Central sensitization mechanism depends on microglia participates in Lower Urinary Tract Symption

• Project/Area Number: 24592429
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: TSURU Teruhiko 滋賀医科大学, 医学部, 助教 (90625675)
• Co-Investigator(Kenkyū-buntansha): ARAKI Isao 滋賀医科大学, 医学部, 客員教授 (50252424) ; KAGEYAMA Susumu 滋賀医科大学, 医学部, 講師 (50378452)
• Co-Investigator(Renkei-kenkyūsha): TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 下部尿路機能障害 / 排尿学 / 過活動膀胱 / 間質性膀胱炎 / 脊髄グリア細胞 / 下部尿路障害

Outline of Final Research Achievements

We make an experiment with interstitial cystitis model to certificate the association between microglia and Lower Urinary Tract Symption .
Microgia is stained more than control model by activation makers; GFAP、Iba1、Ox-18、AB144P. Microglia is acivated in interstitial cystitis model. It shows Central sensitization mechanism with microglia is concern with hypersensitivity of bladder.We make a microarray.some gene in interstitial cystitis model are expressed more than in control model. It shows gene of activated maicroglia is included in these.