| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In patients with non-obstructive azoospermia (NOA), salvage hormonal therapy increased intratesticular testosterone (ITT) level, resluting the restration of spermiogenesis. However, an appropriate concentration of ITT for spermatogenesis remains still unknown. Elevation of ITT also caused the increased expression of androgen receptor in Setoli cells. This elevation was promoted by the administration of recombinant human FSH.
Based on these results, we are establishing a new protocol, mainly by using recombinant human FSH, to stimulate the spermatogenesis in NOA men.
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