The evaluation of the function with Manserin in prostate cancer
| Project/Area Number |
24592419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
SOGA NORIHITO 愛知県がんセンター(研究所), 腫瘍医化学部, 研究員 (60332714)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Masaaki 三重大学, 医学系研究科, 教授 (80302404)
SUGIMURA Yoshiki 三重大学, 医学系研究科, 教授 (90179151)
ISHII Kenichiro 三重大学, 医学系研究科, 助教 (90397513)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 前立腺癌 / 神経内分泌分化 / マンセリン / 細胞増殖 / 血管新生 / manserin / 神経内分泌様分化誘導 / 前立腺がん / 神経内分泌化 / Manserin |
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| Outline of Final Research Achievements |
The expression levels of manserin were quite different in LNCaP cells and sublines, high level in LNCaP and relative low level in F10. Additionally, manserin may induce NE differentiation in LNCaP cells associated with increased expression of vascular endothelial growth factor, but stimulated proliferation in F10 cells. Therefore, our data supported that manserin contributed to cancer progression via multiple functions, including stimulation of angiogenesis and proliferation.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] A genome-wide association study of serum levels of prostate specific antigen in the Japanese population.2014
Author(s)
Chikashi Terao, Naoki Terada, Keitaro Matsuo, Takahisa Kawaguchi, Koji Yoshimura, Norio Hayashi, Masakazu Shimizu, Norihito Soga, Meiko Takahashi, Nagahama Cohort Study Group, Yoshihiko Kotoura, Ryo Yamada, Osamu Ogawa, Fumihiko Matsuda.
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Journal Title
J Med Genet
Volume: 51
Issue: 8
Pages: 530-536
DOI
Related Report
Peer Reviewed
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