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Investigation of molecular mechanism of FGF family involved in prostate cancer and metabolic syndrome

Research Project

Project/Area Number 24592392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionHiroshima University

Principal Investigator

TEISHIMA Jun  広島大学, 大学院医歯薬保健学研究院, 講師 (20397962)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Akio  広島大学, 大学院医歯薬保健学研究院, 教授 (10239064)
INOUE Shogo  広島大学, 病院, 助教 (90457177)
SHOJI Koichi  広島大学, 病院, 助教 (90565805)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords前立腺癌 / 増殖因子 / 上皮間葉移行 / メタボリック症候群 / 癌 / FGF19
Outline of Final Research Achievements

Serum FGF19/21 levels in high Gleason grade group was significantly higher than that in low Gleason grade group. In the immunostaining, the biochemical recurrence free survival rate in FGF19/21-positive group was lower than that in FGF21-negative group. Cell viability and the expression of EMT marker were significantly enhanced by treatment with FGF19/21 in LNCaP and PC3 cells. Our data indicate that FGF21 might be associated with biochemical recurrence by promoting cell proliferation of prostate cancer.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (37 results)

All 2015 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Invited: 4 results)

  • [Journal Article] FGF19 promotes progression of prostate cancer.2015

    • Author(s)
      Nagamatsu H, Teishima J, Goto K, Shikuma H, Kitano H, Shoji K, Inoue S, Matsubara A.
    • Journal Title

      The Prostate

      Volume: Apr 8 Issue: 10 Pages: 1092-101

    • DOI

      10.1002/pros.22994

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells.2014

    • Author(s)
      Shoji K, Teishima J, Hayashi T, Ohara S, Mckeehan WL, Matsubara A.
    • Journal Title

      Oncology Reports

      Volume: Jul;32(1) Issue: 1 Pages: 65-70

    • DOI

      10.3892/or.2014.3200

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accumulation of FGF9 in prostate cancer correlates with epithelial-to-mesenchymal transition and induction of VEGF-A expression.2014

    • Author(s)
      Teishima J, Yano S, Shoji K, Hayashi T, Goto K, Kitano H, Oka K, Nagamatsu H, Matsubara A.
    • Journal Title

      Anticancer Research

      Volume: Feb;34(2) Pages: 695-700

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of novel biomarkers identified by Escherichia coli ampicillin secretion trap: Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer2014

    • Author(s)
      Goto K, Oue N, Hayashi T, Shinmei S, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
    • Journal Title

      Pathobiology

      Volume: 81 Issue: 4 Pages: 190-198

    • DOI

      10.1159/000363345

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method2014

    • Author(s)
      Shunsuke Shinmei, Kazuhiro Sentani, Tetsutaro Hayashi, Naoya Sakamoto, Keisuke Goto, Htoo Zarni Oo, Yutaka Naito, Jun Teishima, Akio Matsubara, Naohide Oue, Hiroki Kuniyasu, Wataru Yasui
    • Journal Title

      Urologic Oncology

      Volume: 32 Issue: 6 Pages: 769-778

    • DOI

      10.1016/j.urolonc.2014.03.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostate cancer detection by prostate-specific antigen-based screening in the Japanese Hiroshima area shows early stage, low-grade, and low rate of cancer-specific death compared with clinical detection.2014

    • Author(s)
      Teishima J, Maruyama S, Mochizuki H, Oka K, Ikeda K, Goto K, Nagamatsu H, Hieda K, Shoji K, Matsubara A.
    • Journal Title

      Canadian Urology Assocciation Journal

      Volume: May;8(5-6)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of FGF9 in Prostate Cancer Correlates with Epithelial-to-Mesenchymal Transition and Induction of VEGF-A Expression.2014

    • Author(s)
      Teishima J, Yano S, Shoji K, Hayashi T, Goto K, Kitano H, Oka K, Nagamatsu H, Matsubara A.
    • Journal Title

      Anticancer Res

      Volume: 34(2) Pages: 695-700

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Nomogram to Non-steroidal Antiandrogen Sequential Alternation in Prostate Cancer for Predictive Model.2014

    • Author(s)
      Kamiya N, Suzuki H, Nishimura K, Fujii M, Okegawa T, Matsuda T, Morita T, Takihana Y, Ozono S, Namiki M, Matsubara A, Ichikawa T, Miki T.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44(3) Pages: 263-269

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Restoration of IGFBP-rP1 increases radiosensitivity and chemosensitivity in hormone-refractory human prostate cancer.2013

