| Project/Area Number |
24592354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IBUKI Takae 京都府立医科大学, 医学(系)研究科(研究院), 講師 (90232587)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Kiyoshi 大阪工業大学, 工学部, 教授 (10157349)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腰痛 / プロスタグランジン / 炎症 / 椎間板性腰痛 / 遺伝子 / 椎間板 / 後根神経節 / シクロオキシゲナーゼ / 髄核 / プロスタグランジンE2 / アラキドン酸カスケード / プロスタグランディン |
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| Outline of Final Research Achievements |
Lifetime susceptibility of lumbar pain among Japanese people is approximately 85% and prompt measures need to be taken. In this study, we tried to elucidate mechanism of lumbar discogenic pain focusing on prostaglandin (PG) synthesis and inflammatory cytokines. COX-1 was strongly expressed in the lumbar discs and neighboring tissues and its expression did not change following disc puncture. COX-2 was not expressed in normal animals, but strong expression was observed in punctured disc and surrounding tissues 24 hours following disc puncture. Using peripheral inflammatory pain model, we found that PG synthesis is dependent on COX-2 and mPGES-1 expression and iPLA2 is involved in the expression of COX-2. Further, behavioral hyperalgesia was correlated with expression of PG synthesis in peripheral inflammatory pain model. Involvement of PG synthesis in lumbar discogenic pain would be elucidated.
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