Pelvic blood flow and lower urinary tract dysfunction

• Project/Area Number: 24592431
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kochi University (2013-2014); Tottori University (2012)
• Principal Investigator: SAITO Motoaki 高知大学, 教育研究部医療学系, 教授 (60273893)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Yukako 鳥取大学, 医学部, 助教 (50032214)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 骨盤内血流 / 膀胱 / 前立腺 / 前立腺過形成 / 排尿筋過活動 / SHR / 骨盤内虚血 / 慢性虚血 / 下部尿路症 / 膀胱血流

Outline of Final Research Achievements

A decreased prostatic blood flow could be one of the risk factors for overactive bladder/ detrusor hyperactivity and benign prostatic hyperplasia/benign prostatic enlargement. The spontaneously hypertensive rat (SHR) shows a chronic pelvic ischemia and detrusor hyperactivity and hyperplastic morphological abnormalities in the ventral prostate. Chronic treatment with nicorandil, silodosin, hydroxyfasudil and olmesartan improved the pelvic blood flow, bladder dysfunction and prostatic hyperplasia in the SHR. These drugs can ameliorate the progression of bladder dysfunction as well as prostatic hyperplasia through an increase in the pelvic blood flow.

Research Products

• [Journal Article] Olmesartan ameliorates urinary dysfUnction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress (2014)
  • Author(s): Shimizu S, Saito M, Oiwa H, Ohmasa F, Tsounapi P, Oikawa R, Dimitriadis F, Martin TD, Satoh I, Kinoshita Y, Tomita S
  • Journal Title: Neurourology and Urodynamics Volume: 33 Issue: 3 Pages: 350-7
  • DOI: 10.1002/nau.22405
  • Peer Reviewed
• [Journal Article] Prostatic ischemia induces ventral prostatic hyperplasia in the SHR; possible mechanism of development of BPH. (2014)
  • Author(s): Saito M, Tsounapi P, Oikawa R, Shimizu S, Honda M, Sejima T, Kinoshita Y, Tomita S.
  • Journal Title: Sci Rep Volume: 22 Issue: 1 Pages: 3822-3822
  • DOI: 10.1038/srep03822
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction: are these conditions related to vascular dysfunction? (2014)
  • Author(s): Shimizu S, Tsounapi P, Shimizu T, Honda M, Inoue K, Dimitriadis F, Saito M.
  • Journal Title: Int J Urol Volume: 21 Issue: 9 Pages: 856-64
  • DOI: 10.1111/iju.12501
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of an angiotensin II receptor blocker and a calcium channel blocker on hypertension associated penile dysfunction in a rat model (2014)
  • Author(s): Shimizu S, Tsounapi P, Honda M, Dimitriadis F, Taniuchi K, Shimizu T, Inoue K, Saito M.
  • Journal Title: Biomed Res Volume: 35 Pages: 215-21
  • NAID: 130004470870
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 膀胱虚血と膀胱機能障害（総論） (2014)
  • Author(s): 齊藤源顕、本田正史、井上啓史
  • Journal Title: 排尿障害プラクティス Volume: 22 Pages: 62-66
• [Journal Article] Effect of silodosin on detrusor overactivity in the male spontaneously hypertensive rat (2012)
  • Author(s): Inoue S, Saito M, Tsounapi P, Dimitriadis F, Ohmasa F, Kinoshita Y, Satoh K, Takenaka A
  • Journal Title: BJU Int Volume: 110 (2 Pt B) Issue: 2b
  • DOI: 10.1111/j.1464-410x.2011.10814.x
  • Peer Reviewed
• [Journal Article] Hydroxyfasudil ameliorates bladder dysfunction in the male spontaneously hypertensive rat (2012)
  • Author(s): Inoue S, Saito M, Takenaka A
  • Journal Title: Urology Volume: 79 Issue: 5 Pages: 1186.e9-1186.e14
  • DOI: 10.1016/j.urology.2011.12.032
  • Peer Reviewed
• [Journal Article] Nicorandil ameliorates hypertension-related bladder dysfunction in the rat (2012)
  • Author(s): Saito M, Ohmasa F, Tsounapi P, Inoue S, Dimitriadis F, Kinoshita Y, Satoh K
  • Journal Title: Neurourol Urodyn Volume: 31 Issue: 5 Pages: 695-701
  • DOI: 10.1002/nau.21213
  • Peer Reviewed
• [Presentation] Selective α1A-adrenoceptor blocker silodosin decreases the prostatic growth in the spontaneously hypertensive rat (2015)
  • Author(s): Shogo Shimizu, Panagiota Tsounapi, Takahiro Shimizu, Youichirou Higashi, Kumiko Nakamura, Felix Holmstrom, Motoaki Saito
  • Organizer: 第88回 日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] 低活動膀胱～病態、診断、治療～ (2014)
  • Author(s): 齊藤源顕
  • Organizer: 第13回LUTS Expert Forum
  • Place of Presentation: 六本木アカデミーヒルズ49（東 京）
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] 前立腺肥大症に対するα1受容体遮断薬シロドシンの前立腺血流を介した抑制効果 (2014)
