Non-invasive blood pressure monitoring via pulse transit time between ECG R wave and carotid

• Project/Area Number: 24592367
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kawasaki Medical School
• Principal Investigator: Fujita Yoshihisa 川崎医科大学, 医学部, 教授 (10144263)
• Research Collaborator: HIRAO Yoichi ; TSUJI Marina
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 血圧測定 / モニター / ドップラー / 脈波伝搬時間 / 血圧 / 非侵襲的モニター / 生体情報監視装置 / 非侵襲モニター / 脈波伝搬速度 / ドップラー血流計 / 非侵襲的血圧計測 / 無侵襲動脈圧モニター / 超音波

Outline of Final Research Achievements

We examined the validity of our pressure monitoring system by comparing PTT derived systolic blood pressure (Dopp_SBP) with invasive radial systolic arterial pressure (Inv_SBP) with calibration every 15 min in the ICU setting. Carotid arterial flow via an 8-MHz Doppler probe, ECG, and radial arterial pressure signals were transferred to a personal computer at a rate of 1 kHz and processed to calculate Dopp_SBP from PTT using our own formula.
Results & conclusions:Inv_SBP ranged from 213 to 82 mmHg, and Dopp_SBP from 185 to 71 mmHg. The Bland-Altman plot of the comparison between Inv_SBP and Dopp_SBP revealed limits of agreement of -20.1 to 17.7 mmHg (mean difference, -1.2 mmHg). There was a significant close linear correlation between Inv_SBP and Dopp_SBP (y=0.95x + 7.51, R2=0.84, p<0.0001).The results of the study show that our system is feasible for systolic blood pressure tracking over a longer interval if it is combined with intermittent calibration.

Research Products

• [Journal Article] Noninvasive tracking of systolic arterial blood pressure using pulse transit time measured with ECG and carotid doppler signals with intermittent calibration (2016)
  • Author(s): Fujita, Yoshihisa
  • Journal Title: Anesthesia and Resuscitation Volume: 52 Pages: 25-28
  • NAID: 120005741266
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Experimental validation of blood flow derived from pulse oximeter wave signals in beagles (2015)
  • Author(s): Masako Yamamoto, Yoshihisa Fujita, Yuka Sakuta, Masatsugu Tsuge.
  • Journal Title: Kawasaki Medical Journal Volume: 41 Pages: 1-5
  • DOI: 10.11482/KMJ-E41(1)1
  • NAID: 110009926231
  • ISSN: 0385-0234, 2434-3404
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Experimental validation of blood flow derived from pulse oximeter wave signals in beagles. (2015)
  • Author(s): Masako Yamamoto, Yoshihisa Fujita, Yuka Sakuta and Masatsugu Tsuge
  • Journal Title: Kawasak Medical Journal Volume: 41(1) Pages: 1-4
  • NAID: 110009926231
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 頸動脈ドップラーを用いた動脈圧モニターの試み (2014)
  • Author(s): 平尾拓一，辻 真莉奈，藤田喜久
  • Journal Title: 麻酔・集中治療とテクノロジー 2013 Volume: 1 Pages: 55-58
  • Open Access
• [Presentation] Noninvasive tracking of systolic arterial blood pressure using pulse transit time measured with ECG and carotid Doppler signals with intermittent calibration. (2015)
  • Author(s): Fujita Y., Sakuta Y., Tsuge M., Sugimoto E., Nakatsuka H.
  • Organizer: European Society of Anesthesiologists 2015 Annual meeting
  • Place of Presentation: Berlin/ Germany
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Noninvasive tracking of systolic arterial blood pressure using pulse transit time measured with ECG and carotid Doppler signals with intermittent calibration (2015)
  • Author(s): 藤田喜久、杉本悦子
  • Organizer: Annual meeting of European Society of Anesthesiologists 2015
  • Place of Presentation: Citycube Berlin, Germany
  • Year and Date: 2015-05-29 – 2015-06-02
• [Presentation] 頸動脈ドップラーを用いた動脈圧モニターの試み (2012)
  • Author(s): 平尾 拓一、辻真莉奈、藤田喜久
  • Organizer: 第30回日本麻酔・集中治療テクノロジー学会
  • Place of Presentation: 鹿児島市民文化ホール （鹿児島市）
• [Presentation] Correlation of Arterial Blood Pressure With Pulse Transit Time Measured Using ECG and Carotid Doppler Signals.
  • Author(s): Yoshihisa Fujita, M.D.,Ph.D., Motohiko Hanazaki, M.D.,Ph.D., Keita Hazama, M.D., Nami Yoshitake, M.D., Etsuko Sugimoto, M.D.
  • Organizer: Annual meeting 2013, American Society of Anesthesiologists
  • Place of Presentation: San Francisco, U.S.A.