Establishment of hormonal therapy for male infertility
| Project/Area Number |
24592447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SHIRAISHI Koji 山口大学, 医学部附属病院, 講師 (00535255)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 無精子症 / 内分泌療法 / アンドロゲンレセプター / 精子形成 / テストステロン / ライディッヒ細胞 |
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| Outline of Final Research Achievements |
In patients with non-obstructive azoospermia (NOA), salvage hormonal therapy increased intratesticular testosterone (ITT) level, resluting the restration of spermiogenesis. However, an appropriate concentration of ITT for spermatogenesis remains still unknown. Elevation of ITT also caused the increased expression of androgen receptor in Setoli cells. This elevation was promoted by the administration of recombinant human FSH.
Based on these results, we are establishing a new protocol, mainly by using recombinant human FSH, to stimulate the spermatogenesis in NOA men.
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Report
(4 results)
Research Products
(11 results)
