Development of immunomodulatory p53-targeted vaccine for mouse model of prostate cancer

• Project/Area Number: 24592409
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kitasato University
• Principal Investigator: SATOH TAKEFUMI 北里大学, 医学部, 講師 (50286332)
• Co-Investigator(Kenkyū-buntansha): TABATA Kenichi 北里大学, 医学部, 講師 (20327414) ; KUROSAKA Shinji 北里大学, 医学部, 助教 (10348568) ; KUBO Makoto 北里大学, 医療衛生学部, 講師 (40464804) ; TSUMURA Hideyasu 北里大学, 医学部, 助教 (20348569)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 前立腺癌 / 転移 / 抗腫瘍免疫 / RTVP-1遺伝子 / in vivo

Outline of Final Research Achievements

The purpose of this preclinical study was to develop an immunomodulatory p53-targeted vaccine for mouse model of prostate cancer. Result of this study, including collaborated research institutions, mechanisms such as induction of cytotoxic T cells was confirmed in this immunomodulatory approach. Further additional analysis are expected.

Research Products

• [Journal Article] Enhanced central memory cluster of differentiation 8+ and tumor antigen-specific T cells in prostate cancer patients receiving repeated in situ adenovirus-mediated suicide gene therapy. (2015)
  • Author(s): Kubo M, Satoh T, Tabata K, Tsumura H, Iwamura M, Baba S, Thompson TC, Obata F
  • Journal Title: Mol Clin Oncol Volume: 3 Issue: 3 Pages: 515-521
  • DOI: 10.3892/mco.2015.519
  • Peer Reviewed
• [Journal Article] Comparison of three different techniques of low-dose-rate seed implantation for prostate cancer. (2015)
  • Author(s): Ishiyama H, Satoh T, Sekiguchi A, Tabata K, Komori S, Tsumura H, Kawakami S, Soda I, Takenaka K, Iwamura M, Hayakawa K
  • Journal Title: J Contemp Brachytherapy Volume: 7 Pages: 3-9
  • DOI: 10.5114/jcb.2015.48603
  • Peer Reviewed
• [Journal Article] Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models (2014)
  • Author(s): Fujita T, Satoh T, Timme TL, Hirayama T, Zhu JX, Kusaka N, Naruishi K, Yang G, Goltsov A, Wang J, Vlachaki MT, Teh BS, Brian Butler E, Thompson TC.
  • Journal Title: Urol Oncol Volume: 32 Pages: 92-100
  • Peer Reviewed
• [Journal Article] Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. (2014)
  • Author(s): Takahashi R., Amano H., Satoh T., Tabata K., Ikeda M., Kitasato H., Akira S., Iwamura M., Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 68 Issue: 1 Pages: 71-77
  • DOI: 10.1016/j.biopha.2013.10.008
  • Peer Reviewed
• [Journal Article] High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term hormonal therapy for high-risk and very high-risk prostate cancer: outcomes after 5-year follow-up. (2014)
  • Author(s): Ishiyama H, Satoh T, Kitano M, Tabata KI, Komori S, Ikeda M, Soda I, Kurosaka S, Sekiguchi A, Kimura M, Kawakami S, Iwamura M, Hayakawa K
  • Journal Title: J Radiat Res Volume: 55 Issue: 3 Pages: 509-517
  • DOI: 10.1093/jrr/rrt128
  • Peer Reviewed
• [Journal Article] EORTC QLQ-BM22 and QLQ-C30 quality of life scores in patients with painful bone metastases of prostate cancer treated with strontium-89 radionuclide therapy (2012)
  • Author(s): Kurosaka S, Satoh T, Chow E, Asano Y, Tabata KI, Kimura M, Tsumura H, Matsumoto K, Ishiyama H, Inoue Y, Hayakawa K, Baba S
  • Journal Title: ANNALS OF NUCLEAR MEDICINE Volume: 26(6) Pages: 485-491
  • NAID: 10030949486
• [Journal Article] Deaths within 12 months after <SUP>125</SUP>I implantation for brachytherapy of prostate cancer: An investigation of radiation safety issues in Japan (2003-2010) (2012)
  • Author(s): Takefumi Satoh,Hidetoshi Yamanaka,Takashi Yamashita,Manabu Aoki,Shin Egawa,et al.,
  • Journal Title: Brachytherapy Volume: 11(3) Pages: 192-196
  • Peer Reviewed
• [Journal Article] Matched-pair analysis and dosimetric variations of two types of software for interstitial permanent brachytherapy for prostate cancer. (2012)
