Investigation of Mechanism of Action of Steroid Sulfatase in Bladder Cancer
| Project/Area Number |
24592406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka City University |
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Principal Investigator |
TAMADA Satoshi 大阪市立大学, 医学(系)研究科(研究院), 講師 (20382179)
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| Co-Investigator(Kenkyū-buntansha) |
WEI Min 大阪市立大学, 医学(系)研究科(研究院), 准教授 (70336783)
KATO Minoru 大阪市立大学, 医学(系)研究科(研究院), 登録医 (30711684)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 膀胱癌 / 浸潤 / アンドロゲン / 膀胱がん |
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| Outline of Final Research Achievements |
we found out that steroid sulfatase (STS), an enzyme involved in androgen synthesis, is an important factor of invasion and prognosis of bladder cancer (BCa) patients. First, we demonstrated that the expression level of STS was significantly higher in muscle invasive BCa compared to non muscle-invasive BCa and the prognosis of STS positive Bca is significantly worse than that of STS negative BCa. Sedond, STS-knock down BCa cells showed less migration and invasion capability. Lastly, we showed that STS is relevant to epithelial to mesenchymal factors such as vimentin and ZEB1.
In conclusion, we showed the possibility that STS is a novel target of BCa treatment.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors2013
Author(s)
Komatsu H, Kakehashi A, Nishiyama N, Izumi N, Mizuguchi S, Yamano S, Inoue H, Hanada S, Chung K, Wei M, et al.
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Journal Title
Cancer Biomark
Volume: 13
Issue: 3
Pages: 171-180
DOI
Related Report
Peer Reviewed
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