| Project/Area Number |
24592398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORISHITA Kazuhiro 宮崎大学, 医学部機能制御学講座腫瘍生化学分野, 教授 (80260321)
MUKAI Shoichiro 宮崎大学, 医学部外科学講座 泌尿器科学分野, 講師 (10315369)
SUGIE Satoru 宮崎大学, 医学部外科学講座泌尿器科学分野, 医員 (50626140)
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| Research Collaborator |
TSUKINO Hiromasa 宮崎大学, 医学部外科学講座泌尿器科学分野, 講師 (60433059)
KAMIBEPPU Toyoharu 宮崎大学, 医学部外科学講座泌尿器科学分野, 医員 (90649641)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 前立腺 / シグナル伝達 / 前立腺癌 / caveolin / 癌 / タンパク質 / 蛋白質 |
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| Outline of Final Research Achievements |
We evaluated associations between plasma CAV1 levels and prostate cancer in Japanese men, and CAV1 expression in PC3 and LNCaP cell lines. As a results, plasma CAV1 levels in patients with CRPC were much higher than in those with non-CRPC(p<0.004). In vitro analyses showed CAV1 protein and mRNA in PC3 cells to be significantly overexpressed compared to that in LNCaP cells (p<0.0001).In conclusion, our results support the possibility of CAV1 as a therapeutic target for CRPC. And then, we evaluated the relationship between the CAV1 T29107A polymorphism and the risk of prostate cancer among Japanese populations. As a results, logistic regression analysis of case and control outcomes showed an odds ratio of 0.35 (p=0.033) between the TT and AA polymorphisms, indicating a reduced risk of prostate cancer to be associated with the AA polymorphism. Our results support the hypothesis that this polymorphism may influence susceptibility to prostate cancer.
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