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Genetic causes of recurrent pregnancy loss

Research Project

Project/Area Number 24592478
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNagoya City University

Principal Investigator

Sugiura Mayumi  名古屋市立大学, 医学(系)研究科(研究院), 教授 (30264740)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords不育症 / 習慣流産 / 凝固第XII因子 / 凝固第V因子 / プロテインS / ループスアンチコアグラント / 抗リン脂質抗体 / 不育症易罹患性遺伝子 / Recurrent Pregnancy Loss / Recurrent Miscarriage / Coagulation Factor XII / Annexin A5 / Protein S / Coagulation Factor V / APS / PGD / recurrent pregnancy loss / recurrent miscarriege / Factor XII / Factor V Nara / R2 haplotype / PGD / recurrent miscarriage
Outline of Final Research Achievements

Six kinds of SNPs of ANXA5, CT genotype of coagulation factor XII (FXII) and GT and TT genotype of Ser156Ser of FV were found to be risk factors for recurrent pregnancy loss (RPL). The frequency of protein S (PS) Tokushima in patients was similar to that in controls. No case of Nara mutation and Hong Kong mutation were found in both patients and controls. There was no difference of subsequent live birth rate between with and without risk alleles of ANXA5, FXII, FV and PS Tokushima. There was no difference of subsequent live birth rate between low and normal levels of FXII activity, PS antigen, PS activity and PS specific activity after excluding cases with RPL caused by abnormal embryonic karyotype.
We found CT genotype of FXII as a risk factor for RPL at the first time. However, the genotyping of these risk alleles and testing for FXII activity and PS measurement were not necessary because of absence of clinical benefit.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (98 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 20 results,  Acknowledgement Compliant: 3 results,  Open Access: 4 results) Presentation (72 results) (of which Int'l Joint Research: 14 results,  Invited: 28 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] Phadia(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with recurrent miscarriag2016

    • Author(s)
      Yuki Obayashi, Yasuhiko Ozaki, Satomi Kurakane, Shinobu Goto, Kyoko Kumagai, Tamao Kitaori, Suzumori Nobuhiro, Mayumi Sugiura
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 75 Issue: 1 Pages: 69-77

    • DOI

      10.1111/aji.12434

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conservative therapy with a gonadotropin-releasing hormone agonist for a uterine arteriovenous malformation in a patient with congenital heart disease.2015

    • Author(s)
      Katano K, Takeda Y, Sugiura-Ogasawara M.
    • Journal Title

      Clin Case Rep.

      Volume: 3 Issue: 6 Pages: 479-482

    • DOI

      10.1002/ccr3.233

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of clinically significant tests for antiphospholipid antibodies and cutoff levels for obstetric antiphospholipid syndrome.2015

    • Author(s)
      Kitaori T, Sugiura-Ogasawara M, Oku K, Papisch W, Ebara T, Ozaki Y, Katano K, Atsumi T.
    • Journal Title

      Lupus

      Volume: 24 Issue: 14 Pages: 1505-1519

    • DOI

      10.1177/0961203315595128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Preimplantation Genetic Diagnosis and Natural Conception: A Comparison of Live Birth Rates in Patients with Recurrent Pregnancy Loss Associated with Translocation.2015

    • Author(s)
      Ikuma S, Sato T, Sugiura-Ogasawara M, Nagayoshi M, Tanaka A, Takeda S.
    • Journal Title

      PlosOne

      Volume: 17 Issue: 6 Pages: 1-12

    • DOI

      10.1371/journal.pone.0129958

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and molecular findings in a patient with 46,XX/47,XX,+14 mosaicism caused by postzygotic duplication of a paternally derived chromosome 14.2015

    • Author(s)
      Suzumori N, Kagami M, Kumagai K, Goto S, Matsubara K, Sano S, Sugiura-Ogasawara M.
    • Journal Title

      Am J Med Genet A

      Volume: 167(10) Issue: 10 Pages: 2474-7

    • DOI

      10.1002/ajmg.a.37194

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary prophylaxis to prevent obstetric complications in asymptomatic women with antiphospholipid antibodies: a systematic review.2015

