Resistance to mTOR inhibitor in metastatic dialysis-related renal cell carcinoma

• Project/Area Number: 24592410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: RYUICHI Mizuno 慶應義塾大学, 医学部, 講師 (60383824)
• Co-Investigator(Kenkyū-buntansha): OYA Mototsugu 慶應義塾大学, 医学部, 教授 (00213885) ; ASANUMA Hiroshi 慶應義塾大学, 医学部, 講師 (70245570)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 透析腎癌 / mTOR / 腎細胞癌 / 分子標的治療 / mTOR阻害薬

Outline of Final Research Achievements

In dialysis-related renal cell carcinoma, mTOR was more strongly activated compared with conventional renal cell carcinoma. In addition, constitutive activation was also found in renal tubular cell in dialysis kidney, which would affect dialysis-related cancer initiation. Tyrosine kinase inhibitors accelerated mTOR activation in dialysis-related renal cell carcinoma.

Research Products

• [Journal Article] Activity of axitinib in patients with metastatic renal cell carcinoma previously treated with both vascular endothelial growth factor receptor tyrosine-kinase inhibitor and mammalian target of rapamycin inhibitor (2014)
  • Author(s): Ryuichi Mizuno M.D., Akira Miyajima M.D. and Mototsugu Oya M.D.
  • Journal Title: International Journal of Urology Volume: 21 Issue: 7 Pages: 740-740
  • DOI: 10.1111/iju.12414
  • Peer Reviewed
• [Journal Article] Prognostic significance of high nuclear grade in patients with pathologic T1a renal cell carcinoma. (2012)
  • Author(s): Suzuki K, Mizuno R, Mikami S, Tanaka N, Kanao K, Kikuchi E, Miyajima A, Nakagawa K, Oya M.
  • Journal Title: Jpn J Clin Oncol. Volume: 42(9) Issue: 9 Pages: 831-835
  • DOI: 10.1093/jjco/hys109
  • Peer Reviewed
• [Presentation] 透析腎癌におけるmTORの活性化の検討 (2014)
  • Author(s): 水野隆一、森田伸也、香野日高、中川健、林松彦、大家基嗣
  • Organizer: 第５９回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] 進行性腎細胞癌に対してチロシンキナーゼ阻害薬およびmTOR阻害薬投与後にアキシチニブを使用した症例の検討 (2014)
  • Author(s): 水野隆一、森田伸也、小坂威雄、香野日高、篠島利明、菊地栄次、浅沼宏、宮嶋哲、中川健、大家基嗣
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2014-04-24 – 2014-04-27