| Project/Area Number |
24592468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
IWASE Akira 名古屋大学, 医学部附属病院, 病院教授 (20362246)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Maki 名古屋大学, 医学部附属病院, 病院講師 (90378125)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Tomoko 名古屋大学, 医学部附属病院, 病院助教 (40732681)
NAKAHARA Tatsuo 名古屋大学, 医学部附属病院, 助教 (50534830)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 卵胞発育 / 顆粒膜細胞 / 脂質メディエーター / コレステロール合成 / S1P / GDF-9 / スフィンゴシン1リン酸 / コレステロール / FF-MAS |
|---|
| Outline of Final Research Achievements |
An oocyte-derived growth factor, growth differentiation factor-9 upregulated the cholesterol-synthetic enzymes in human granulosa cells. We found the significant differences in the expression of the cholesterol-synthetic enzymes between luteinized granulosa cells derived from pregnant and non-pregnant follicles.
A lysophospholipid mediator, shingosine-1-phosphate (S1P) activated the PI3K-Akt pathway and stimulated proliferation of human granulosa cells. In addition, S1P inhibited H2O2-induced apoptosis of granulosa cells.
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