| Project/Area Number |
24592402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASHIMOTO yoshihiro 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (40244561)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Noriyasu 名古屋市立大学, 大学院医学研究科, 講師 (20254279)
KOHRI Kenjiro 名古屋市立大学, 大学院医学研究科, 教授 (30122047)
NAKANISHI Makoto 名古屋市立大学, 大学院医学研究科, 教授 (40217774)
HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134)
TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | SRC-3 / PI3K/AKT/mTOR / 分子標的治療 / PI3K/AKT/mTOR経路 |
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| Outline of Final Research Achievements |
As our analysis result, cyclin D2, E2, M4, T2 and CDC25A for cell cycle regulator and IGF-I, IGF-II, IRS-1, IRS-2, PIK3CA and AKT1 for AKT signal system and BIRC2, BIRC3 and GADD45B for NFkB signal system were recognized as genes controlled by nuclear receptor transcription conjugate factor SRC-3.
As for cyclin E and CDC25A of cell cycle regulator, not only the binding capacity but also the promoter transcription activity was recognized for androgen receptor, SRC-3 and PI3K/AKT/mTOR-related factor, and can expect participation in hormone-resistant mechanism acquisition of the prostate cancer and application to molecules target treatment.
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