| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The aim of this project was to investigate whether hydrogen sulfide exerts cardioprotective effects against myocardial dysfunction due to endotoxin-induced systemic inflammation, and to elucidate the biological and molecular mechanisms of action. We sought to examine the optimal conditions toward administration of several hydrogen sulfide donors as well as induction of systemic inflammation. In addition, we investigated the experimental conditions in vitro as well as in vivo. We could not clear the proposal, however, during the period of this project probably due to lack of seeking optimal condition against the endotoxin-induced systemic inflammation. We continue to proceed to demonstrate organ-protective effects of hydrogen sulfide proposed in this project in other ways.
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