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Combination therapy using cancer vaccine, antigen-specific CTL and an anticancer drug for renal cell carcinoma

Research Project

Project/Area Number 24592415
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionAichi Medical University

Principal Investigator

Yoshikawa Kazuhiro  愛知医科大学, 医学部, 教授 (60109759)

Research Collaborator SUZUKI Susumu  
KASHIWAGI Takahiro  
NISHIO Mayako  
NISHINO Tokiko  
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords免疫治療 / 細胞治療 / 併用療法 / 抗がん剤 / CTL / 細胞療法 / 免疫療法 / ワクチン
Outline of Final Research Achievements

In this study, we tried to improve immune-cell therapy for cancer by improvement of an amplification system of cytotoxic T-cells (CTL) activated with cancer peptide vaccine and, combination with CTL and anticancer drugs.
CTLs were able to induce and expand in efficiently using cancer peptide vaccine as activation antigen. The influence of anticancer drugs for CTLs were tested using CTLs activated with a CMV peptide. Docetaxel, Gemcitabin and Cisplatin did not show any influence for reactivity of CTL, but showed inhibition activity for proliferation. These results showed that Docetaxel, Gemcitabin and Cisplatin were able to use with CTLs for treatment with cancer patients, but not combination with peptide vaccines. Iressa, Sorafenib and 5-FU did not show any influence for reactive activity and proliferation of CTL, and direct cytotoxicity for CTLs. These results indicate that these drugs can be used with CTLs and peptide vaccines for the treatment of cancer patients.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Current status of immunotherapy.2016

    • Author(s)
      Suzuki S, Ishida T, Yoshikawa K and Ueda R.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 46 Issue: 3 Pages: 191-203

    • DOI

      10.1093/jjco/hyv201

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activated cytotoxic T-lymphocyte immunotherapy is effective for advanced oral and maxillofacial cancers.2014

    • Author(s)
      Ohtani T, Yamada Y, Furuhashi A, Ohmura Y, Nakamura S, Kato H, Yoshikawa K, Kazaoka Y
    • Journal Title

      Int J Oncol.

      Volume: 45 Issue: 5 Pages: 2051-2057

    • DOI

      10.3892/ijo.2014.2599

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The therapeutic potential of a novel PSMA antibody and its IL-2 conjugate in prostate cancer2014

    • Author(s)
      Sugimoto Y, Hirota M, Yoshikawa K, Sumitomo M, Nakamura K, Ueda R, Niwa R, Suzawa T, Yamasaki M, Shitara K, Kato T, Nakamura K.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 89-97

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systemic transduction of p16INK4A antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts2013

    • Author(s)
      Shimazui T, Yoshikawa K, Miyazaki J, Kojima T, Inai H, Ando S, Uemura H, Uchida K, Nishiyama H
    • Journal Title

      Int. J. Oncol

      Volume: Vo l .42 Issue: 2 Pages: 543-54

    • DOI

      10.3892/ijo.2012.1752

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical application of anti-CCR4 monoclonal antibody2014

    • Author(s)
      Ryuzo Ueda, Susumu Suzuki, Kazuhiro Yoshikawa, Takashi Ishida
    • Organizer
      The 45th International Symposium of the PrincessTakamatsu Cancer Research Fund
    • Place of Presentation
      パレスホテル東京
    • Year and Date
      2014-11-18 – 2014-11-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 頭頸部扁平上皮癌(HNSCC)における5-フルオロウラシル(5-FU)併用免疫療法2014

    • Author(s)
      西尾麻矢子、鈴木進、大村元伸、山田陽一、上田龍三、吉川和宏、風岡宜暁
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of CTL preparation kit for adoptive T cell Immunotherap2012

    • Author(s)
      Suzuki S, Yoshikawa K, Takahashi Y, Kojima S, Ueda R
    • Organizer
      20th Annual Cancer Research Institutte International Symposium “Cancer Immunotherapy 2012”
    • Place of Presentation
      New York
    • Related Report
      2012 Research-status Report
  • [Book] Inflammation and Immunity in Cancer2015

    • Author(s)
      Suzuki S, Ishida T, Yoshikawa K, Ueda R
    • Total Pages
      268
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Inflammation and Immunity in Cancer2015

    • Author(s)
      Susumu Suzuki, Takashi Ishida, Kazuhiro Yoshikawa, Ryuzo Ueda
    • Total Pages
      268
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2023-03-16  

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