Study on the relationship between metallothionein-deficiency and pain in CRPS
| Project/Area Number |
24592351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 複合性局所疼痛症候群 / CRPS / メタロチオネイン / 酸化ストレス / 神経障害性疼痛 / 神経傷害性疼痛 |
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| Outline of Final Research Achievements |
Metallothioneins (MT) are low molecular weight (6-7 kDa) metal binding proteins. We previously reported that MT-I/II defected in the injured peripheral nerve from the patients with complex regional pain syndrome (CRPS)-2 and painful neuroma using a proteomics approach. CRPS is a chronic pain disorder displayed a characteristics of neuropathic pain, which is caused by nerve injury or diseases, such as cancer or diabetes. Here, we revealed that MTs were decreased in the injured nerve of neuropathic pain model rats generated by partial ligation of sciatic nerve and that administration of the recombinant human MT-IIA to the periphery of ligation site of model rats improved painful behavior. These results suggest that MT in injured peripheral nerve contributes to neuropathic pain.
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Report
(4 results)
Research Products
(10 results)