    • Author(s)
      Amengual O, Fujita D, Ota E, Carmona L, Oku K, Sugiura-Ogasawara M, Murashima A, Atsumi T.
    • Journal Title

      Lupus

      Volume: 24 Issue: 11 Pages: 1135-1142

    • DOI

      10.1177/0961203315578765

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Real-world practice of obstetricians in respect of assays for antiphospholipid antibodies.2015

    • Author(s)
      Sugiura-Ogasawara M, Atsumi T, Yamada H, Kitaori H, Ozaki Y, Katano K, Murashima A.
    • Journal Title

      Modern Rheumatology

      Volume: 30 Issue: 6 Pages: 1-22

    • DOI

      10.3109/14397595.2015.1023978

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prenatal findings of holoprosencephaly.2015

    • Author(s)
      Hayashi Y, Suzumori N, Sugiura T, Sugiura-Ogasawara M
    • Journal Title

      Congenit Anom

      Volume: 55 Issue: 3 Pages: 161-163

    • DOI

      10.1111/cga.12103

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parental decisions following prenatal diagnosis of chromosomal abnormalities: implications for genetic counseling practice in Japan2015

    • Author(s)
      Suzumori N, Kumagai K, Goto S, Nakamura A, Sugiura-Ogasawara M
    • Journal Title

      J Genet Couns

      Volume: 24 Issue: 1 Pages: 117-121

    • DOI

      10.1007/s10897-014-9744-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-world practice of obstetricians in respect of assays for antiphospholipid antibodies.2015

    • Author(s)
      Sugiura-Ogasawara M, Atsumi T, Yamada H, Kitaori H, Ozaki Y, Katano K, Murashima A.
    • Journal Title

      Mod Rheumatol

      Volume: Apr 30 Pages: 1-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies?2015

    • Author(s)
      Sugiura-Ogasawara M, Lin B-L, Aoki K, Maruyama T, Nakatsuka M, Ozawa N, Sugi T, Takeshita T, Nishida M
    • Journal Title

      J Obstet Gynaecol.

      Volume: 35 Issue: 2 Pages: 155-158

    • DOI

      10.3109/01443615.2014.936839

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genotyping Analysis for the 46 C/T Polymorphism of Coagulation Factor XII and the Involvement of Factor XII Activity in Patients with Recurrent Pregnancy Loss.2014

    • Author(s)
      Asano E, Ebara T, Yamada-Namikawa C, Kitaori T, Suzumori N, Katano K, Ozaki Y, Nakanishi M, Sugiura-Ogasawara M.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 12 Pages: e114452-e114452

    • DOI

      10.1371/journal.pone.0114452

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-specific psychological distress in women undergoing noninvasive prenatal testing because of advanced maternal age.2014

    • Author(s)
      Suzumori N, Ebara T, Kumagai K, Goto S, Yamada Y, Kamijima M, Sugiura-Ogasawara M.
    • Journal Title

      Prenat Diagn

      Volume: 34 Issue: 11 Pages: 1055-1060

    • DOI

      10.1002/pd.4427

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage.2014

    • Author(s)
      Goto S, Ozaki Y, Suzumori N, Yasukochi A, Kawakubo T, Furuno T, Nakanishi M, Yamamoto K, Sugiura-Ogasawara M.
    • Journal Title

      Mol Hum Reprod.

      Volume: 20 Issue: 5 Pages: 454-462

    • DOI

      10.1093/molehr/gau008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage2014

    • Author(s)
      Goto S, Ozaki Y, Suzumori N, Yasukochi A, Kawakubo T, Furuno T, Nakanishi M, Yamamoto K, Sugiura-Ogasawara M
    • Journal Title

      Mol Hum Reprod

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss.2013

    • Author(s)
      Hayashi Y, Sasaki H, Suzuki S, Nishiyama T, Kitaori T, Mizutani E , Suzumori N, Sugiura-Ogasawara M.
    • Journal Title

      Fertility and Sterility

      Volume: 100 Issue: 4 Pages: 1018-1024

    • DOI

      10.1016/j.fertnstert.2013.06.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: The Okazaki Cohort Study in Japan.2013

