| Project/Area Number |
24592435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
MARUYAMA Tetsuji 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50305546)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Kentaro 名古屋市立大学, 大学院医学研究科, 講師 (70448710)
HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134)
KOHRI Kenjiro 名古屋市立大学, その他部局, 学長 (30122047)
KOJIMA Yosiyuki 福島県立医科大学, 医学部, 教授 (60305539)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | KIT陽性細胞 / シェアーストレス / 伸展刺激 / ホローファイバー / 上皮間葉系誘導 / 平滑筋細胞 / 尿路上皮細胞 / 再生医療 / 細胞工学 / 移行上皮細胞 |
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| Outline of Final Research Achievements |
With cytoengineering method, we have made urotherial sheet with functional smooth muscle layer showing regular special pattern. These cells were under laminar flow stimulation exerted shear and stretch stress, and/or electrical stimulation using hollow-fiber cell-culture system. In addition, ES cells were used to induce these urotherial and smooth muscle cell to minimize preparing time and effort.
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