    • Author(s)
      Seki M, Teishima J, Mochizuki H, Mutaguchi K, Yasumoto H, Oka K, Nagamatsu H, Shoji K, Matsubara A
    • Journal Title

      Hiroshima J Med Sci

      Volume: 62(1) Pages: 13-19

    • NAID

      120005323993

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression.2013

    • Author(s)
      Hayashi T, Sentani K, Oue N, Ohara S, Teishima J, Anami K, Sakamoto N, Matsubara A, Yasui W.
    • Journal Title

      Pathobiology

      Volume: 80 Issue: 2 Pages: 60-69

    • DOI

      10.1159/000341396

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of miR-486 is a potential prognostic factor after neophrectomy in advanced renal cell carcinoma2013

    • Author(s)
      Keisuke Goto, Naohide Oue, Shunsuke Shinmei, Kazuhiro Sentani, Naoya Sakamoto, Yutaka Naito, Tetsutaro Hauashi, Jun Teishima, Akio Matsubara, Wataru Yasui
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 1 Issue: 2 Pages: 235-240

    • DOI

      10.3892/mco.2012.46

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between the localization of fibroblast growth factor 9 in prostate cancer cells and postoperative recurrence.2012

    • Author(s)
      Teishima J, Shoji K, Hayashi T, Miyamoto K, Ohara S, Matsubara A.
    • Journal Title

      Prostate Cancer Prostatic Dis.

      Volume: 15 Issue: 1 Pages: 8-14

    • DOI

      10.1038/pcan.2011.48

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of pre-implant lower urinary tract symptoms on postoperative urinary morbidity after permanent prostate brachytherapy.2012

    • Author(s)
      Teishima J, Iwamoto H, Miyamoto K, Shoji K, Masumoto H, Inoue S, Kobayashi K, Kajiwara M, Matsubara A.
    • Journal Title

      Int J Urol.

      Volume: 19(12) Issue: 12 Pages: 1083-1089

    • DOI

      10.1111/j.1442-2042.2012.03105.x

    • NAID

      10031136952

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of laparoscopic experience on the proficiency gain of urologic surgeons in robot-assisted surgery.2012

    • Author(s)
      Teishima J, Hattori M, Inoue S, Ikeda K, Hieda K, Miyamoto K, Shoji K, Hayashi T, Kobayashi K, Kajiwara M, Egi H, Ohdan H, Matsubara A..
    • Journal Title

      J Endourol.

      Volume: 26(12) Issue: 12 Pages: 1635-1638

    • DOI

      10.1089/end.2012.0308

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 去勢抵抗性前立腺癌におけるregIVの意義2014

    • Author(s)
      亭島 淳、正路晃一、 山中亮憲、 後藤景介、 永松弘孝、 大原慎也、 林 哲太郎、 岡清貴、 大上直秀、 安井 弥、 松原昭郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Endocrine FGFs promote progression in prostate cancer2014

    • Author(s)
      永松弘孝、亭島 淳、後藤景介、松原昭郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regenerating islet-derived family, member 4 enhances cell proliferation, castration-resistance, and chemoresistance through acceleration of neuroendocrine differentiation in human prostate cancer cells.2014

    • Author(s)
      Jun Teishima, Koichi Shoji, Keisuke Goto, Ryoken Yamaoka, Hiroyuki Shikuma, Hirotaka Nagamatsu, Kiyotaka Oka, Shunsuke Shinmei, Hiroyuki Kitano, Shinya Ohara, Tetsutaro Hayashi, Norihide Oue, Wataru Yasui, Akio Matsubara
    • Organizer
      AUA Annual Meeting 2014
    • Place of Presentation
      Orlando
    • Year and Date
      2014-05-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Restoration of Fibroblast Growth Factor Receptor 2IIIb Enhances the Chemosensitivity of Human Prostate Cancer Cells.2014

    • Author(s)
      Koichi Shoji, Jun Teishima, Shinya Ohara, Akio Matsubara
    • Organizer
      AUA Annual Meeting 2014
    • Place of Presentation
      Orlando
    • Year and Date
      2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] FGF19 subfamily promotes progression in prostate cancer cells.2014

    • Author(s)
      Hirotaka Nagamatsu, Jun Teishima, Keisuke Goto, Akio Matsubara.
    • Organizer
      AUA Annual Meeting 2014
    • Place of Presentation
      Orlando
    • Year and Date
      2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] FGF19は前立線癌細胞の増殖を促進する2014

    • Author(s)
      永松弘孝、亭島 淳、後藤景介、正路晃一、松原昭郎
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 前立腺癌細胞におけるFGFR2Ⅲbの発現回復は化学療法感受性を増強する2014

