Study of the efficacy of the replacement therapy of zinc in pregnant women and the fetal environment
Project/Area Number |
24592467
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Naohiro 浜松医科大学, 医学部, 教授 (70204550)
ITO Hiroaki 浜松医科大学, 医学部附属病院, 教授 (70263085)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 亜鉛 / 鉄 / 胎児 / 貧血 / 人工羊水 / 抗炎症作用 / 胎盤通過性 / 微量元素 / 胎児発育 / 銅 |
Outline of Final Research Achievements |
The supplementation of zinc + iron significantly increased the hemoglobin compared to the iron alone for anemia pregnant women in the second trimester. The fetus growth did not show significant difference, but accepted fetal growth in zinc + iron group using a Z score. The umbilical cord blood zinc level was significantly higher than the maternal zinc level. Meconium stained amniotic fluid contained the higher level of zinc and iron. The level of copper was high and zinc was low in the maternal blood. The level of copper was low and zinc was high in the umbilical cord blood. We suggest a possible presence of selective trace elements transfer system in human placenta. Zinc might make the fetal environments better in amniotic fluid, fetal blood, and maternal blood.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress2015
Author(s)
Muramatsu-Kato K, Itoh H, Kohmura-Kobayashi Y, Ferdous UJ, Tamura N, Yaguchi C, Uchida T, Suzuki K, Hashimoto K, Suganami T, Ogawa Y, Kanayama N
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 16867-16867
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Morphological characteristics of the placental basal plate in IVF pregnancies: a possible association with the amount of bleeding in delivery2015
Author(s)
Yuki Nakamura,Chizuko yaguchi,Hiroaki Itoh Ryoko Sakamoto,Takako Kimura,Naomi Furuta,Toshiyuki Uchida,Naoaki Tamura,Kazunao Suzuki,Kazuhiro Sumimoto,Yumiko Matsuda,Toshiki Matsura,Mitsura Nishimura,Naohiro Kanayama
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Journal Title
Human Pathology
Volume: inprint
Issue: 8
Pages: 1171-1179
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions2015
Author(s)
Farhana M, Tamura N, Mukai M, Ikuma K, Koumura Y, Furuta N, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Itoh H, Kanayama N
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Journal Title
J Reprod Immunol
Volume: 110
Pages: 74-80
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero2013
Author(s)
Y.K. Kohmura, N. Kanayama, K. Muramatsu, N. Tamura, C. Yaguchi, T. Uchida, K. Suzuki, K. Sugihara, S. Aoe, T. Sasaki, T. Suganami, Y. Ogawa, H. Itoh
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Journal Title
Reprod. Sci.
Volume: 20
Issue: 7
Pages: 813-827
DOI
Related Report
Peer Reviewed
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[Presentation] 非アルコール性脂肪性肝疾患(NAFLD)発症リスクにおける胎生期低栄養環境の関わり2015
Author(s)
村松 慧子, 幸村 友季子, 山崎 香織, 伊熊 ことみ, 向 麻利, 田村 直顕, 内田 季之, 谷口 千津子, 鈴木 一有, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
第51回日本周産期・新生児医学会
Place of Presentation
福岡県福岡市
Year and Date
2015-07-10
Related Report
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[Presentation] 妊娠中のエネルギー摂取不足と成長後の児の非アルコール性脂肪性肝疾患(NAFLD)発症リスク2015
Author(s)
村松 慧子, 幸村 友季子, 松本 雅子, 山崎 香織, 伊熊 ことみ, 古田 直美, 内田 季之, 谷口 千津子, 鈴木 一有, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
第67回日本産科婦人科学会学術講演会
Place of Presentation
神奈川県横浜市
Year and Date
2015-04-12
Related Report
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[Presentation] 新規に開発した内診指接着型胎児オキシメーターによる分娩II期の胎児酸素動態2015
Author(s)
内田 季之, 東堂 祐介, 鈴木 崇公, 上田 めぐみ, 柏木 唯衣, 向 麻利, 幸村 友季子, 古田 直美, 鈴木 一有, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
第67回日本産科婦人科学会学術講演会
Place of Presentation
神奈川県横浜市
Year and Date
2015-04-12
Related Report
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[Presentation] 妊婦の代謝異常 胎生期低栄養環境に引き続く出生後の著しいcatch-up growthが成長後のメタボリックシンドロームの発症リスクに及ぼす影響 小胞体ストレスとの関わり2015
Author(s)
幸村 友季子, 村松 慧子, 山崎 香織, 伊熊 ことみ, 向 麻利, 古田 直美, 田村 直顕, 内田 季之, 鈴木 一有, 杉原 一廣, 伊東 宏晃, 金山 尚裕
Organizer
第67回日本産科婦人科学会学術講演会
Place of Presentation
神奈川県横浜市
Year and Date
2015-04-10
Related Report
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