| Project/Area Number |
24592463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Shigeru 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 切迫早産 / 子宮収縮抑制剤 / 子宮内炎症 / 組織学的絨毛膜羊膜炎 / 子宮内感染 / 産科学 / 絨毛膜羊膜炎 / 新生児予後 |
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| Outline of Final Research Achievements |
The plognosis after treatment for preterm labor were classified into three groups, preterm birth(Group A), delivery within 2 days just after maintenance tocolysis(Group B), no delivery and waiting at home(Group C). In group A, it was important that there was severe inflammation and infection(38% positive, using highly sensitive PCR) in the amnion. And it was firstly reported that the amniotic inflammation (the values of IL-8 in the amniotic fluid) was able to predict the degree of histological chorioamnionitis(stage I or higher >9.9 ng/mL, stage II or higher >17.3 ng/mL and stage III >55.9 ng/mL, respectively).
The differency between Group B and C was slight amniotic inflammation at hospitalization. Group C(amniotic IL-8 <2.6 ng/mL) was able to be considered that the maintenance tocolysis would end from earlier stage of treatment.The knowledge correlated between the delivery just after end of maintenance tocolysis and slihgt amniotic inflammation was for the first time.
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