Roles of prostaglandin receptor subtype EP4 in the induction of overactive bladder
| Project/Area Number |
24592428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
ARAKI Isao 滋賀医科大学, 医学部, 客員教授 (50252424)
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| Co-Investigator(Kenkyū-buntansha) |
TSURU Teruhiko 滋賀医科大学, 医学部, 助教 (90625675)
KAGEYAMA Susumu 滋賀医科大学, 医学部, 講師 (50378452)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Masayuki 山梨大学, 大学院医学工学総合研究部, 教授 (80197318)
KOBAYASHI Hideki 山梨大学, 医学部付属病院, 助教 (50402053)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | プロスタグランジン / 膀胱 / 排尿 / 知覚 / 求心路 / 平滑筋 |
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| Outline of Final Research Achievements |
EP4 receptors were largely expressed in bladders with outlet obstruction (BOO) but absent in controls. Activation of the EP4 receptors in bladders with BOO suppressed detrusor contraction and afferent activity. EP4 receptors expressed in the bladder epithelium might regulate neuromodulator release from the epithelium. These results strongly suggest that EP4 receptor upregulation in the BOO bladder participates in a compensatory mechanism to counteract the storage dysfunction caused by BOO.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Muscarinic receptor binding of the novel radioligand, [3H]imidafenacin in the human bladder and parotid gland.2014
Author(s)
Yoshida A, Kuraoka S, Ito Y, Okura T, Deguchi Y, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Yamada S
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Journal Title
J Pharmacol Sci
Volume: 124
Pages: 40-46
NAID
Related Report
Peer Reviewed
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[Journal Article] Fesoterodine, its active metabolite and tolterodine bind selectively to muscarinic receptors in human bladder mucosa and detrusor muscle2013
Author(s)
Akira Yoshida, Yusuke Fuchihata, Shiori Kuraoka, Ayaka Osano, Atsushi Otsuka, Seiichiro Ozono, Masayuki Takeda, Keisuke Masuyama, Isao Araki, and Shizuo Yamada
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Journal Title
Urology
Volume: 81
Issue: 4
Pages: 920.e1-920.e5
DOI
Related Report
Peer Reviewed
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[Presentation] Add-on effects of dutasreride in men with symptomatic benign prostatic hyperplasia resistant to alpha-blocker monothearpy, special focus on ultra-short term effect.2013
Author(s)
Tsuru T, Araki I, Fujiwara R, Baba M, Hanada H, Yoshida T, Kageyama S, Narita M, Okada Y
Organizer
43rd Annual meeting of the Internationa Continence Society
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] The functional role of EP4 receptors in the rat urinary bladder with outlet obstruction: a possible counteractive mechanism against detrusor overactivity.2012
Author(s)
Zakoji H, Araki I, Beppu M, Yoshiyama M, Kobayashi H, Du S, Takeda M
Organizer
42nd Annual Meeting of International Continence Siciety, , October 15-19, 2012.
Place of Presentation
Beijing, China
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