    • Author(s)
      Sugiura-Ogasawara M, Suzuki S, Ozaki Y, Katano K, Suzumori N, Kitaori T.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 39 Issue: 1 Pages: 126-131

    • DOI

      10.1111/j.1447-0756.2012.01973.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible improvement of depression after systematic examination and explanation of live birth rates among women with recurrent miscarriage.2013

    • Author(s)
      Sugiura-Ogasawara M, Nakano Y, Ozaki Y, Furukawa TA.
    • Journal Title

      J Obstet Gynecol

      Volume: 33 Issue: 2 Pages: 171-174

    • DOI

      10.3109/01443615.2012.745490

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cognitive behavior therapy for psychological distress in patients with recurrent miscarriage.2013

    • Author(s)
      Nakano Y, Akechi T, Furukawa T, Sugiura-Ogasawara M.
    • Journal Title

      Psychology Research and Behavior Management

      Volume: 6 Pages: 37-43

    • DOI

      10.2147/prbm.s44327

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss: a large cohort study.2013

    • Author(s)
      Katano K, Suzuki S, Ozaki Y, Suzumori N, Kitaori T, Sugiura-Ogasawara M.
    • Journal Title

      Fertility and Sterility

      Volume: 100 Issue: 6 Pages: 1629-1634

    • DOI

      10.1016/j.fertnstert.2013.07.1996

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Müllerian anomalies and recurrent miscarriage.2013

    • Author(s)
      Sugiura-Ogasawara M, Ozaki Y, Suzumori N.
    • Journal Title

      Current Opinion in Obstetrics and Gynecology

      Volume: 25 Issue: 4 Pages: 293-298

    • DOI

      10.1097/gco.0b013e3283632849

    • Related Report
      2013 Research-status Report
  • [Presentation] Candidate genes associated with recurrent pregnancy loss2016

    • Author(s)
      Sugiura-Ogasawara M
    • Organizer
      The 13th International Congress of Human genetics
    • Place of Presentation
      Kyoto I ternational Conference
    • Year and Date
      2016-04-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preimplantation genetic diagnosis and natural conception: A comparison of live birth rates in patients with recurrent pregnancy loss associated with translocation.2016

    • Author(s)
      Ikuma S, Sato T, Sugiura-Ogasawara M, Yamaguchi T, Miki T, Nagayoshi M, Tanaka A, Takeda S.
    • Organizer
      The 13th International Congress of Human genetics
    • Place of Presentation
      Kyoto I ternational Conference
    • Year and Date
      2016-04-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical and molecular findings in a patient with 46,XX/47,XX,+14 mosaicism caused by postzygotic duplication of a paternally derived chromosome 14.2016

    • Author(s)
      Suzumori N, Kagami M, Kumagai K, Goto S, Matsubara K, Sano S, Sugiura-Ogasawara M.
    • Organizer
      The 13th International Congress of Human genetics
    • Place of Presentation
      Kyoto I ternational Conference
    • Year and Date
      2016-04-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Backgroud of couples undergoing non-invasive prenatal testing in Japan.2016

    • Author(s)
      Takeda E, Suzumori N, Kagami K, Oseto K, Ebara T, Yotsumoto J, Numabe H, Sugiura-Ogasawara M.
    • Organizer
      The 13th International Congress of Human genetics
    • Place of Presentation
      Kyoto I ternational Conference
    • Year and Date
      2016-04-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Keynote Lecture: Candidate genes associated with recurrent pregnancy loss.2016

    • Author(s)
      Sugiura-Ogasawara M, Kitaori T, Katano K, Ozaki Y
    • Organizer
      1st World Congress on Recurrent Pregnancy Loss.
    • Place of Presentation
      Cannes (France)
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Protease and inhibitor in pathogenesis of recurrent pregnancy loss-Role of calpain-calpastatin system in recurrent pregnancy loss.2016

