Prevention of neuropathic pain by antidepressants and anticonvulsants: in vivo patch-clamp analysis
| Project/Area Number |
24592355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka City University |
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Principal Investigator |
MORI Takashi 大阪市立大学, 医学(系)研究科(研究院), 准教授 (00336786)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | インビボパッチクランプ法 / トラマドール / 神経障害性疼痛 / 予防法 / 予防効果 / 抗うつ薬 / 抗痙攣薬 |
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| Outline of Final Research Achievements |
The purpose of the present research was to investigate the mechanisms of neuropathic pain and preventive effects of drugs by using in vivo patch-clamp technique in rat spinal dorsal horn and behavioral experiments. However, contrary to expectations, the synaptic property of substantia gelatinosa neurons in neuropathic pain model rat have not been clarified by the electrophysiological technique. In behavioral study, continuous intraperitoneal infusion of tramadol, dexmedetomidine, pravastatin and ketamine before the nerve injury had no preventive effect on neuropathic pain. Some preventive effects were observed by ropivacaine administered locally on ligated nerve. Further study will be needed to confirm this preventive effects. Our in vivo patch-clamp experiments revealed that systemic tramadol modulated the synaptic activities of substantia gelatinosa neurons in the spinal cord and indicated that metabolite M1 may play a key role in the antinociceptive mechanisms of tramadol.
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Report
(4 results)
Research Products
(18 results)
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[Presentation] The impact of intraoperative hypothermia on early postoperative adverse events after esophagectomy.2012
Author(s)
Hiroyuki Yamasaki, Katsuaki Tanaka, Yusuke Funai, Koichi Suehiro, Mitsuyo Nakamura, Taku Hamada, Tomoharu Funao, Ichiro Hase, Takashi Mori, Kiyonobu Nishikawa
Organizer
2012 Annual Meeting, American Society of Anesthesiologists
Place of Presentation
Walter E. Washington Convention Center, Washington DC, USA
Related Report
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