Analysis of the nuclear receptor transcription conjugate mechanism for the hormone-resistant prostate cancer and development of the new molecular target treatment

• Project/Area Number: 24592402
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: HASHIMOTO yoshihiro 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (40244561)
• Co-Investigator(Kenkyū-buntansha): KAWAI Noriyasu 名古屋市立大学, 大学院医学研究科, 講師 (20254279) ; KOHRI Kenjiro 名古屋市立大学, 大学院医学研究科, 教授 (30122047) ; NAKANISHI Makoto 名古屋市立大学, 大学院医学研究科, 教授 (40217774) ; HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134) ; TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: SRC-3 / PI3K/AKT/mTOR / 分子標的治療 / PI3K/AKT/mTOR経路

Outline of Final Research Achievements

As our analysis result, cyclin D2, E2, M4, T2 and CDC25A for cell cycle regulator and IGF-I, IGF-II, IRS-1, IRS-2, PIK3CA and AKT1 for AKT signal system and BIRC2, BIRC3 and GADD45B for NFkB signal system were recognized as genes controlled by nuclear receptor transcription conjugate factor SRC-3.
As for cyclin E and CDC25A of cell cycle regulator, not only the binding capacity but also the promoter transcription activity was recognized for androgen receptor, SRC-3 and PI3K/AKT/mTOR-related factor, and can expect participation in hormone-resistant mechanism acquisition of the prostate cancer and application to molecules target treatment.

Research Products

• [Journal Article] Efficacy of endoscopic combined intrarenal surgery in the prone split-leg position for staghorn calculi (2015)
  • Author(s): Hamamoto S, Yasui T, Taguchi K, Itoh Y, Kawai N, Hashimoto Y, Kohri K
  • Journal Title: J Endourol. Volume: 1 Pages: 19-24
  • Peer Reviewed / Open Access
• [Journal Article] Gemcitabine and docetaxel, an effective second-line chemotherapy for lung metastasis of urothelial carcinoma (2014)
  • Author(s): Naiki T, Kawai N, Hashimoto Y, Okamura T, Ando R, Yasui T, Okada A, Etani T, Tozawa K, Kohri K.
  • Journal Title: Int J Clin Oncol. Volume: 3 Pages: 516-522
  • Peer Reviewed / Open Access
• [Journal Article] Combined endoscopic surgery in the prone-split leg position for successful single-session removal of an encrusted ureteral stent (2014)
  • Author(s): Isero T, Hamamoto S, Koiwa S, Kamiya H, Hashimoto Y, Yasui T, Iwase Y, Kohri K.
  • Journal Title: J Med Case Rep Volume: 8 Pages: 128-128
  • Peer Reviewed / Open Access
• [Journal Article] Laparoendoscopic Single-Site Partial Nephrectomy Without Hilar Clamping Using a Microwave Tissue Coagulator. (2014)
  • Author(s): Kawai Noriyasu, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: Journal of Endourology Volume: 28(2) Issue: 2 Pages: 184-190
  • DOI: 10.1089/end.2013.0135
  • Peer Reviewed
• [Journal Article] Are there time-period-related differences in the prophylactic effects of bacille calmette-guérin intravesical instillation therapy in Japan? (2012)
  • Author(s): Okamura Takehiko, Ando Ryosuke, Akita Hidetoshi, Hashimoto Yoshihiro
  • Journal Title: Asian Pacific Journal of Cancer Prevention Volume: 13 Pages: 4357-4361
  • Peer Reviewed
• [Journal Article] Successful treatment of primary malignant lymphoma of the penis by organ-preserving rituximab-containing chemotherapy (2012)
  • Author(s): Hamamoto Shuzo, Tozawa Keiichi, Nishio Hidenori, Kawai Noriyasu
  • Journal Title: Int J Clin Oncol Volume: 17 Issue: 2 Pages: 181-184
  • DOI: 10.1007/s10147-011-0273-8
  • NAID: 10030626659
  • Peer Reviewed
• [Presentation] 当院における進行性腎細胞癌に対するEverolimusの治療成績 (2015)
  • Author(s): 橋本 良博、奥田 奈央子、小岩 哲、濱本 周造、神谷 浩行、岩瀬 豊
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2015-04-18 – 2015-04-21
• [Presentation] Treatment effects of recombinant human thrombomodulin in patients with septic urinary tract infection induced disseminated intravascular coagulation (2014)
  • Author(s): Yoshihiro Hashimoto, Naoko Okuda, Satoshi Koiwa, Shuzo Hamamoto, Hiroyuki Kamiya, Yutaka Iwase
  • Organizer: 34th Congress of the Societe Internationale d'Urologie
  • Place of Presentation: Glasgow（スコットランド）
  • Year and Date: 2014-10-12 – 2014-10-15
• [Presentation] Treatment effects of thrombomodulin in patients with septic urinary tract infection-induced disseminated intravascular coagulation (2014)
  • Author(s): HashimotoY., Tozawa K., Kohri K.
  • Organizer: 16th International Congress of Infectious Diseases
  • Place of Presentation: ケープタウン国際コンベンションセンター （ケープタウン、南アフリカ）
• [Presentation] 前立腺癌の増殖におけるsteroid Receptor Co-activatorを介したPl3K/AKT/mTOR経路の関与 (2014)
  • Author(s): 橋本 良博、河合 憲康、戸澤 啓一、郡 健二郎
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 進行性尿路上皮癌に対するGC療法による術前補助化学療法の検討 (2013)
  • Author(s): 橋本 良博、小岩 哲、伊勢呂 哲也、濱本 周造、神谷 浩行、岩瀬 豊
  • Organizer: 第65回西日本泌尿器科学会総会
  • Place of Presentation: マリトピア・アバンセ（佐賀市）
• [Presentation] Treatment effects of recombinant human soluble thrombomodulin in patients with septic urinary tract infection-induced disseminated intravascular coagulation (2013)
  • Author(s): Yoshihiro Hashimoto; Noriyasu Kawai; Keiichi Tozawa; Kenjiro Kohri
  • Organizer: American Urological Association Annual Meeting 2013
  • Place of Presentation: San Diego Convention Center( San Diego, USA)
• [Presentation] Successful results of endoscopic combined intrarenal surgery against large calculi; simultaneous use of flexible ureteroscopy and mini-percutaneous nephrolithotomy overcame the drawbacks of the monotherapy of percutaneous nephrolithotomy (2013)
  • Author(s): Shuzo Hamamoto; Yoshihiro Hashimoto; Keiichi Tozawa; Kenjiro Kohri
  • Organizer: American Urological Association Annual Meeting 2013
  • Place of Presentation: San Diego Convention Center( San Diego, USA)
• [Presentation] Overexpression of Cdc25C, an Androgen Receptor Coactivator, in Human Prostate Cancer (2013)
  • Author(s): Yoshihiro Hashimoto, Satoshi Koiwa, Tetsuya Isero, Shuzo Hamamoto, Hiroyuki Kamiya, Yutaka Iwase
  • Organizer: 24th International Congress on Anti-Cancer Treatment
  • Place of Presentation: Paris(France)
• [Presentation] ホルモン抵抗性前立腺癌に対するステロイド併用ドセタキセル療法の検討 (2012)
  • Author(s): 橋本 良博、伊勢呂 哲也、惠谷 俊紀、神谷 浩行、岩瀬 豊
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)