    • Author(s)
      正路晃一、亭島 淳、大原慎也、松原昭郎
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 前立線癌におけるReg Ⅳの意義2014

    • Author(s)
      亭島 淳、永松弘孝、北野弘之、後藤景介、岡 清貴、正路晃一、大上直秀、安井 弥、松原昭郎
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regenetrating islet-derived family, member 4 enhances cell proliferation, castration-resistance and chemoresistance through aceleration of neuroendocrine differentiation in human prostate cancer cells.2014

    • Author(s)
      J.Teishima, K.Shoji, K.Goto, R.Yamanaka, H.Shikuma, H.Nagamatsu, S.Shinmei, H.Kitano, S.Ohara, T.hayashi, N.Oue, W.Yasui, A.Matsubara.
    • Organizer
      29th Annual EAU Congress
    • Place of Presentation
      Stockholm
    • Year and Date
      2014-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fibroblast growth factor 9 in prostate cancer cells is associated with postoperative recurrence through acceleration of mesenchymal transition, proliferation and invasion.2013

    • Author(s)
      Jun Teishima, Koichi Shoji, Tetsutaro Hayashi, Shigeki Yano, Kiyotaka Oka, Hirotaka Nagamatsu, Shinya Ohara, and Akio Matsubara
    • Organizer
      108th Annual Meeting of the American Urological Association
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Accumulation of Fibroblast growth factor 9 in prostate cancer cells correlate with mesenchymal transition and the induction of VEGFA expression.2013

    • Author(s)
      Jun Teishima, Shigeki Yano, Tetsutaro Hayashi, Koichi Shoji, Kiyotaka Oka, Hirotaka Nagamatsu, Shinya Ohara, and Akio Matsubara
    • Organizer
      33rd Congress of the SIU
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 前立腺癌細胞の増殖と浸潤におけるFGF9の役割2012

    • Author(s)
      亭島淳、林哲太郎、正路晃一、大原慎也、松原昭郎
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] The Effects of Fibroblast Growth Factor 9 in Prostate Cancer Cells.2012

    • Author(s)
      Teishima J, Shoji K, Hayashi T, Oka K, Nagamatsu H, Ohara S, Matsubara A.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] A Role of FGFR2IIIb in the Chemosensitivity of Castration-resistant Prostate Cancer Cells.2012

    • Author(s)
      Shoji K, Teishima J, Ohara S, Hayashi T, Matsubara A.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] 前立腺癌の化学療法感受性におけるFGFR2の役割2012

    • Author(s)
      正路晃一、亭島 淳、林哲太郎、柴田昌紀、池田健一郎、稗田圭介、宮本克利、増本弘史、井上省吾、小林加直、梶原充、松原昭郎
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Fibroblast Growth Factor 9 in Prostate Cancer Cells is Associated With Postoperative Recurrence Through Accelearation of Mesenchymal Transition, Proliferation, and Invasion.

    • Author(s)
      Jun Teishima
    • Organizer
      AUA 2013 Annual Meeting
    • Place of Presentation
      San Diego, (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 前立線癌治療におけるホルモン療法についてのご意見・アドバイス

    • Author(s)
      亭島 淳
    • Organizer
      アドバイザリーミーティング
    • Place of Presentation
      広島市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 前立腺がん治療の最前線

    • Author(s)
      亭島 淳
    • Organizer
      広島がんサポート講演会
    • Place of Presentation
      広島市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 前立腺癌細胞におけるFGF9の集積は上皮間葉移行およびVEGFAの誘導に関与する

    • Author(s)
      亭島 淳
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Research-status Report
  • [Presentation] 去勢抵抗性前立腺癌の診療実態についての意見・アドバイス

    • Author(s)
      亭島 淳
    • Organizer
      アドバイザリーミーティング
    • Place of Presentation
      広島市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 前立線癌の進行におけるRegIVの役割

    • Author(s)
      亭島 淳、正路晃一、永松弘孝、 後藤景介、北野弘之、岡清貴、 大上直秀、安井弥、松原昭郎
    • Organizer
      第23回泌尿器科分子・細胞研究会
    • Place of Presentation
      山形市
    • Related Report
      2013 Research-status Report
  • [Presentation] 前立線癌についての最近の知見

    • Author(s)
      亭島 淳
    • Organizer
      アステラスレクチャーミーティング
    • Place of Presentation
      広島市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The role of regenerating islet-derived family, member 4 in human castration-resistant prostate cancer cells.

    • Author(s)
      Jun Teishima
    • Organizer
      The 4th Congress of Asian Pacific Prostate Society (APPS2014)
    • Place of Presentation
      名護市
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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