    • Author(s)
      Ozaki Y, SugiuraOgasawara M.
    • Organizer
      1st World Congress on Recurrent Pregnancy Loss.
    • Place of Presentation
      Cannes (France)
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Real-world practice of obstetricians in respect of assays for antiphospholipid antibodies.2016

    • Author(s)
      Matsumoto Y, Sugiura-Ogasawara M, Atsumi T, Yamada H, Kitaori T, Ozaki Y, Katano K, Murashima A.
    • Organizer
      1st World Congress on Recurrent Pregnancy Loss.
    • Place of Presentation
      Cannes (France)
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preimplantation genetic diagnosis and natural conception: A comparison of live birth rates in patients with recurrent pregnancy loss associated with translocation.2016

    • Author(s)
      Ikuma S, Sato T, Sugiura-Ogasawara M, Nagayoshi M, Tanaka A, Takeda S.
    • Organizer
      1st World Congress on Recurrent Pregnancy Loss.
    • Place of Presentation
      Cannes (France)
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 無侵襲的出生前遺伝学的検査を受検したクライアントの背景に関する検討2015

    • Author(s)
      武田恵利、鈴森伸宏、熊谷恭子、後藤志信、大林勇樹、大瀬戸久美子、榎原毅、四元淳子、沼部博直、杉浦真弓
    • Organizer
      第1回日本産科婦人科遺伝診療学会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗リン脂質抗体症候群女性の妊娠中の管理状況に関する多施設症例調査2015

    • Author(s)
      出口雅士、山田秀人、藤田太輔、杉浦真弓、森川守、三木明徳、牧野真太郎、村島温子
    • Organizer
      第30回日本生殖免疫学会
    • Place of Presentation
      くまもと県民交流館パレア(熊本県)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗リン脂質抗体測定法に関する全国調査2015

    • Author(s)
      松本洋介、北折珠央、山田秀人、片野衣江、尾崎康彦、杉浦真弓、村島温子、渥美達也
    • Organizer
      第30回日本生殖免疫学会
    • Place of Presentation
      くまもと県民交流館パレア(熊本県)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 反復流産病態における妊娠初期頸管粘液中のIL-33とcathepsin Gの関与2015

    • Author(s)
      後藤志信、尾崎康彦、大林勇樹、倉兼さとみ、杉浦真弓
    • Organizer
      第30回日本生殖免疫学会
    • Place of Presentation
      くまもと県民交流館パレア(熊本県)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子標的治療薬のアニュアルエビデンスレビュー:産科抗リン脂質抗体症候群2015

    • Author(s)
      杉浦真弓
    • Organizer
      第43回日本臨床免疫学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 着床前診断と生殖医療の倫理的諸問題2015

    • Author(s)
      杉浦真弓
    • Organizer
      第42回日本産婦人科医会学術集会
    • Place of Presentation
      新潟グランドホテル(新潟市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 抗リン脂質抗体測定法の標準化2015

    • Author(s)
      北折珠央、尾崎康彦、片野衣江、奥健志、渥美達也、杉浦真弓
    • Organizer
      第42回日本産婦人科医会学術集会
    • Place of Presentation
      新潟グランドホテル(新潟市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不育症電話相談窓口豆柴ダイヤルの報告2015

    • Author(s)
      三木有希、田中幸子、杉浦真弓
    • Organizer
      第56回日本母性衛生学
    • Place of Presentation
      盛岡市民文化ホール(岩手県)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 無侵襲性出生前遺伝学的検査(NIPT)を受検したクライアントの背景に関する検討2015

    • Author(s)
      武田恵利、鈴森伸宏、熊谷恭子、後藤志信、松本洋介、大林勇輝、大瀬戸久美子、榎原毅、沼部博直、杉浦真弓
    • Organizer
      第60回日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京、新宿区)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] NIPT受検妊婦におけるメンタルストレスと妊娠・周産期合併症との関連について2015

    • Author(s)
      熊谷恭子、鈴森伸宏、武田恵利、大瀬戸久美子、大林勇輝、松本洋介、後藤志信、杉浦真弓
    • Organizer
      第60回日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京、新宿区)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胚培養士の向上に資する着床前診断の知識2015

