Preventing effect of hydroxyethyl starch solution on endothelial glycocalyx under injury

• Project/Area Number: 24592365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hyogo Medical University
• Principal Investigator: TATARA Tsuneo 兵庫医科大学, 医学部, 教授 (30207039)
• Co-Investigator(Renkei-kenkyūsha): UEKI Ryusuke 兵庫医科大学, 医学部, 講師 (10340986)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 代用血漿製剤 / グリコカリックス / 血漿増量効果 / 手術 / ヒドロキシエチルデンプン / ゲル / ゲル構造

Outline of Final Research Achievements

Hydroxyethyl starch (HES) solution is a most widely used plasma substitute to treat hypovolemia during perioperative period. This study investigated the effects of HES on the endothelial glycocalyx structure using polyacrylamide gel. We also analyzed these effects and plasma volume expanding effects of HES during surgery. It was found that HES decreased permeability of polyacrylamide gel. On the other hand, plasma volume expanding effects of HES during surgery were inconsistent. These findings suggest that HES modulates permeability of endothelial glycocalyx by changing structure of endothelial glycocalyx.

Research Products

• [Journal Article] Physical plugging does not account for attenuation of capillary leakage by hydroxyethyl starch 130/0.4: A synthetic gel layer model. (2013)
  • Author(s): Tatara T., Itani M, Sugi T, Fujita K
  • Journal Title: J Biomed Mater Res Part B Volume: 101B Issue: 1 Pages: 85-90
  • DOI: 10.1002/jbm.b.32819
  • Peer Reviewed
• [Journal Article] Extracellular fluid accumulation predicts fluid responsiveness after hydroxyethyl starch 70/0.5 bolus infusion during major abdominal surgery. (2013)
  • Author(s): Ide T, Tatara T, Kaneko T, Nishi S
  • Journal Title: Open Journal of Anesthesiology Volume: 3 Issue: 09 Pages: 413-420
  • DOI: 10.4236/ojanes.2013.39087
  • Peer Reviewed
• [Presentation] 周術期輸液のサイエンス (2015)
  • Author(s): 多田羅恒雄
  • Organizer: 地域連携セミナー（東邦大学医療センター大森病院 麻酔科）
  • Place of Presentation: 東京
  • Year and Date: 2015-03-14
• [Presentation] Why not? Goal-directed fluid therapy (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 第76回日本臨床外科学会総会
  • Place of Presentation: 郡山
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] 侵襲時のHES その光と影 (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 第4回麻酔科フォーラム in TOYAMA
  • Place of Presentation: 富山
  • Year and Date: 2014-10-24
  • Invited
• [Presentation] Why not? Goal-directed fluid therapy (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 日本麻酔科学会 第4回北海道・東北支部学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-13
  • Invited
• [Presentation] 侵襲時のHES その光と影 (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 高知麻酔・集中治療セミナー
  • Place of Presentation: 高知
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] Why not? Goal-directed fluid therapy (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 第79回新潟麻酔科懇話会
  • Place of Presentation: 新潟
  • Year and Date: 2014-06-07
  • Invited
• [Presentation] Why not? Goal-directed fluid therapy (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 第2回周術期循環・呼吸セミナー in Fukuoka
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-24
  • Invited
• [Presentation] 侵襲時輸液のサイエンス (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 日本麻酔科学会第61回大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] 侵襲時のHES その光と影 (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 愛宕麻酔研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-26
  • Invited
• [Presentation] 侵襲時のHES その光と影 Part 1: What timing? (2014)
  • Author(s): 多田羅恒雄
  • Organizer: 第29回体液・代謝管理研究会年次学術集会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] HES その光と影 (2013)
  • Author(s): 多田羅恒雄
  • Organizer: 川崎北部周術期輸液栄養研究会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] What timing? 晶質液 vs. 膠質液 (2013)
  • Author(s): 多田羅恒雄
  • Organizer: 第11回周術期体液・代謝・侵襲研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 侵襲時のHES その光と影 (2013)
  • Author(s): 多田羅恒雄
  • Organizer: 第4回麻酔周術期医学講演会
  • Place of Presentation: 京都
  • Invited
• [Book] 症例で学ぶ新しい周術期の輸液管理 (2014)
  • Author(s): 多田羅恒雄
  • Total Pages: 6
  • Publisher: メディカル・サイエンス・インターナショナル