A study of the perioperative glycemic control method using pharmacological activity of GLP-1
| Project/Area Number |
24592340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kochi University |
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Principal Investigator |
KAWANO Takashi 高知大学, 教育研究部・医療学系, 講師 (40380076)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Masataka 高知大学, 教育研究部医療学系, 教授 (20158380)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グルカゴン様ペプチド-1 / インスリン / 全身麻酔薬 / 血糖管理 / 周術期 / 糖尿病 / 吸入麻酔薬 / グルカゴン様ペプチド / イソフルラン / プロポフォール / デクスメデトミジン / インスリン分泌 / 静脈麻酔薬 / グルコース / 耐糖能異常 / 膵島灌流試験 |
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| Outline of Final Research Achievements |
Glucagon-like peptide-1 (GLP-1) is known to increase insulin secretion and play a crucial role in maintaining glucose homeostasis. In this study, we performed both in vivo and in vitro experiments to evaluate the interaction between GLP-1 and general anesthetics in rats. Our findings can be summarized as follows: 1) Inhalation of isoflurane led to a decrease in the basal levels of GLP-1. 2) Isoflurane attenuated the glucose-evoked increase in the levels of GLP-1 and insulin and increased the plasma glucose levels. 3) During oral glucose tolerance test, dexmedetomidine inhibited glucose-induced insulin secretion in dose-dependent manner. 3) In perifusion experiments, isoflurane inhibited glucose-induced insulin release, whereas exogenous GLP-1 enhanced it. 4) Whole-cell patches showed that GLP-1 could restore the glucose-stimulated depolarization suppressed by isoflurane. 5) Propofol has no effect on the GLP-1 release from intestinal L cells.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] Effects of Propofol on Secretion and Insulinotropic Efficiency of Glucagon-Like Peptide-1: An In Vitro Study2013
Author(s)
Daiki Yamanaka, Takashi Kawano, Haidong Chi, Kentaro Yamamoto, Yori Inoue, Tomoka Eri, Mitsuki Fukuta, Rie Ihara, Masataka Yokoyama, Satoru Eguchi
Organizer
American Society of Anesthesiology, 2013 Annual meeting
Place of Presentation
San Francisco
Related Report
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