  • Author(s): Ishiyama H, Nakamura R, Satoh T, Tanji S, Teh BS, Uemae M, Baba S, Hayakawa K.
  • Journal Title: Medical Dosimetry Volume: 7 Pages: 84-86
  • Peer Reviewed
• [Journal Article] Diffusion-weighted imaging of local recurrent prostate cancer after radiation therapy: comparison with 22-core three-dimensional prostate mapping biopsy (2012)
  • Author(s): Hara T, Inoue Y, Satoh T, Ishiyama H, Sakamoto S, Woodhams R, Baba S, Hayakawa K
  • Journal Title: MAGNETIC RESONANCE IMAGING Volume: 30(8) Pages: 1091-1098
  • Peer Reviewed
• [Journal Article] Association between Preoperative Erectile Dysfunction and Prostate Cancer Features-An Analysis from the Duke Prostate Center Database (2012)
  • Author(s): Masaki Kimura,Lionel L. Banez,Leah Gerber,Jim Qi,Matvey Tsivian,Stephen J.Freedland,Takefumi Satoh,Thomas J. Polascik,Shiro Baba,Judd W. Moul
  • Journal Title: Journal of Sexual Medicine Volume: 9(4) Pages: 1174-1181
  • Peer Reviewed
• [Presentation] 前立腺がん患者におけるBone Health (2014)
  • Author(s): 佐藤威文
  • Organizer: 第６６回日本泌尿器科学会西部総会（教育セミナー）
  • Place of Presentation: 倉敷市芸文館、倉敷アイビースクエア(岡山県倉敷市)
  • Year and Date: 2014-11-18
  • Invited
• [Presentation] 前立腺がん患者におけるBone Health (2014)
  • Author(s): 佐藤威文
  • Organizer: 第64回日本泌尿器科学会中部総会
  • Place of Presentation: アクトシティ浜松、コングレスセンター 、オークラアクトシティホテル浜松(静岡県浜松市)
  • Year and Date: 2014-10-17
  • Invited
• [Presentation] 泌尿器科領域PET診断の cutting edge (2014)
  • Author(s): 佐藤威文
  • Organizer: 第79回日本泌尿器科学会東部総会（シンポジウム）
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-10-13
  • Invited
• [Presentation] 前立腺がん患者におけるBone Health：見えてきた診療のポイントと課題 (2014)
  • Author(s): 佐藤威文
  • Organizer: 第52回日本癌治療学会学術集会（教育セミナー）
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-08-29
  • Invited
• [Presentation] 去勢抵抗性前立腺癌に対する 新しい治療戦略と課題 (2014)
  • Author(s): 佐藤威文
  • Organizer: 青森泌尿器科医会講演会（招待講演）
  • Place of Presentation: ホテル青森(青森県青森市)
  • Year and Date: 2014-08-25
  • Invited
• [Presentation] 去勢抵抗性前立腺癌に対する新しい治療戦略と課題 (2014)
  • Author(s): 佐藤威文
  • Organizer: 横浜市泌尿器科医会
  • Place of Presentation: 横浜ベイシェラトンホテル&タワーズ(神奈川県横浜市)
  • Year and Date: 2014-06-24
  • Invited
• [Presentation] 前立腺癌治療Up to Date (2014)
  • Author(s): 佐藤威文
  • Organizer: 第102回 日本泌尿器科学会総会（教育セミナー）
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2014-04-25
  • Invited
• [Presentation] 前立腺癌に対する新たな骨転移治療 (2013)
  • Author(s): 佐藤威文
  • Organizer: 福井県泌尿器科医会講演会
  • Place of Presentation: 福井
  • Invited
• [Presentation] 尿路悪性腫瘍におけるBone management (2013)
  • Author(s): 佐藤威文
  • Organizer: Bone management symposium for Urology
  • Place of Presentation: 東京 目黒
  • Invited
• [Presentation] 腫瘍核医学をいかにして活用するか (2013)
  • Author(s): 佐藤威文
  • Organizer: 神奈川PET/SPECT研究会
  • Place of Presentation: 神奈川 横浜
  • Invited
• [Presentation] 進行前立腺がんの治療（卒後教育プログラム） (2013)
  • Author(s): 佐藤威文
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 前立腺癌に対する新たな治療戦略（イブニングセミナー） (2013)
  • Author(s): 佐藤威文
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] Office Urologyにおける去勢抵抗性前立腺がん治療 (2013)
  • Author(s): 佐藤威文
  • Organizer: 日本泌尿器科医会神奈川支部講演会
  • Place of Presentation: 神奈川 横浜
  • Invited
• [Presentation] 限局性前立腺がんの診断と治療
  • Author(s): 佐藤威文
  • Organizer: 第77回日本泌尿器科学会東部総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 前立腺癌の骨転移に対する治療戦略
  • Author(s): 佐藤威文
  • Organizer: 第13回庄内泌尿器科セミナー
  • Place of Presentation: 山形
  • Invited
• [Presentation] 去勢抵抗性前立腺癌の治療戦略～内分泌療法の可能性と限界～
  • Author(s): 深貝隆志、佐藤直秀、溝上敦、鈴木啓悦、川上理、小坂威雄、上村博司、木村剛、佐藤威文
  • Organizer: 第19回東京前立腺癌フォーラム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 高齢ｍＣＲＰＣ患者に対する治療ストラタジー
  • Author(s): 佐藤威文
  • Organizer: 第39回尿路悪性腫瘍研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 前立腺癌に対する高線量率組織内照射(HDR):Fo-cal therapyを含めた新たなアプローチについて
  • Author(s): 佐藤威文、田畑健一、池田勝臣、木村将貴、黒坂 眞二、藤田哲夫、松和将、石山博條、北野雅史、浅野雄二、井上優介、早川和重、馬場志郎
  • Organizer: 第100回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Invited