Investigation of molecular mechanism of FGF family involved in prostate cancer and metabolic syndrome

• Project/Area Number: 24592392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Hiroshima University
• Principal Investigator: TEISHIMA Jun 広島大学, 大学院医歯薬保健学研究院, 講師 (20397962)
• Co-Investigator(Kenkyū-buntansha): MATSUBARA Akio 広島大学, 大学院医歯薬保健学研究院, 教授 (10239064) ; INOUE Shogo 広島大学, 病院, 助教 (90457177) ; SHOJI Koichi 広島大学, 病院, 助教 (90565805)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed(Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost : ¥4,100,000、Indirect Cost : ¥1,230,000); Fiscal Year 2014 : ¥1,430,000 (Direct Cost : ¥1,100,000、Indirect Cost : ¥330,000); Fiscal Year 2013 : ¥1,950,000 (Direct Cost : ¥1,500,000、Indirect Cost : ¥450,000); Fiscal Year 2012 : ¥1,950,000 (Direct Cost : ¥1,500,000、Indirect Cost : ¥450,000)
• Keywords: 前立腺癌 / 増殖因子 / 上皮間葉移行 / メタボリック症候群 / 癌 / FGF19

Outline of Final Research Achievements

Serum FGF19/21 levels in high Gleason grade group was significantly higher than that in low Gleason grade group. In the immunostaining, the biochemical recurrence free survival rate in FGF19/21-positive group was lower than that in FGF21-negative group. Cell viability and the expression of EMT marker were significantly enhanced by treatment with FGF19/21 in LNCaP and PC3 cells. Our data indicate that FGF21 might be associated with biochemical recurrence by promoting cell proliferation of prostate cancer.