    • Author(s)
      杉浦真弓
    • Organizer
      日本卵子学会第7回生殖補助医療胚培養士セミナー
    • Place of Presentation
      東京TFTビル(東京、江東区)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不育症のエビデンス2015

    • Author(s)
      杉浦真弓
    • Organizer
      第10回四国ナノピア凝固・線溶研究会
    • Place of Presentation
      香川医科大学
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不育症と抗リン脂質抗体症候群2015

    • Author(s)
      杉浦真弓
    • Organizer
      第22回東海KOAG研究会
    • Place of Presentation
      キャッスルプラザ(名古屋市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 抗リン脂質抗体測定法に関する全国調査2015

    • Author(s)
      松本洋介、北折珠央、山田秀人、尾崎康彦、杉浦真弓、村島温子
    • Organizer
      第36回日本高血圧学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不育症のエビデンス2015

    • Author(s)
      杉浦真弓
    • Organizer
      第34回日本思春期学会
    • Place of Presentation
      ピアザ淡海(滋賀県)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不育症における抗リン脂質抗体症候群と凝固線溶系の関与2015

    • Author(s)
      杉浦真弓
    • Organizer
      第20回病態プロテアーゼ学会
    • Place of Presentation
      ANAクラウンプラザホテルグランコート(名古屋市)
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 日本産科婦人科学会着床前スクリーニング臨床研究2015

    • Author(s)
      杉浦真弓
    • Organizer
      杉浦真弓「日本産科婦人科学会着床前スクリーニング臨床研究」日本産科婦人科学会生殖医療に関する遺伝カウンセリング受け入れ可能な臨床遺伝専門医.
    • Place of Presentation
      東京カンファランスセンター品川
    • Year and Date
      2015-07-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Comparison of the live birth rate between preimplantation genetic diagnosis and natural conception in patients with recurrent pregnancy loss associated with translocation.2015

    • Author(s)
      Ikuma S, Sato T, Sugiura-Ogasawara M, Nagayoshi M, Tanaka A, Takeda S.
    • Organizer
      31th Annual meeting of ESHRE.
    • Place of Presentation
      Lisbon (portugal)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High and low factor V activity, but not Factor V Nara and Hong Kong mutations, might be associated with recurrent miscarriage.2015

    • Author(s)
      Izuhara M, Shinozawa K, Kitaori T, Katano K, Ozaki Y, Fukutake K, Sugiura-Ogasawara M.
    • Organizer
      31th Annual meeting of ESHRE.
    • Place of Presentation
      Lisbon (portugal)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genotyping analyses for polymorphisms of PD-1 gene and CTLA4 gene in patients with recurrent pregnancy loss.2015

    • Author(s)
      Hayashi Y, Matsukawa Y, Kitaori T, Katano K, Ozaki Y, Sugiura M.
    • Organizer
      31th Annual meeting of ESHRE.
    • Place of Presentation
      Lisbon (portugal)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 不育症における凝固第XII因子活性と46C/T遺伝子多型2015

    • Author(s)
      橋本恵理子、北折珠央、鈴森伸宏、片野衣江、松原寛和、尾崎康彦、杉浦真弓
    • Organizer
      第37回中部生殖医学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 反復流産病態におけるindoleamine 2,3-dioxygenaseおよびtriptophan 2,3-dioxygenaseの存在と意義2015

    • Author(s)
      大林勇輝、尾崎康彦、後藤志信、大林伸太郎、熊谷恭子、北折珠央、大山文男、乃祢重信、鈴森伸宏、杉浦真弓
    • Organizer
      第25回日本産婦人科・新生児血液学会
    • Place of Presentation
      JA共済カンファランスホール (東京、千代田区)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss.2015

    • Author(s)
      Asano E, Ebara E, Yamada-Namikawa C, Kitaori T, Suzumori N, Katano K, Ozaki Y, Sugiura-Ogasawara M.
    • Organizer
      Internationa Federation of Fertility Societies.
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-26 – 2015-04-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Time-Lapse monitoring of oocytes activated artificially with electrical stimulation following ICSI with immotile sperm retrieved by MD-TESE2015

