Pelvic blood flow and lower urinary tract dysfunction
| Project/Area Number |
24592431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kochi University (2013-2014)
Tottori University (2012) |
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Principal Investigator |
SAITO Motoaki 高知大学, 教育研究部医療学系, 教授 (60273893)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Yukako 鳥取大学, 医学部, 助教 (50032214)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨盤内血流 / 膀胱 / 前立腺 / 前立腺過形成 / 排尿筋過活動 / SHR / 骨盤内虚血 / 慢性虚血 / 下部尿路症 / 膀胱血流 |
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| Outline of Final Research Achievements |
A decreased prostatic blood flow could be one of the risk factors for overactive bladder/ detrusor hyperactivity and benign prostatic hyperplasia/benign prostatic enlargement. The spontaneously hypertensive rat (SHR) shows a chronic pelvic ischemia and detrusor hyperactivity and hyperplastic morphological abnormalities in the ventral prostate. Chronic treatment with nicorandil, silodosin, hydroxyfasudil and olmesartan improved the pelvic blood flow, bladder dysfunction and prostatic hyperplasia in the SHR. These drugs can ameliorate the progression of bladder dysfunction as well as prostatic hyperplasia through an increase in the pelvic blood flow.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Olmesartan ameliorates urinary dysfUnction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress2014
Author(s)
Shimizu S, Saito M, Oiwa H, Ohmasa F, Tsounapi P, Oikawa R, Dimitriadis F, Martin TD, Satoh I, Kinoshita Y, Tomita S
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Journal Title
Neurourology and Urodynamics
Volume: 33
Issue: 3
Pages: 350-7
DOI
Related Report
Peer Reviewed
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[Presentation] Effect of angiotensin II type 1 receptor blocker, olmesartan on corpus cavernosum damages in the spontaneously hypertensive rat2014
Author(s)
Saito M, Shimizu S, Tsounapi P, Shimizu T, Honda M, Sejima T, Takenaka A, Tomita S
Organizer
American Urological Association, 109th Annual Meeting
Place of Presentation
Orange County Convention Center (Orlando, Florida, USA)
Year and Date
2014-05-16 – 2014-05-21
Related Report
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[Presentation] 前立腺肥大発症のメカニズム：血流量低下と酸化ストレス・シグナルによる分子機構2013
Author(s)
清水翔吾, Tsounapi Panagiota, 老川諒, 井口道代, 川本文弥, 井上誠也, 小林直人, 村岡邦康, 本田正史, 武中篤, 冨田修平, 齊藤源顕
Organizer
第20回 日本排尿機能学会大会
Place of Presentation
静岡市
Related Report
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[Presentation] Selective alpha(1D)-adrenoceptor antagonist, naftopidil improves urinary frequency in the light-cycle due to inhibition of urine production in the spontaneously hypertensive rat2013
Author(s)
Shimizu S, Tsounapi P, Iguchi M, Kawamoto B, Inoue S, Kobayashi N, Muraoka K, Honda M, Takenaka A, Tomita S, Saito M
Organizer
第20回 日本排尿機能学会大会
Place of Presentation
静岡市
Related Report
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[Presentation] Angiotensin II receptor blocker, olmesartan preserves bladder blood flow and oxidative stress, and improves bladder dysfunction in the spontaneously hypertensive rat2013
Author(s)
Shimizu S, Saito M, Oiwa H, Ohmasa F, Tsounapi P, Oikawa R, Kinoshita Y, Tomita S
Organizer
American Urological Association, 108th Annual Meeting
Place of Presentation
米国 サンディエゴ
Related Report
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