| Project/Area Number |
24592348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
TERUYA KOUJI 琉球大学, 医学(系)研究科(研究院), 助教 (50437985)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIRO Masakatsu 琉球大学, 医学部附属病院, 助教 (00315483)
FUCHIGAMI Tatsuya 琉球大学, 医学部附属病院, 講師 (10381211)
KAMIZATO Kota 琉球大学, 医学部附属病院, 助教 (10554454)
KAKINOHANA Manabu 琉球大学, 大学院医学研究科, 教授 (20274897)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 敗血症 / 硫化水素 / 炎症性サイトカイン / HMGB1 / 臓器障害 / アポトーシス / 肝臓 |
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| Outline of Final Research Achievements |
We investigated whether inhalation of hydrogen sulfide could prevent septic condition after LPS administration in mice. Our results showed that inhalation of hydrogen sulfide could improve survival rate and completely suppress expression of inflammatory cytokine after LPS administration in mice. And inhalation of hydrogen sulfide was able to inhibit transition of HMGB1 from nuclei into cytoplasm. Our results suggested that inhalation of hydrogen sulfide might potentially improve survival rate via inhibition of cytokine expression during sepsis.
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