| Project/Area Number |
24592381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONAKA Hiroyuki 金沢大学, 大学病院, 講師 (40334768)
KYO Satoru 島根大学, 医学部, 教授 (50272969)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 泌尿器癌 / テロメラーゼ / 血管内浮遊癌細胞 / テロメアーゼ |
|---|
| Outline of Final Research Achievements |
Novel adenovirus vector with human telomerase reverse transcriptase (hTERT) promoter could be constructed. In vitro, renal cancer cells (ACHN) and prostate cancer cells (PC3, LNCaP, DU145) were detected in human blood using this vector, however, 100 to 1000 cells were needed to detect in 1 ml of human blood, which was insufficient for the clinical practice. In vivo, circulating tumor cells could not be detected in the human blood samples of 30 patients with urological cancers (10 renal cell carcinoma, 12 urothelial carcinoma, 8 prostate cancer).
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