Diet-induced macrophage inhibitory cytokine 1 and prostate cancer progression.

• Project/Area Number: 24592374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Akita University
• Principal Investigator: HUANG Mingguo 秋田大学, 医学(系)研究科(研究院), 助教 (60448503)
• Co-Investigator(Kenkyū-buntansha): NARITA Shintaro 秋田大学, 大学院医学系研究科, 講師 (40396552) ; TSUCHIYA Norihiko 秋田大学, 大学院医学系研究科, 准教授 (70282176)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: prostate cancer / high-fat diet / palmitic acid / MIC-1 / 前立腺がん / FASN / high fat diet / 前立腺癌

Outline of Final Research Achievements

In the present study, high-fat diet (HFD) containing Palmitic acid (PA) promoted growth and invasiveness of prostate cancer (PCa) cells through the upregulation of MIC1 expression. In addition, HFD modulates fatty acid synthase (FASN) expression, which may be an important mechanism in HFD-associated PCa progression.

Research Products

• [Journal Article] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression (2014)
  • Author(s): Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
  • Journal Title: Endocr Relat Cancer Volume: 21 Issue: 1 Pages: 39-50
  • DOI: 10.1530/erc-13-0227
  • Peer Reviewed
• [Presentation] High-fat diet alters phosphatidylinositol profile and tumor growth in the LNCaP xenograft mice (2014)
  • Author(s): 小泉淳、黄明国、成田伸太郎，井上高光，土谷順彦，佐藤滋，羽渕友則
  • Organizer: 第73回日本癌学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 高脂肪食下前立腺がん進展におけるFASNの役割 (2014)
  • Author(s): 黄明国、成田伸太郎，井上高光，土谷順彦，佐藤滋，羽渕友則
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression (2013)
  • Author(s): Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
• [Presentation] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression (2013)
  • Author(s): Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 長鎖脂肪酸パルミチンによる前立腺癌進展の機序解明 (2012)
  • Author(s): 黄明国、
  • Organizer: 第100回日本泌尿器科学会
  • Place of Presentation: 横浜
• [Presentation] 長鎖脂肪酸パルミチンによる前立腺癌進展の機序解明 (2012)
  • Author(s): 黄明国、
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