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Development of photoacoustic imaging system for improved real-time visualization of neurovascular bundle during radical prostatectomy

Research Project

Project/Area Number 24592418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNational Defense Medical College

Principal Investigator

HORIGUCHI Akio  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (20286553)

Co-Investigator(Kenkyū-buntansha) ISHIHARA Miya  防衛医科大学校, 医用工学講座, 教授 (30505342)
ASANO Tomohiko  防衛医科大学校, 泌尿器科学講座, 教授 (40167226)
HIRASAWA Takeshi  防衛医科大学校, 医用工学講座, 助教 (60583086)
Research Collaborator TSUJITA Kazuhiro  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords前立腺癌 / 神経温存 / 光音響画像 / 画像診断 / 根治的前立腺摘除術
Outline of Final Research Achievements

Photoacoustic imaging (PAI) enables one to visualize the distribution of hemoglobin and acquire a map of microvessels without using contrast agents. We developed an imaging system equipped with a conventional linear PAI probe and a transrectal ultrasound (TRUS) type of PAI probe and examined whether PAI helps visualize periprostatic microvessels and improves visualization of the neurovascular bundle (NVB) during radical prostatectomy (RP). The images of periprostatic tissues from RP specimens showed substantial signals especially strong on the posterolateral surface of the prostate. Periprostatic tissues monitored intraoperatively also showed strong signals on the posterolateral surface of the prostate and clearly demonstrated the location and extent of the NVB better than does TRUS alone, suggesting that PAI could be an imaging modality useful in nerve-sparing RP.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Presentation (3 results) (of which Invited: 1 results)

  • [Presentation] Development of photoacoustic imaging system for improved real-time visualization of neurovascular bundle during radical prostatectomy2014

    • Author(s)
      Akio Horiguchi, Kazuhiro Tsujita, Kaku Irisawa, Tadashi Kasamatsu, Makoto Kawaguchi, Keiichi Ito, Tomohiko Asano, Hitoshi Tsuda, Miya Ishihara
    • Organizer
      Annual meeting of American Urological Association
    • Place of Presentation
      Orland
    • Year and Date
      2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of photoacoustic imaging system for improved real-time visualization of neurovascular bundle during radical prostatectomy2014

    • Author(s)
      Akio Horiguchi, Kazuhiro Tsujta, Kaku Irisawa, Tadashi Kasamatsu, Makoto Kawaguchi, Keiichi Ito, Tomohiko Asano, Hitoshi Tsuda, Miya Ishihara
    • Organizer
      2014 Annual meeting of American Urological Association
    • Place of Presentation
      Orland
    • Related Report
      2013 Research-status Report
  • [Presentation] 根治的前立腺全摘術における的確な神経温存のための光音響画像化技術の有用性2013

    • Author(s)
      堀口明男、辻田和宏、川口真、伊藤敬一、淺野友彦
    • Organizer
      第27回日本泌尿器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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