    • Author(s)
      Sawada Y, Sato T, Saito C, Matsukawa Y, Izuhara M, Sugiura M, Iwatsuki S, Umemoto Y, Sasaki S.
    • Organizer
      Internationa Federation of Fertility Societies.
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-26 – 2015-04-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 着床前診断は生児獲得率改善に有効か?2015

    • Author(s)
      杉浦真弓
    • Organizer
      第60回日本生殖医学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-26 – 2015-04-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss.2015

    • Author(s)
      Asano E, Ebara E, Yamada-Namikawa C, Kitaori T, Suzumori N, Katano K, Ozaki Y, Sugiura-Ogasawara M.
    • Organizer
      International Federation of Fertility Societies.
    • Place of Presentation
      PACIFICO Yokohama
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Time-Lapse monitoring of oocytes activated artificially with electrical stimulation following ICSI with immotile sperm retrieved by MD-TESE.2015

    • Author(s)
      Sawada Y, Sato T, Saito C, Matsukawa Y, Izuhara M, Sugiura M, Iwatsuki S, Umemoto Y, Sasaki S.
    • Organizer
      International Federation of Fertility Societies.
    • Place of Presentation
      PACIFICO Yokohama
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Successful pregnancy after artificial insemination with washed sperm in a case of human seminal plasma allergy.2015

    • Author(s)
      Matsukawa Y, Sato T, Saito C, Sawada Y, Izuhara M, Sugiura M.
    • Organizer
      International Federation of Fertility Societies.
    • Place of Presentation
      PACIFICO Yokohama
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 着床前診断は生児獲得率改善に有効か?2015

    • Author(s)
      杉浦真弓
    • Organizer
      第60回日本生殖医学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不妊症・不育症で悩む貴女へ2015

    • Author(s)
      杉浦真弓
    • Organizer
      第29回日本医学会総会
    • Place of Presentation
      京都大学
    • Year and Date
      2015-04-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不妊症・不育症で悩む貴女へ2015

    • Author(s)
      杉浦真弓
    • Organizer
      第29回日本医学会総会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2015-04-11 – 2015-04-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 抗リン脂質抗体測定法に関する全国調査2015

    • Author(s)
      北折珠央、山田秀人、片野衣江、尾崎康彦、杉浦真弓、村島温子
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 不育症における凝固第XII因子活性と46C/T遺伝子多型2015

    • Author(s)
      橋本恵理子、北折珠央、鈴森伸宏、片野衣江、尾崎康彦、杉浦真弓
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 不育症女性におけるPD-1,CTLA-4遺伝子多型についての検討2015

    • Author(s)
      林裕子、松川泰、北折珠央、片野衣江、尾崎康彦、杉浦真弓
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 着床前診断は均衡型転座に起因する反復流産患者の生児獲得率を改善するか?2015

    • Author(s)
      伊熊慎一郎、佐藤剛、杉浦真弓、吉永基、田中温、竹田省
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2015-04-09 – 2015-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 着床前診断は均衡型転座に起因する反復流産患者の生児獲得率を改善するか?2015

    • Author(s)
      伊熊慎一郎、佐藤剛、杉浦真弓、吉永基、田中温、竹田省
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不育症女性におけるPD-1,CTLA-4遺伝子多型についての検討2015

    • Author(s)
      林裕子、松川泰、北折珠央、片野衣江、尾崎康彦、杉浦真弓
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不育症における凝固第XII因子活性と46C/T遺伝子多型2015

    • Author(s)
      橋本恵理子、北折珠央、鈴森伸宏、片野衣江、尾崎康彦、杉浦真弓
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高齢妊婦におけるメンタルストレスとNIPTの遺伝カウンセリングについて2015

    • Author(s)
      鈴森伸宏、熊谷恭子、後藤志信、橋本恵理子、倉兼さとみ、大瀬戸久美子、杉浦真弓
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 無侵襲的出生前診断(NIPT)受検妊婦の背景及び経過についての検討2015

