Functions of immune cells for achievement and maintenance of pregnancy
Project/Area Number |
24592456
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Hyogo Medical University (2016) Hirosaki University (2012-2015) |
Principal Investigator |
Fukui Atsushi 兵庫医科大学, 医学部, 講師 (00321969)
|
Project Period (FY) |
2012-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 生殖医学 / NK細胞 / NCR / サイトカイン / NK22 / NKp46 / 不育症 / 不妊症 / NK22細胞 / IFN-γ / TNF-α / 妊娠高血圧症候群 / 妊娠糖尿病 / 精液 / NCR22 / IFN-g / TNF-a / 精漿 / IL-22 / IL-23 |
Outline of Final Research Achievements |
I evaluated the function of NK cells for achievement and maintenance of pregnancy using pregnant or non-pregnant peripheral blood NK cells, and non-pregnant endometrial or aborted decidual NK cells. The abnormal expression of natural cytotoxicity receptors (NCRs), especially NKp46 on NK cell and the abnormal cytokines production by NK cells are associated with reproductive failures such as recurrent pregnancy loss, infertility and gestational diabetes mellitus. Cytokines production by NK cells may be regulated by NK22 cells. Interestingly, NK cells could be stimulated by partner’s lymphocytes or semen.
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Report
(6 results)
Research Products
(53 results)
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[Journal Article] 1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses.2015
Author(s)
Ota K, Dambaeva S, Kim MW, Han AR, Fukui A, Gilman-Sachs A, Beaman K, Kwak-Kim J
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Journal Title
Eur J Immunol
Volume: 45巻
Issue: 11
Pages: 3188-3199
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis2015
Author(s)
Atsushi Fukui, Mai Kamoi, Ayano Funamizu, Kohei Fuchinoue, Hitomi Chiba, Megumi Yokota, Rie Fukuhara, Hideki Mizunuma
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Journal Title
Reproductive Medicine and Biology
Volume: 印刷中
Related Report
Peer Reviewed
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