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Creation of chronic cystitis animal model which mimics interstitial cystitis and evaluation of intravesical instillation of adipose derived stem cell to IC model bladder

Research Project

Project/Area Number 24592422
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionThe University of Tokyo

Principal Investigator

NIIMI Aya  東京大学, 医学部附属病院, 助教 (00376451)

Co-Investigator(Kenkyū-buntansha) NOMIYA Akira  東京大学, 医学部泌尿器外科学, 助教 (30372379)
NISHIMATUS Hiroaki  東京大学, 医学部泌尿器外科学, 准教授 (60251295)
IGAWA Yasuhiko  東京大学, 医学部コンチネンス医学講座, 特任教授 (40159588)
HOMMA Yukio  東京大学, 医学部泌尿器外科学, 教授 (40165626)
鈴木 越  聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (40313134)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Etsu  聖マリアンナ医科大学, 難病治療研究センター, 講師 (40313134)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords泌尿器科学 / 排尿機能学 / 間質性膀胱炎
Outline of Final Research Achievements

Interstitial cystitis are refractory disease with unknown etiology. There is no radical treatment so far. The aim of our study is to create disease model animal of chronic inflammation and investigate the effectiveness of intravesical infusion of adipose stem cells on the disease model animal.
First, we have tried to create a chronic cystitis rats and mice model in the beginning. Lipopolysaccharide derived from E. coli and protamine sulfate was instilled into mourine bladder to destroy the mucosal surface, and inflammation was identified histologically, in 2013. Next year, we performed the functional study by bladder cystometry. A result, although the model showed frequent urination, voided volume did not decreased and failed to show similarity with interstitial cystitis in functional study.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) (of which Invited: 8 results) Book (1 results)

  • [Journal Article] Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve injury in Mice2015

    • Author(s)
      Etsu Suzuki, Hiroaki Nishimatsu, Aya Niimi, Akira Nomiya, Hiroshi Fukuhara, Haruki Kume, Yukio Homma
    • Journal Title

      PLOS ONE

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipose-derived stem cells stimulate reendothelialization in stented rat abdominal aorta.2014

    • Author(s)
      Sato T, Takahashi M, Fujita D, Oba S, Nishimatsu H, Nagano T, Suzuki E.
    • Journal Title

      Circulation Journal

      Volume: 78 Pages: 1762-1769

    • NAID

      130003391139

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis.2013

    • Author(s)
      Homma Y, Nomiya A, Tagaya M, Oyama T, Takagaki K, Nishimatsu H, Igawa Y.
    • Journal Title

      J Urol.

      Volume: 190(5) Issue: 5 Pages: 1925-1931

    • DOI

      10.1016/j.juro.2013.05.049

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム:難治性過活動膀胱/間質性膀胱炎に対する治療2015

    • Author(s)
      新美文彩
    • Organizer
      日本泌尿器科学会東部総会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25 – 2015-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] イブニングセミナー(演題名未定)2015

    • Author(s)
      新美文彩
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シンポジウム睡眠障害と夜間頻尿の密接な関係:夜間頻尿の疫学と病態2015

    • Author(s)
      新美文彩
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2015-07-02 – 2015-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 過知覚膀胱質問票(HSBSS)の初期的検討2015

    • Author(s)
      新美文彩
    • Organizer
      第103回 日本泌尿器科学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-04-20 – 2015-04-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical management of interstitial cystitis – initial assessment to long-term outcomes2015

    • Author(s)
      Aya Niimi
    • Organizer
      SATURN
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] OUTCOMES OF HYDRODISTENSION WITH OR WITHOUT FULGURATION FOR INTERSTITIAL CYSTITIS AND RISK FACTORS PREDICTING THERAPEUTIC FAILURE2014

    • Author(s)
      Aya Niimi
    • Organizer
      International Continence Society Annual Meeting
    • Place of Presentation
      Rio De Janeiro, Brazil
    • Year and Date
      2014-10-20 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ハンナ病変凝固術の効果持続期間に影響を与える因子の検討2014

    • Author(s)
      新美文彩
    • Organizer
      第21回排尿機能学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病モデルラット2014

    • Author(s)
      新美文彩
    • Organizer
      日本性機能学会第25回学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ワークショップ;間質性膀胱炎に対する局所療法のアウトカム2014

    • Author(s)
      新美文彩
    • Organizer
      第102回 日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cystoscopic findings and Hydrodistension2013

    • Author(s)
      Aya Niimi
    • Organizer
      The 8th Pan- Pacific Continence Society Meeting
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] EXPRESSION OF AND LOCALIZATION OF ESTROGEN RECEPTOR BETA IN IC/PBS BLADDER2013

    • Author(s)
      Aya Niimi, Akira Nomiya, Yasuhiko Igawa, Yukio Homma
    • Organizer
      42th International Continence Society Annual Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Cystoscopic findingsd and Hydrodistention of interstitial cystitis2013

    • Author(s)
      新美文彩
    • Organizer
      The 8th Pan-Pacific Continence Society(PPCS) Meeting
    • Place of Presentation
      釜山 韓国
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The Use of Tramadol for Refractory Interstitial Cystitis: Retrospective Analysis of Fifteen Cases.2013

    • Author(s)
      新美文彩
    • Organizer
      The 3rd ICICJ
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Title: Relationship between penile / urethral pain and pathological change in IC/PBS male patients’ urethra.2012

    • Author(s)
      新美文彩
    • Organizer
      International Continence Society Annual Meeting 2012
    • Place of Presentation
      北京 中国
    • Related Report
      2012 Research-status Report
  • [Presentation] 間質性膀胱炎の治療抵抗性のリスク因子

    • Author(s)
      新美 文彩
    • Organizer
      間質性膀胱炎研究会
    • Place of Presentation
      東京(トラストシティカンファレンス)
    • Related Report
      2013 Research-status Report
  • [Book] LUTS診療ロードマップ2015

    • Author(s)
      新美文彩
    • Total Pages
      277
    • Publisher
      メジカルビュー
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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