Therapeutic approach using activation of the cholinergic response via acetylcholine receptor on tissue damage after HI in the developing brain.
| Project/Area Number |
24592477
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 周産期脳障害 / 低酸素虚血 / ラット / 迷走神経 / 炎症 / 治療 |
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| Outline of Final Research Achievements |
The efficacy of cholinergic stimulation for hypoxic-ischemic brain damage was evaluated in newborn rats. Cholinergic stimulation showed a marked reduction of brain damage, on the other hand, cholinergic inhibition showed a marked exacerbation. Regional specificity was observed for both microglial activation and susceptibility to cholinergic stimulation after hypoxia-ischemia. IL-1β production was also noted on hypoxic-ischemic brain. Regional microglial activation and IL-1β production was significantly reduced with timely cholinergic stimulation. Thus, we demonstrated that cholinergic stimulation reduced brain damage with a suppressive effect on microglial activation and IL-1 in a newborn rat model of hypoxia-ischemia. Under hypoxic-ischemic environments, activation of the cholinergic inflammatory response is effective against perinatal brain damage.
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Report
(4 results)
Research Products
(7 results)