    • Author(s)
      熊谷恭子、鈴森伸宏、大瀬戸久美子、倉兼さとみ、橋本恵理子、後藤志信、杉浦真弓
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗リン脂質抗体測定法に関する全国調査2015

    • Author(s)
      北折珠央、山田秀人、片野衣江、尾崎康彦、杉浦真弓、村島温子
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不育症のエビデンス2015

    • Author(s)
      杉浦真弓
    • Organizer
      第11回愛知県産婦人科MEセミナー
    • Place of Presentation
      名古屋国際センターANNEXホール(愛知県)
    • Year and Date
      2015-02-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 不育症のエビデンス2015

    • Author(s)
      杉浦真弓
    • Organizer
      岐阜県医師会母体保護法指定医師研修会
    • Place of Presentation
      岐阜県医師会館(岐阜県)
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 最前線医療から~妊娠・出産・養育を支援する保健師へのメッセージ~2015

    • Author(s)
      杉浦真弓
    • Organizer
      愛知県市町村保健師協議会
    • Place of Presentation
      国保会館(愛知県)
    • Year and Date
      2015-01-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 不育症における凝固第XII因子活性と46C/T遺伝子多型2014

    • Author(s)
      橋本恵理子、榎原毅、山田千里、北折珠央、鈴森伸宏、片野衣江、尾崎康彦、杉浦真弓
    • Organizer
      第29回日本生殖免疫学会
    • Place of Presentation
      伊藤国際学術研究センター(東京都)
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 橋本恵理子、榎原毅、山田千里、北折珠央、鈴森伸宏、片野衣江、尾崎康彦、杉浦真弓2014

    • Author(s)
      橋本恵理子、榎原毅、山田千里、北折珠央、鈴森伸宏、片野衣江、尾崎康彦、杉浦真弓
    • Organizer
      第59回日本生殖医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 不育症における凝固第XII因子活性と46CT遺伝子多型2014

    • Author(s)
      橋本恵理子、榎原毅、山田-並河千里、北折珠央、鈴森伸宏、片野衣江、尾崎康彦、杉浦-小笠原真弓
    • Organizer
      第59回日本人類遺伝学会
    • Place of Presentation
      タワーホール船場(東京都)
    • Year and Date
      2014-11-19 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 産科抗リン脂質抗体症候群における測定法の標準化の試み2014

    • Author(s)
      北折珠央、奥健志、片野衣江、尾崎康彦、杉浦真弓、渥美達也
    • Organizer
      第42回日本臨床免疫学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of calpain in human placenta of patients with fetal growth restriction.2014

    • Author(s)
      Goto S, Ozaki Y, Kurakane S, Obayashi Y, Kumagai K, Kitaori T, Suzumori N, Sugiura-Ogasawara M.
    • Organizer
      The 46th International Congress on Pathophysiology of pregnancy
    • Place of Presentation
      京王プラザ(東京都)
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Determination of clinically significant tests for antiphospholipid antibodies and cutoff levels for obstetric antiphospholipid syndrome.2014

    • Author(s)
      Kitaori T, Izuhara M, Hashimoto E, Hayashi Y, Katano K, Ozaki Y, Sugiura-Ogasawara M.
    • Organizer
      The 46th International Congress on Pathophysiology of pregnancy.
    • Place of Presentation
      京王プラザ(東京都)
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 不育症の診断と治療2014

    • Author(s)
      杉浦真弓
    • Organizer
      長野県周産期医療研究会
    • Place of Presentation
      長野県立こども病院(長野県)
    • Year and Date
      2014-08-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss.2014

    • Author(s)
      Hashimoto E, Ebara E, Yamada-Namikawa C, Kitaori T, Suzumori N, Katano K, Ozaki Y, Sugiura-Ogasawara M.
    • Organizer
      30th Annual meeting of ESHRE
    • Place of Presentation
      Munich(ドイツ)
    • Year and Date
      2014-06-29 – 2014-07-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Determination of clinically significant tests for anti-phospholipid antibodies and cutoff levels for obstetric antiphospholipid syndrome.2014

