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A new treatment agent determining renal calcium crystallization through cyclophilin D activation.

Research Project

Project/Area Number 24592434
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

FUJITA Keiji  名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50264734)

Co-Investigator(Kenkyū-buntansha) TOZAWA Keiichi  名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
YASUI Takahiro  名古屋市立大学, 大学院医学研究科, 教授 (40326153)
OKADA Atsushi  名古屋市立大学, 大学院医学研究科, 講師 (70444966)
HAMAMOTO Shuzo  名古屋市立大学, 大学院医学研究科, 研究員 (80551267)
郡 健二郎  名古屋市立大学, その他部局等, 学長 (30122047)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords尿路結石 / 細胞障害 / ミトコンドリア / 酸化ストレス / Cyclophilin D / 細胞傷害 / 腎尿細管細胞傷害
Outline of Final Research Achievements

To experimentally evaluate the clinical application of N-methyl-4-isoleucine cyclosporin, a novel selective inhibitor of cyclophilin D activation.In vitro, calcium oxalate monohydrate crystals induced depolarization of the mitochondrial membrane potential, which was remarkably prevented by N-methyl-4-isoleucine cyclosporin. In vivo, ethylene glycol administration induced renal calcium crystallization, oxidative stress, mitochondrial collapse and cell apoptosis in rats, which were significantly prevented by N-methyl-4-isoleucine cyclosporin.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Colony-StimulatingFactor-1 Signaling Suppresses Renal Crystal Formation.2015

    • Author(s)
      Taguchi Kazumi, Okada Atsushi, Kitamura Hiroshi, Yasui Takahiro, Naiki Taku, Hamamoto Shuzo, Ando Ryosuke, Mizuno Kentaro, Kawai Noriyasu, Tozawa Keiichi, Asano Kenichi, Tanaka Masato, Miyoshi Ichiro, Kohri Kenjiro
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 25 Issue: 8 Pages: 1680-1697

    • DOI

      10.1681/asn.2013060675

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Developments in the technique of endoscopic combined intrarenal surgery in the prone split-leg position.2014

    • Author(s)
      Shuzo Hamamoto, Takahiro Yasui, Atsushi Okada, Mitsuru Takeuchi, Kazumi Taguchi, Yuta Shibamoto, Yutaka Iwase, Noriyasu Kawai, Keiichi Tozawa, Kohri Kenjiro
    • Journal Title

      Urology

      Volume: 84 Issue: 3 Pages: 565-570

    • DOI

      10.1016/j.urology.2014.04.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel effect of the inhibitor of mitochondrial cyclophilin D activation, N-methyl-4-isoleucine cyclosporin, on renal calcium crystallization2014

    • Author(s)
      Niimi K, Yasui T, Okada A, Hirose Y, Kubota Y, Umemoto Y, Kawai N, Tozawa K, Kohri K
    • Journal Title

      Int J Urol

      Volume: ― Issue: 7 Pages: 707-13

    • DOI

      10.1111/iju.12425

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 経皮的腎砕石術におけるReal-time virtual sonography(RVS)を用いた腎瘻穿刺法の確立2015

    • Author(s)
      浜本周造、安井孝周、奥田奈保子、小岩哲、岡田淳志、神谷浩行、橋本良博、内木拓、藤田圭治、戸澤啓一、岩瀬豊、郡健二郎
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミトコンドリアcyclophilin D をターゲットとした 尿路結石に対する新規治療薬と尿中バイオマーカーの開発2014

    • Author(s)
      新美 和寛
    • Organizer
      第102回日本泌尿器科学会総会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of a new biomarker and treatment strategy for kidney stone disease targeting mitochondrial cyclophilin D activity2014

    • Author(s)
      新美 和寛
    • Organizer
      2014年度米国泌尿器科学会総会
    • Place of Presentation
      Orange County Convention Center (Orlando,USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] ミトコンドリアcyclophilin D をターゲットとした尿路結石に対する 治療薬の開発とバイオマーカーの確立2013

    • Author(s)
      新美 和寛
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      さっぽろ芸術文化の館(札幌)
    • Related Report
      2013 Research-status Report
  • [Presentation] ミトコンドリア傷害から見た尿路結石の形成機序~治療薬の開発とバイオマーカーの 確立~2013

    • Author(s)
      新美 和寛
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 尿路結石の初期形成におけるMitochondrial Permeability Transition Pore開口の作用機序とその予防法の確立。2012

    • Author(s)
      新美 和寛
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 尿路結石の形成におけるミトコンドリアcyclophilin Dの機能解析。2012

    • Author(s)
      新美 和寛
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 尿路結石の初期形成に係わるミトコンドリア崩壊のメカニズムと治療への応用~分子標的治療薬NIM811の開発~。2012

    • Author(s)
      新美 和寛
    • Organizer
      日本尿路結石症学会第22回学術集会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(静岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Activation of cyclophilin D induces the initial process of kidney stone formation via mitochondrial permeability transition pore opening.2012

    • Author(s)
      新美 和寛
    • Organizer
      第32回国際泌尿器科学会(SIU)
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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