Development of immunomodulatory p53-targeted vaccine for mouse model of prostate cancer
Project/Area Number |
24592409
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Kitasato University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
TABATA Kenichi 北里大学, 医学部, 講師 (20327414)
KUROSAKA Shinji 北里大学, 医学部, 助教 (10348568)
KUBO Makoto 北里大学, 医療衛生学部, 講師 (40464804)
TSUMURA Hideyasu 北里大学, 医学部, 助教 (20348569)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 前立腺癌 / 転移 / 抗腫瘍免疫 / RTVP-1遺伝子 / in vivo |
Outline of Final Research Achievements |
The purpose of this preclinical study was to develop an immunomodulatory p53-targeted vaccine for mouse model of prostate cancer. Result of this study, including collaborated research institutions, mechanisms such as induction of cytotoxic T cells was confirmed in this immunomodulatory approach. Further additional analysis are expected.
|
Report
(4 results)
Research Products
(28 results)
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[Journal Article] Comparison of three different techniques of low-dose-rate seed implantation for prostate cancer.2015
Author(s)
Ishiyama H, Satoh T, Sekiguchi A, Tabata K, Komori S, Tsumura H, Kawakami S, Soda I, Takenaka K, Iwamura M, Hayakawa K
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Journal Title
J Contemp Brachytherapy
Volume: 7
Pages: 3-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models2014
Author(s)
Fujita T, Satoh T, Timme TL, Hirayama T, Zhu JX, Kusaka N, Naruishi K, Yang G, Goltsov A, Wang J, Vlachaki MT, Teh BS, Brian Butler E, Thompson TC.
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Journal Title
Urol Oncol
Volume: 32
Pages: 92-100
Related Report
Peer Reviewed
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[Journal Article] High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term hormonal therapy for high-risk and very high-risk prostate cancer: outcomes after 5-year follow-up.2014
Author(s)
Ishiyama H, Satoh T, Kitano M, Tabata KI, Komori S, Ikeda M, Soda I, Kurosaka S, Sekiguchi A, Kimura M, Kawakami S, Iwamura M, Hayakawa K
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Journal Title
J Radiat Res
Volume: 55
Issue: 3
Pages: 509-517
DOI
Related Report
Peer Reviewed
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[Journal Article] EORTC QLQ-BM22 and QLQ-C30 quality of life scores in patients with painful bone metastases of prostate cancer treated with strontium-89 radionuclide therapy2012
Author(s)
Kurosaka S, Satoh T, Chow E, Asano Y, Tabata KI, Kimura M, Tsumura H, Matsumoto K, Ishiyama H, Inoue Y, Hayakawa K, Baba S
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Journal Title
ANNALS OF NUCLEAR MEDICINE
Volume: 26(6)
Pages: 485-491
NAID
Related Report
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