| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
Six kinds of SNPs of ANXA5, CT genotype of coagulation factor XII (FXII) and GT and TT genotype of Ser156Ser of FV were found to be risk factors for recurrent pregnancy loss (RPL). The frequency of protein S (PS) Tokushima in patients was similar to that in controls. No case of Nara mutation and Hong Kong mutation were found in both patients and controls. There was no difference of subsequent live birth rate between with and without risk alleles of ANXA5, FXII, FV and PS Tokushima. There was no difference of subsequent live birth rate between low and normal levels of FXII activity, PS antigen, PS activity and PS specific activity after excluding cases with RPL caused by abnormal embryonic karyotype.
We found CT genotype of FXII as a risk factor for RPL at the first time. However, the genotyping of these risk alleles and testing for FXII activity and PS measurement were not necessary because of absence of clinical benefit.
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