AKI. NGAL corrected with urine Cr (NGAL/Cr) values demonstrated the best predictive value for AKI (97% specificity, 83% sensitivity at a 65.1microg/gCr cutoff). Although NGAL/Cr, L-FABP/Cr, L-FABP, NAG, Alb/Cr all reached peak values before AKI detection by sCr in AKI patients, all biomarkers reached cut off value before AKI detection after adaption of cut off value. After stent graft repair of aortic aneurysm, NGAL/Cr is a potentially useful early biomarker for AKI.

Research Products

• [Journal Article] Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm: a prospective observational study (2014)
  • Author(s): Kazuyoshi Ueta, Michiko Watanabe, Naoya Iguchi, Akinori Uchiyama, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa, Yuji Fujino
  • Journal Title: Journal of Intensive Care Volume: 2:45 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s40560-014-0045-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] THE RATIO AND RISK FACTORS OF POST-ANESTHETIC SHIVERING WITH REMIFENTANIL IN PATIENTS UNDERGONE CARDIAC SURGERY: A RETROSPECTIVE STUDY (2015)
  • Author(s): Ueta, T. Tamura, Y. Hayashi, A. Uchiyama1, Y. Fujino
  • Organizer: IARS
  • Place of Presentation: アメリカ（ホノルル）
  • Year and Date: 2015-03-21 – 2015-03-24
• [Presentation] NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AS AN EARLY BIOMARKER FOR ACUTE KIDNEY INJURY AFTER ENDOVASCULAR STENT GRAFT REPAIR OF AORTIC ANEURYSM. (2012)
  • Author(s): K Ueta, N Watanabe, N Iguchi, A Uchiyama, K Hosotsubo, Y Fujino.
  • Organizer: European Society of Intensive Care Medicine
  • Place of Presentation: Lisbon