Functional analysis of urinary exosome in ADPKD
| Project/Area Number |
24592439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Juntendo University (2013-2014)
Teikyo University (2012) |
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Principal Investigator |
HORIE Shigeo 順天堂大学, 医学(系)研究科(研究院), 教授 (40190243)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ADPKD / 多発性嚢胞腎 / exosome / microRNA / 尿中microRNA / microvesicle / LC/MS法 / 尿中バイオマーカー / 奇形学 |
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| Outline of Final Research Achievements |
Urinary exosome was isolated from either CKD Gstage4 or ADPKD patients upon consent, and the identified microRNA was compared between these 2 groups. MicroRNAs specific for Wnt/b-catenin/GSK-3, regulating Oncogenes, associated with renal cell carcinoma, tumor suppressor gene, and inhibitory for inflammation were more expressed in ADPKD.
Specific microRNAs identified from urinary exosome of ADPKD patients can be either prognostic or predictive for the clinical course of ADPKD.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.2015
Author(s)
Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC
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Journal Title
Kidney Int
Volume: Epub ahead of print
Issue: 1
Pages: 17-27
DOI
Related Report
Peer Reviewed
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[Journal Article] Maintenance therapy with intravesical bacillus Calmette-Guerin in patients with intermediate- or high-risk non-muscle-invasive bladder cancer.2013
Author(s)
Muto S, Nakajima A, Horiuchi A, Inoue M, China T, Saito K, Isotani S, Hisasue S, Yamaguchi R, Ide H, Horie S.
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Journal Title
Jpn J Clin Oncol
Volume: 43
Pages: 305-313
Related Report
Peer Reviewed
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[Presentation] Novel approach to estimate kidney volumes using computer-assisted segmentation tools in ADPKD.2014
Author(s)
Muto S, Isotani S, Shimoyama H, Kawano H, Masumoto J, Kotera K, Kitamura K, Kimura M, Saito K, Ide H, Yamaguchi R, Horie S.
Organizer
47th Annual Meeting of the American Society of Nephrology
Place of Presentation
Philadelphia
Year and Date
2014-11-12 – 2014-11-16
Related Report
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[Presentation] The relationship between liver cyst volume and QOL in ADPKD.2014
Author(s)
Muto S, Ando M, Nishio S, Narita I, Kamura K, Tsuchiya K, Mochizuki T, Tsuruya K, Ubara Y, Nutahara K, Horie S.
Organizer
The 14th Asian Pacific Congress of Nephrology
Place of Presentation
Tokyo
Year and Date
2014-05-14 – 2014-05-17
Related Report
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[Presentation] The compiling data at the time of enrollment in J-PKD registry.2014
Author(s)
Muto S, Mochizuki T, Tsuchiya K, Nishio S, Hanaoka K, Tsuruya K, Ishimura E, Kamura K, Narita I, Nutahara K, Horie S.
Organizer
The 14th Asian Pacific Congress of Nephrology
Place of Presentation
Tokyo
Year and Date
2014-05-14 – 2014-05-17
Related Report
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[Presentation] The compiling data at the time of enrollment in J-PKD registry.2013
Author(s)
Horie S, Muto S, Mochizuki T, Tsuchiya T, Nishio S, Hanaoka K, Tsuruya K, Ishimura E, Narita I, Kamura K, Ubara Y, Nutahara K
Organizer
World Congress of Nephrology 2013
Place of Presentation
Hong Kong, China
Related Report
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[Presentation] The compiling data at the time of enrollment in J-PKD registry2013
Author(s)
Muto S, Mochizuki T, Tsuchiya K, Nishio S, Hanaoka K, Tsuruya K, Ishimura E, Narita I, Kamura K, Ubara Y, Ando M, Nutahara K, Horie S
Organizer
46th Annual Meeting of the American Society of Nephrology
Place of Presentation
Atlanta, USA
Related Report
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