Research Products

• [Journal Article] FGF19 promotes progression of prostate cancer. (2015)
  • Author(s): Nagamatsu H, Teishima J, Goto K, Shikuma H, Kitano H, Shoji K, Inoue S, Matsubara A.
  • Journal Title: The Prostate Volume : Apr 8 Pages : 1092-101
  • DOI: 10.1002/pros.22994
  • Peer Reviewed / Open Access
• [Journal Article] Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. (2014)
  • Author(s): Shoji K, Teishima J, Hayashi T, Ohara S, Mckeehan WL, Matsubara A.
  • Journal Title: Oncology Reports Volume : Jul;32(1) Pages : 65-70
  • DOI: 10.3892/or.2014.3200
  • Peer Reviewed / Open Access
• [Journal Article] Accumulation of FGF9 in prostate cancer correlates with epithelial-to-mesenchymal transition and induction of VEGF-A expression. (2014)
  • Author(s): Teishima J, Yano S, Shoji K, Hayashi T, Goto K, Kitano H, Oka K, Nagamatsu H, Matsubara A.
  • Journal Title: Anticancer Research Volume : Feb;34(2) Pages : 695-700
  • Peer Reviewed / Open Access
• [Journal Article] Expression of novel biomarkers identified by Escherichia coli ampicillin secretion trap: Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer (2014)
  • Author(s): Goto K, Oue N, Hayashi T, Shinmei S, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
  • Journal Title: Pathobiology Volume : 81 Pages : 190-198
  • DOI: 10.1159/000363345
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method (2014)
  • Author(s): Shunsuke Shinmei, Kazuhiro Sentani, Tetsutaro Hayashi, Naoya Sakamoto, Keisuke Goto, Htoo Zarni Oo, Yutaka Naito, Jun Teishima, Akio Matsubara, Naohide Oue, Hiroki Kuniyasu, Wataru Yasui
  • Journal Title: Urologic Oncology Volume : 32 Pages : 769-778
  • DOI: 10.1016/j.urolonc.2014.03.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prostate cancer detection by prostate-specific antigen-based screening in the Japanese Hiroshima area shows early stage, low-grade, and low rate of cancer-specific death compared with clinical detection. (2014)
  • Author(s): Teishima J, Maruyama S, Mochizuki H, Oka K, Ikeda K, Goto K, Nagamatsu H, Hieda K, Shoji K, Matsubara A.
  • Journal Title: Canadian Urology Assocciation Journal Volume : May;8(5-6)
  • Peer Reviewed
• [Journal Article] Accumulation of FGF9 in Prostate Cancer Correlates with Epithelial-to-Mesenchymal Transition and Induction of VEGF-A Expression. (2014)
  • Author(s): Teishima J, Yano S, Shoji K, Hayashi T, Goto K, Kitano H, Oka K, Nagamatsu H, Matsubara A.
  • Journal Title: Anticancer Res Volume : 34(2) Pages : 695-700
  • Peer Reviewed
• [Journal Article] Development of Nomogram to Non-steroidal Antiandrogen Sequential Alternation in Prostate Cancer for Predictive Model. (2014)
  • Author(s): Kamiya N, Suzuki H, Nishimura K, Fujii M, Okegawa T, Matsuda T, Morita T, Takihana Y, Ozono S, Namiki M, Matsubara A, Ichikawa T, Miki T.
  • Journal Title: Jpn J Clin Oncol Volume : 44(3) Pages : 263-269
  • Peer Reviewed
• [Journal Article] Restoration of IGFBP-rP1 increases radiosensitivity and chemosensitivity in hormone-refractory human prostate cancer. (2013)
  • Author(s): Seki M, Teishima J, Mochizuki H, Mutaguchi K, Yasumoto H, Oka K, Nagamatsu H, Shoji K, Matsubara A
  • Journal Title: Hiroshima J Med Sci Volume : 62(1) Pages : 13-19
  • Peer Reviewed
• [Journal Article] The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression. (2013)
  • Author(s): Hayashi T, Sentani K, Oue N, Ohara S, Teishima J, Anami K, Sakamoto N, Matsubara A, Yasui W.
  • Journal Title: Pathobiology Volume : 80 Pages : 60-69
  • DOI: 10.1159/000341396
  • Peer Reviewed
• [Journal Article] Expression of miR-486 is a potential prognostic factor after neophrectomy in advanced renal cell carcinoma (2013)
  • Author(s): Keisuke Goto, Naohide Oue, Shunsuke Shinmei, Kazuhiro Sentani, Naoya Sakamoto, Yutaka Naito, Tetsutaro Hauashi, Jun Teishima, Akio Matsubara, Wataru Yasui
  • Journal Title: Molecular and Clinical Oncology Volume : 1 Pages : 235-240
  • DOI: 10.3892/mco.2012.46
  • Peer Reviewed
• [Journal Article] Relationship between the localization of fibroblast growth factor 9 in prostate cancer cells and postoperative recurrence. (2012)
  • Author(s): Teishima J, Shoji K, Hayashi T, Miyamoto K, Ohara S, Matsubara A.
  • Journal Title: Prostate Cancer Prostatic Dis. Volume : 15 Pages : 8-14
  • DOI: 10.1038/pcan.2011.48
  • Peer Reviewed
• [Journal Article] Impact of pre-implant lower urinary tract symptoms on postoperative urinary morbidity after permanent prostate brachytherapy. (2012)
  • Author(s): Teishima J, Iwamoto H, Miyamoto K, Shoji K, Masumoto H, Inoue S, Kobayashi K, Kajiwara M, Matsubara A.
  • Journal Title: Int J Urol. Volume : 19(12) Pages : 1083-1089
  • DOI: 10.1111/j.1442-2042.2012.03105.x
  • Peer Reviewed
• [Journal Article] Impact of laparoscopic experience on the proficiency gain of urologic surgeons in robot-assisted surgery. (2012)
  • Author(s): Teishima J, Hattori M, Inoue S, Ikeda K, Hieda K, Miyamoto K, Shoji K, Hayashi T, Kobayashi K, Kajiwara M, Egi H, Ohdan H, Matsubara A..
  • Journal Title: J Endourol. Volume : 26(12) Pages : 1635-1638
  • DOI: 10.1089/end.2012.0308
  • Peer Reviewed
• [Presentation] 去勢抵抗性前立腺癌におけるregIVの意義 (2014)
  • Author(s): 亭島 淳、正路晃一、 山中亮憲、 後藤景介、 永松弘孝、 大原慎也、 林 哲太郎、 岡清貴、 大上直秀、 安井 弥、 松原昭郎