  • Author(s): 清水翔吾、清水孝洋、谷内恵介、東洋一郎、中村久美子、Holmstrom Felix、 齊藤源顕
  • Organizer: 第67回 日本薬理学会西南部会
  • Place of Presentation: 産業医科大学（北九州）
  • Year and Date: 2014-11-23
• [Presentation] Angiotensin II type 1 receptor blocker, olmesartan ameliorates corpus cavernosum damages in the spontaneously hypertensive rat (2014)
  • Author(s): Holmstrom Felix, Shimizu Shogo, Shimizu Takahiro, Higashi Youichirou, Nakamura Kumiko, Saito Motoaki
  • Organizer: 第67回 日本薬理学会西南部会
  • Place of Presentation: 産業医科大学（北九州）
  • Year and Date: 2014-11-23
  • Invited
• [Presentation] α1遮断薬の蓄尿症状改善メカニズムを探る (2014)
  • Author(s): 齊藤 源顕
  • Organizer: 第66回西日本泌尿器科学会総会
  • Place of Presentation: 倉敷市芸文館・倉敷アイビースクエア（倉敷）
  • Year and Date: 2014-11-06 – 2014-11-08
  • Invited
• [Presentation] The effect of an arb, olmesartan on hypertension related corpus cavernsartanosum dysfunction in the spontaneously hypertensive rat (2014)
  • Author(s): Saito M, Shimizu S, Shimizu T
  • Organizer: 44th Annual Meeting of the International Continence Society
  • Place of Presentation: Rio de Janeiro, Federative Republic of Brazil
  • Year and Date: 2014-10-20 – 2014-10-24
• [Presentation] 下部尿路症(LUTS)・前立腺肥大(BPH)・EDと血管機能障害 (2014)
  • Author(s): 齊藤 源顕
  • Organizer: 第64回日本泌尿器科学会中部総会
  • Place of Presentation: アクトシティ浜松コングレスセンター（浜松）
  • Year and Date: 2014-10-17 – 2014-10-19
  • Invited
• [Presentation] 高血圧とLUTS, BPHとED； 実験動物から学んだこと (2014)
  • Author(s): 齊藤 源顕
  • Organizer: 第21回日本排尿機能学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2014-09-17 – 2014-09-20
  • Invited
• [Presentation] α1 受容体遮断薬シロドシンによる前立腺血流量改善を介した前立腺肥大の抑制効果 (2014)
  • Author(s): 清水 翔吾、Tsounapi Panagiota、清水 孝洋、谷内 恵介、本田 正史、井上 啓史、武中 篤、齊藤 源顕
  • Organizer: 第21回日本排尿機能学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] EDと下部尿路症(LUTS)・前立腺肥大：SHRの血流に着目して (2014)
  • Author(s): 齊藤 源顕
  • Organizer: 日本性機能学会第２５回学術総会
  • Place of Presentation: アエル（仙台市情報・産業プラザ）（仙台）
  • Year and Date: 2014-09-04 – 2014-09-06
  • Invited
• [Presentation] Effect of angiotensin II type 1 receptor blocker, olmesartan on corpus cavernosum damages in the spontaneously hypertensive rat (2014)
  • Author(s): Saito M, Shimizu S, Tsounapi P, Shimizu T, Honda M, Sejima T, Takenaka A, Tomita S
  • Organizer: American Urological Association, 109th Annual Meeting
  • Place of Presentation: Orange County Convention Center (Orlando, Florida, USA)
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] アンギオテンシンII受容体遮断薬オルメサルタンの膀胱血流と血圧を介した排尿障害改善効果 (2013)
  • Author(s): 清水翔吾, 齊藤源顕, 大岩晴矩, 大政史弥, ツナピ・パナイオタ, 老川諒, 木下ゆか子, 冨田修平
  • Organizer: 第101回 日本泌尿器科学会総会
  • Place of Presentation: 札幌市
• [Presentation] 前立腺肥大発症のメカニズム：血流量低下と酸化ストレス・シグナルによる分子機構 (2013)
  • Author(s): 清水翔吾, Tsounapi Panagiota, 老川諒, 井口道代, 川本文弥, 井上誠也, 小林直人, 村岡邦康, 本田正史, 武中篤, 冨田修平, 齊藤源顕
  • Organizer: 第20回 日本排尿機能学会大会
  • Place of Presentation: 静岡市
• [Presentation] Selective alpha(1D)-adrenoceptor antagonist, naftopidil improves urinary frequency in the light-cycle due to inhibition of urine production in the spontaneously hypertensive rat (2013)
  • Author(s): Shimizu S, Tsounapi P, Iguchi M, Kawamoto B, Inoue S, Kobayashi N, Muraoka K, Honda M, Takenaka A, Tomita S, Saito M
  • Organizer: 第20回 日本排尿機能学会大会
  • Place of Presentation: 静岡市
• [Presentation] Angiotensin II receptor blocker, olmesartan preserves bladder blood flow and oxidative stress, and improves bladder dysfunction in the spontaneously hypertensive rat (2013)
  • Author(s): Shimizu S, Saito M, Oiwa H, Ohmasa F, Tsounapi P, Oikawa R, Kinoshita Y, Tomita S
  • Organizer: American Urological Association, 108th Annual Meeting
  • Place of Presentation: 米国 サンディエゴ
• [Presentation] Prostatic ischemia induces ventral prostatic hyperplasia in the SHR (2013)
  • Author(s): Saito M, Tsounapi P, Oikawa R, Shimizu S, Honda M, Inoue S, Kinoshita Y, Sejima T, Takenaka A, Tomita S
  • Organizer: 43rd Annual Meeting of the International Continence Society
  • Place of Presentation: スペイン バルセロナ
• [Presentation] Does pelvic ischemia induce ventral prostatic hyperplasia in the SHR? (2013)
  • Author(s): Saito M, Tsounapi P, Oikawa R, Shimizu S, Honda M, Inoue S, Sejima T, Takenaka A, Tomita S
  • Organizer: The 8th Pan-Pacific Continence Society Meeting
  • Place of Presentation: 韓国 釜山
• [Remarks] 高知大学医学部薬理学講座
  • URL: http://www.kochi-ms.ac.jp/~ff_phrmc/index.html