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Development of a new therapy for prostate cancer by the fusion of the thermotherapy mediated by magnetic field and the immunotherapy

Research Project

Project/Area Number 24592403
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

KAWAI Noriyasu  名古屋市立大学, 医学(系)研究科(研究院), 講師 (20254279)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Takeshi  中部大学, 生物機能開発研究所, 教授 (10043324)
KOHRI Kenjiro  名古屋市立大学, その他の部局, 学長 (30122047)
TOZAWA Keiichi  名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
SASAKI Shoichi  名古屋市立大学, 大学院医学研究科, 准教授 (50225869)
NAIKI Taku  名古屋市立大学, 大学院医学研究科, 研究員 (50551272)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords温熱治療 / 温熱免疫 / 前立腺癌 / ナノテクノロジー / 磁場 / がん免疫 / 免疫治療
Outline of Final Research Achievements

We developed several years ago new cancer thermotherapy “MCL Heat Therapy”, which is based on the particular character of the magnetite (Fe3O4). The character is generating heat by irradiation of alternative magnetic field. We performed basic research for the purpose of developing new therapy to treat both primary and metastatic lesion by which MCL Heat Therapy and cancer immunotherapy are fused. In vitro, we could not find the enhancement of tumor antigen from prostate cancer cell by heat therapy. However, in vitro, helper T cell and cytotoxic T cell were appeared in tumor tissue by MCL Heat Therapy.
Under the acceptance of Institutional Review Bore of our university, new Heat Therapy with inductive heating machine RF-8 and local injection of MCL was performed for three patients. There were no adverse events.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 Other

All Presentation (3 results)

  • [Presentation] 標準治療が無効となった固形癌の再発巣の治療を目的としたマグネタイト微粒子と誘電加温装置を用いた新規温熱治療の開発2015

    • Author(s)
      河合 憲康
    • Organizer
      第53回 日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2015-10-29 – 2015-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 磁性微粒子を用いて癌転移を治療する

    • Author(s)
      河合 憲康
    • Organizer
      第54回医療ICTに関する座談会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 磁性ナノ粒子を用いた温熱治療の開発と再燃性前立腺がんに対する免疫賦活機構の解明

    • Author(s)
      小林 大地
    • Organizer
      第101回 日本泌尿器科学会総会
    • Place of Presentation
      札幌芸術文化の館(北海道)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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