    • Author(s)
      Kitaori T, Sugiura-Ogasawara M, Oku K, Papisch W, Ozaki Y, Atsumi T.
    • Organizer
      30th Annual meeting of ESHRE.
    • Place of Presentation
      Munich(ドイツ)
    • Year and Date
      2014-06-29 – 2014-07-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Trial for standardization of the measurement for antiphospholipid antibodies in recurrent pregnancy loss2013

    • Author(s)
      Sugiura-Ogasawara M, Kitaori T, Ozaki Y, Katano K, Atsumi T.
    • Organizer
      14th International congress on Antiphospholipid antibodies.
    • Place of Presentation
      ソフィテルリオデジャネイロコパカバーナ(Rio de Janeiro)
    • Related Report
      2013 Research-status Report
  • [Presentation] Genotyping analyses for polymorphisms of the ANXA5 gene in patients with recurrent pregnancy loss.2013

    • Author(s)
      Hayashi Yu, Mizutani E, Kitaori T, Katano K, Ozaki Y, Suzumori N.
    • Organizer
      29th Annual Meeting of the ESHRE
    • Place of Presentation
      ExCel Centre(London)
    • Related Report
      2013 Research-status Report
  • [Presentation] Synaptonemal complex protein 3 mutation is not necessarily associated with female infertility.2013

    • Author(s)
      Mizutani E, Suzumori N, Sugiyama C, Hattori Y, Sato T, Ando Y, Ozaki Y, Sugiura-Ogasawara M.
    • Organizer
      29th Annual Meeting of the ESHRE
    • Place of Presentation
      ExCel Centre(London)
    • Related Report
      2013 Research-status Report
  • [Presentation] 原因不明不育症における遺伝子の関与2013

    • Author(s)
      北折珠央、林裕子、水谷栄太、尾崎康彦、鈴森伸宏、杉浦真弓
    • Organizer
      第58回日本生殖医学会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 不育症における抗リン脂質抗体標準化に関する研究

    • Author(s)
      北折珠央、杉浦真弓
    • Organizer
      成育疾患克服等次世代育成基盤研究事業講演会
    • Place of Presentation
      日本子ども家庭総合研究所(東京)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 着床前診断の現状と問題点

    • Author(s)
      杉浦真弓
    • Organizer
      第35回石川県周産期・新生児研究会
    • Place of Presentation
      石川県中央病院(金沢)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 着床前診断の現状と問題点

    • Author(s)
      杉浦真弓
    • Organizer
      日本産科婦人科学会倫理委員会「着床前受精卵遺伝子スクリーニングを考える」公開シンポジウム
    • Place of Presentation
      都市センターホテル(東京)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 不育症の検査と治療

    • Author(s)
      杉浦真弓
    • Organizer
      第45回日本臨床検査自動化学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 不育症の検査と治療

    • Author(s)
      杉浦真弓
    • Organizer
      第50回関甲信支部医学検査学会
    • Place of Presentation
      つくば国際会議場(つくば)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 不育症

    • Author(s)
      杉浦真弓
    • Organizer
      第135回東北連合産科婦人科学会
    • Place of Presentation
      山形テルサ(山形)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 抗リン脂質抗体症候群と不育症

    • Author(s)
      杉浦真弓
    • Organizer
      第35回日本血栓止血血液学会
    • Place of Presentation
      山形国際ホテル(山形)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Recurrent pregnancy loss2016

    • Author(s)
      Sugiura-Ogasawara M, Ozaki Y, Katano K, Kitaori T
    • Total Pages
      300
    • Publisher
      Springer International Publishing
    • Related Report
      2015 Annual Research Report
  • [Book] Precision Medicine in Gynecology and Obstetrics2016

    • Author(s)
      Sugiura-Ogasawara M
    • Publisher
      Springer International Publishing
    • Related Report
      2015 Annual Research Report
  • [Remarks] 習慣流産・不育症の皆さんへ

    • URL

      http://www.med.nagoya-cu.ac.jp/obgyne.dir/group.huiku.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 習慣流産・不育症のみなさんへ

    • URL

      http://www.med.nagoya-cu.ac.jp/obgyne.dir/group_huiku.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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