• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The research on how intrauterine inflammation transmit to fetus by the intermediary of fetal skin with using ovine model.

Research Project

Project/Area Number 24592458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

SAITO Masatoshi  東北大学, 大学病院, 助教 (00451584)

Co-Investigator(Kenkyū-buntansha) MATSUDA Tadashi  東北大学, 大学病院, 准教授 (50361100)
SUGAWARA Junichi  東北大学, 東北メディカル・メガバンク機構, 教授 (60280880)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords早産 / 子宮内感染 / 子宮内炎症 / 胎児皮膚組織 / 炎症性サイトカイン / Polymyxin B / 妊娠ヒツジ / ポリミキシンB
Outline of Final Research Achievements

Intrauterine infection is a leading cause of preterm birth, most notably in deliveries occurring before 32 weeks gestation. However, the details of the mechanism and pathway from intrauterine infection to fetal inflammation are still unknown. We made an intrauterine inflammation model with using pregnant sheep, and also could indicate that a cationic peptide antibiotic, Polymyxin B have a possibility to calm the intrauterine inflammation down causing with Escherichia coli lipopolysaccharides (LPS) in fetal skin tissue with decreasing of the expression of messenger RNA of inflammatory cytokines such as IL-1 beta, TNF-alpha, IL-6, IL-8 and MCP-2.
These data are consistent with a partial resolution of LPS-driven intrauterine inflammation. They suggest the potential for agonist capture as a conceptual means of resolving the pro-parturition inflammation caused by infection of the amniotic cavity.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Polymyxin B agonist capture therapy for intrauterine inflammation: proof-of-principle in a fetal ovine model.2014

    • Author(s)
      Saito M, Payne MS, Miura Y, Ireland DJ, Stock S, Kallapur SG, Kannan PS, Newnham JP, Kramer BW, Jobe AH, Keelan JA, Kemp MW.
    • Journal Title

      Reproductive Science

      Volume: 21(5) Issue: 5 Pages: 623-631

    • DOI

      10.1177/1933719113508820

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi