| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Effect of micro-RNA on channel remodeling in atrial cardiac myocyte on atrial fibrillation in septic condition was investigated. Septic condition was induced by the injection of lipopolysaccharide, and in this model, expression of L-type calcium channel was inhibited, but expression of delayed rectified potassium channel was enhanced. At the same time, expression of inducible nitric oxide was enhanced. In the blood, micro particles that contain micro RNA were observed, but direct relationship between micro-RNA and channel remodeling could not find. It was suspected that channel remodeling in septic condition might be a direct effect of inflammatory cytokines.
|
