Effect of inhaled anesthetics on recovery after brain infarction.

• Project/Area Number: 24592343
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyushu University
• Principal Investigator: AKIYOSHI KOZABURO 九州大学, 大学病院, 講師 (70322287)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 脳梗塞 / 脳保護 / 免疫 / 全身麻酔薬 / 吸入麻酔 / 免疫抑制 / 免疫反応 / 脳保護作用

Outline of Final Research Achievements

The purpose of this study was to clarify the effects of the immunosuppressive effects and brain protective effects of general anesthetics. To this, we planed, 1) experiment on the cultured cell for the relevance of the inhalation anesthetics, isoflurane and sevoflurane, for the brain protective effect and the inflammatory response suppression. 2) experiment of the impact of inhalation anesthetics on the brain infarct size and functional prognosis using a mouse brain infarction model. 3) experiment of the effects of anesthetic on the microglia function, which is responsible for mainly immune defense in the brain.