| Project/Area Number |
24592467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Naohiro 浜松医科大学, 医学部, 教授 (70204550)
ITO Hiroaki 浜松医科大学, 医学部附属病院, 教授 (70263085)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 亜鉛 / 鉄 / 胎児 / 貧血 / 人工羊水 / 抗炎症作用 / 胎盤通過性 / 微量元素 / 胎児発育 / 銅 |
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| Outline of Final Research Achievements |
The supplementation of zinc + iron significantly increased the hemoglobin compared to the iron alone for anemia pregnant women in the second trimester. The fetus growth did not show significant difference, but accepted fetal growth in zinc + iron group using a Z score. The umbilical cord blood zinc level was significantly higher than the maternal zinc level. Meconium stained amniotic fluid contained the higher level of zinc and iron. The level of copper was high and zinc was low in the maternal blood. The level of copper was low and zinc was high in the umbilical cord blood. We suggest a possible presence of selective trace elements transfer system in human placenta. Zinc might make the fetal environments better in amniotic fluid, fetal blood, and maternal blood.
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