| Project/Area Number |
24592434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUJITA Keiji 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50264734)
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| Co-Investigator(Kenkyū-buntansha) |
TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 研究員 (80551267)
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 尿路結石 / 細胞障害 / ミトコンドリア / 酸化ストレス / Cyclophilin D / 細胞傷害 / 腎尿細管細胞傷害 |
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| Outline of Final Research Achievements |
To experimentally evaluate the clinical application of N-methyl-4-isoleucine cyclosporin, a novel selective inhibitor of cyclophilin D activation.In vitro, calcium oxalate monohydrate crystals induced depolarization of the mitochondrial membrane potential, which was remarkably prevented by N-methyl-4-isoleucine cyclosporin. In vivo, ethylene glycol administration induced renal calcium crystallization, oxidative stress, mitochondrial collapse and cell apoptosis in rats, which were significantly prevented by N-methyl-4-isoleucine cyclosporin.
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