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25
• [Presentation] Endocrine FGFs promote progression in prostate cancer (2014)
  • Author(s): 永松弘孝、亭島 淳、後藤景介、松原昭郎
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25
• [Presentation] Regenerating islet-derived family, member 4 enhances cell proliferation, castration-resistance, and chemoresistance through acceleration of neuroendocrine differentiation in human prostate cancer cells. (2014)
  • Author(s): Jun Teishima, Koichi Shoji, Keisuke Goto, Ryoken Yamaoka, Hiroyuki Shikuma, Hirotaka Nagamatsu, Kiyotaka Oka, Shunsuke Shinmei, Hiroyuki Kitano, Shinya Ohara, Tetsutaro Hayashi, Norihide Oue, Wataru Yasui, Akio Matsubara
  • Organizer: AUA Annual Meeting 2014
  • Place of Presentation: Orlando
  • Year and Date: 2014-05-19
• [Presentation] Restoration of Fibroblast Growth Factor Receptor 2IIIb Enhances the Chemosensitivity of Human Prostate Cancer Cells. (2014)
  • Author(s): Koichi Shoji, Jun Teishima, Shinya Ohara, Akio Matsubara
  • Organizer: AUA Annual Meeting 2014
  • Place of Presentation: Orlando
  • Year and Date: 2014-05-18
• [Presentation] FGF19 subfamily promotes progression in prostate cancer cells. (2014)
  • Author(s): Hirotaka Nagamatsu, Jun Teishima, Keisuke Goto, Akio Matsubara.
  • Organizer: AUA Annual Meeting 2014
  • Place of Presentation: Orlando
  • Year and Date: 2014-05-18
• [Presentation] FGF19は前立線癌細胞の増殖を促進する (2014)
  • Author(s): 永松弘孝、亭島 淳、後藤景介、正路晃一、松原昭郎
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-25
• [Presentation] 前立腺癌細胞におけるFGFR2Ⅲbの発現回復は化学療法感受性を増強する (2014)
  • Author(s): 正路晃一、亭島 淳、大原慎也、松原昭郎
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-25
• [Presentation] 前立線癌におけるReg Ⅳの意義 (2014)
  • Author(s): 亭島 淳、永松弘孝、北野弘之、後藤景介、岡 清貴、正路晃一、大上直秀、安井 弥、松原昭郎
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-25
• [Presentation] Regenetrating islet-derived family, member 4 enhances cell proliferation, castration-resistance and chemoresistance through aceleration of neuroendocrine differentiation in human prostate cancer cells. (2014)
  • Author(s): J.Teishima, K.Shoji, K.Goto, R.Yamanaka, H.Shikuma, H.Nagamatsu, S.Shinmei, H.Kitano, S.Ohara, T.hayashi, N.Oue, W.Yasui, A.Matsubara.
  • Organizer: 29th Annual EAU Congress
  • Place of Presentation: Stockholm
  • Year and Date: 2014-04-12
• [Presentation] Fibroblast growth factor 9 in prostate cancer cells is associated with postoperative recurrence through acceleration of mesenchymal transition, proliferation and invasion. (2013)
  • Author(s): Jun Teishima, Koichi Shoji, Tetsutaro Hayashi, Shigeki Yano, Kiyotaka Oka, Hirotaka Nagamatsu, Shinya Ohara, and Akio Matsubara
  • Organizer: 108th Annual Meeting of the American Urological Association
  • Place of Presentation: San Diego, USA
• [Presentation] Accumulation of Fibroblast growth factor 9 in prostate cancer cells correlate with mesenchymal transition and the induction of VEGFA expression. (2013)
  • Author(s): Jun Teishima, Shigeki Yano, Tetsutaro Hayashi, Koichi Shoji, Kiyotaka Oka, Hirotaka Nagamatsu, Shinya Ohara, and Akio Matsubara
  • Organizer: 33rd Congress of the SIU
  • Place of Presentation: Vancouver, Canada
• [Presentation] 前立腺癌細胞の増殖と浸潤におけるFGF9の役割 (2012)
  • Author(s): 亭島淳、林哲太郎、正路晃一、大原慎也、松原昭郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜市
• [Presentation] The Effects of Fibroblast Growth Factor 9 in Prostate Cancer Cells. (2012)
  • Author(s): Teishima J, Shoji K, Hayashi T, Oka K, Nagamatsu H, Ohara S, Matsubara A.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市
• [Presentation] A Role of FGFR2IIIb in the Chemosensitivity of Castration-resistant Prostate Cancer Cells. (2012)
  • Author(s): Shoji K, Teishima J, Ohara S, Hayashi T, Matsubara A.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市
• [Presentation] 前立腺癌の化学療法感受性におけるFGFR2の役割 (2012)
  • Author(s): 正路晃一、亭島 淳、林哲太郎、柴田昌紀、池田健一郎、稗田圭介、宮本克利、増本弘史、井上省吾、小林加直、梶原充、松原昭郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] Fibroblast Growth Factor 9 in Prostate Cancer Cells is Associated With Postoperative Recurrence Through Accelearation of Mesenchymal Transition, Proliferation, and Invasion.
  • Author(s): Jun Teishima
  • Organizer: AUA 2013 Annual Meeting
  • Place of Presentation: San Diego, (USA)
• [Presentation] 前立線癌治療におけるホルモン療法についてのご意見・アドバイス
  • Author(s): 亭島 淳
  • Organizer: アドバイザリーミーティング
  • Place of Presentation: 広島市
  • Invited
• [Presentation] 前立腺がん治療の最前線
  • Author(s): 亭島 淳
  • Organizer: 広島がんサポート講演会
  • Place of Presentation: 広島市
  • Invited
• [Presentation] 前立腺癌細胞におけるFGF9の集積は上皮間葉移行およびVEGFAの誘導に関与する
  • Author(s): 亭島 淳
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜市
• [Presentation] 去勢抵抗性前立腺癌の診療実態についての意見・アドバイス
  • Author(s): 亭島 淳
  • Organizer: アドバイザリーミーティング
  • Place of Presentation: 広島市
  • Invited
• [Presentation] 前立線癌の進行におけるRegIVの役割
  • Author(s): 亭島 淳、正路晃一、永松弘孝、 後藤景介、北野弘之、岡清貴、 大上直秀、安井弥、松原昭郎
  • Organizer: 第23回泌尿器科分子・細胞研究会
  • Place of Presentation: 山形市
• [Presentation] 前立線癌についての最近の知見
  • Author(s): 亭島 淳
  • Organizer: アステラスレクチャーミーティング
  • Place of Presentation: 広島市
  • Invited
• [Presentation] The role of regenerating islet-derived family, member 4 in human castration-resistant prostate cancer cells.
  • Author(s): Jun Teishima
  • Organizer: The 4th Congress of Asian Pacific Prostate Society (APPS2014)
  • Place of Presentation: 名護市