| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Aberrant DNA hypomethylation in the whole X chromosome occurs in the uterine leiomyoma. In this study, we verified whether the aberrant expression of aberrantly hypomethylated genes specific to the leiomyoma or the dysfunction of genes related to the X chromosome inactivation (XCI) might be involved in the development of leiomyoma. As a result, although the two aberrantly hypomethylated genes specific to the leiomyoma on the X chromosome were identified, the aberrant expression did not occur in these genes. The expression analysis of XCI-related genes revealed that the expression of XIST and SATB1 genes tended to be altered similarly and was downregulated simultaneously in about a half of leiomyoma specimens. Therefore, the aberration of XCI-related genes such as SATB1 or XIST may be involved in aberrant hypomethylation on the X chromosome in a certain population of the patients with uterine leiomyomas.
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