• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of hormonal therapy for male infertility

Research Project

Project/Area Number 24592447
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionYamaguchi University

Principal Investigator

SHIRAISHI Koji  山口大学, 医学部附属病院, 講師 (00535255)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords無精子症 / 内分泌療法 / アンドロゲンレセプター / 精子形成 / テストステロン / ライディッヒ細胞
Outline of Final Research Achievements

In patients with non-obstructive azoospermia (NOA), salvage hormonal therapy increased intratesticular testosterone (ITT) level, resluting the restration of spermiogenesis. However, an appropriate concentration of ITT for spermatogenesis remains still unknown. Elevation of ITT also caused the increased expression of androgen receptor in Setoli cells. This elevation was promoted by the administration of recombinant human FSH.
Based on these results, we are establishing a new protocol, mainly by using recombinant human FSH, to stimulate the spermatogenesis in NOA men.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Microdissection testicular sperm extraction and salvage hormonal treatment in patients with postchemotherapy azoospermia.2014

    • Author(s)
      Shiraishi K, Matsuyama H
    • Journal Title

      Urology

      Volume: 83 Issue: 1 Pages: 100-106

    • DOI

      10.1016/j.urology.2013.08.043

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of testicular androgen receptor in non-obstructive azoospermia and its change after hormonal therapy2014

    • Author(s)
      Kato Y, Shiraishi K, Matusyama H
    • Journal Title

      Andrology

      Volume: 2 Issue: 5 Pages: 381-385

    • DOI

      10.1111/j.2047-2927.2014.00240.x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of hormonal therapy on spermatogonial DNA synthesis in men with non-obstructive azoospermia2013

    • Author(s)
      Eriko Shinjo, Koji Shiraishi, Hideyasu Matsuyama
    • Journal Title

      Andrology

      Volume: 1 Issue: 6 Pages: 929-935

    • DOI

      10.1111/j.2047-2927.2013.00141.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TESE時代における内分泌療法の復権2012

    • Author(s)
      白石晃司、松山豪泰
    • Journal Title

      泌尿器科外科

      Volume: 25 Pages: 989-991

    • Related Report
      2012 Research-status Report
  • [Presentation] 非閉塞性無精子症における精巣内アンドロゲンレセプターの発現と内分泌療法による変化2014

    • Author(s)
      白石晃司
    • Organizer
      日本アンドロロジー学会第33回学術大会
    • Place of Presentation
      軽井沢プリンスホテルウェスト(長野県、軽井沢町)
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effect of hormonal therapy on intratesticular testosterone level, androgen receptor expression and spermatogonial DNA synthesis in men with non-obstructive azoospermia2014

    • Author(s)
      白石晃司
    • Organizer
      American Urological Association 2014
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2014-05-18 – 2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非閉塞性無精子症に対するsalvage内分泌療法による精巣内テストステロン、精粗細胞におけるDNA合成およびアポトーシスの関連2013

    • Author(s)
      白石晃司
    • Organizer
      日本アンドロロジー学会第32回学術大会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Related Report
      2013 Research-status Report
  • [Presentation] Male Reproductive Microsurgery: Sperm Extraction2013

    • Author(s)
      Koji Shiraishi
    • Organizer
      第33回国際泌尿器科学会
    • Place of Presentation
      バンクーバー(カナダ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Human chorionic gonadotropin-based hormonal therapy in men after failed microdissection testicular sperm extraction.2013

    • Author(s)
      Koji Shiraishi, Hideyasu Matsuyama
    • Organizer
      10th International Congress of Andrology
    • Place of Presentation
      Melbourne (Australia)
    • Related Report
      2012 Research-status Report
  • [Presentation] Human chorionic gonadotropin-based hormonal therapy in men after failed microdissection testicular sperm extraction2012

    • Author(s)
      Koji Shiraishi, Hideyasu Matsuyama
    • Organizer
      32nd Congress of the Societe Internationale d’Urologie
    • Place of Presentation
      Fukuoka(福岡国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] 非閉塞性無精子症に対する内分泌療法~効く症例と効かない症例~2012

    • Author(s)
      白石晃司、松山豪泰
    • Organizer
      第57回日本生殖医学会学術講演会
    • Place of Presentation
      長崎市(長崎ブリックホール)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi