Transeesophageal spinal echography and platelet activity

• Project/Area Number: 24592368
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyushu Dental College
• Principal Investigator: WATANABE Seiji 九州歯科大学, 歯学部, 教授 (10201196)
• Co-Investigator(Kenkyū-buntansha): MISHIMA Yasunori 久留米大学, 医学部麻酔学講座, 准教授 (30258476) ; 三島 康典 久留米大学, 医学部, 准教授 (30258470)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 血小板機能 / 経食道エコー / 脊髄解剖 / 血小板凝集能 / 遅発型脊髄虚血 / フルルビプロフェン / 遅発性脊髄虚血 / 活性化血小板 / 血管内皮障害 / 経食道心臓超音波検査 / ＮＳＡＩＤｓ

Outline of Final Research Achievements

The detail of spinal structure can be seen through the spinal disk with the transesophageal echography.However, the range of view was limitted below the 1st lumbar windows through spinal disk. Augmentation of area supplied by the spinal artery was not seen with the contrast echography. Transesophageal spinal echography was useful for the diagnosis of the spinal ischemia.
The patients discontinued with antiplatelet therapy may be exposed to a risk of thrombotic events wich coukd cause the delayed spinal ischemia. The aim of this study is to evaluate the antiplatelet effect of flurbiprofen in patients who underwent surgery. Our preliminary data demonstrated that flurbiprofen inhibited platelet aggregation induced by collagen. Nonsteroidal anti-inflammatory drugs may include the possibility of temporary replacement of aspirin. Our findings showed that the administration of flurbiprofen can inhibit platelet aggregation and maybe useful to avoid the delayed spinal ischemia.

Research Products

• [Presentation] 全身麻酔中のフルルビプロフェン投与による血小板凝集能変化 (2014)
  • Author(s): 伊藤明日香、渡邉誠之、牛島一男
  • Organizer: 日本麻酔科学会第61回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] The Effects of Intraoperative Administration of Flurbiprofen on the Platelet Functions in Patients Undergoing General Anesthesia (2013)
  • Author(s): Asuka Ito, Seiji Watanabe、Yasunori Mishima, Shuhei Niiyama
  • Organizer: American Society of Anesthesiologists
  • Place of Presentation: San Francisco、USA