| Project/Area Number |
24592423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Etsu 聖マリアンナ医科大学, 医学系研究科, 講師 (40313134)
TAKAHASHI Masao 東京大学医学部附属病院, 循環器内科, 助教 (00447418)
NOMIYA Akira 東京大学医学部附属病院, 泌尿器外科学, 助教 (30372379)
HIRATA Yasunobu 東京大学医学部附属病院, 循環器内科, 准教授 (70167609)
新美 文彩 東京大学, 医学部附属病院, 助教 (00376451)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脂肪幹細胞 / 勃起不全治療 / 海綿体再生 / アドレノメジュリン |
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| Outline of Final Research Achievements |
The aim of this study is to explore a better treatment for ED, we examined whether combination of AM and angiopoietin-1 (Ang-1) was more effective to treat ED than treatment with AM alone or Ang-1 alone. We also compared the effect of the combination therapy with that of treatment with vascular endothelial growth factor-A (VEGF-A).
Combination therapy with AM and Ang-1 potently restored erectile function and normal morphology of the cavernous body compared with VEGF-A administration. This combination therapy will be useful to treat ED patients with a severely damaged cavernous body.
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