Validation of the prediction of preeclampsia within 4 weeks using the onset threshold of plasma sFlt-1/PlGF ratio

• Project/Area Number: 24592482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Jichi Medical University
• Principal Investigator: Ohkuchi Akihide 自治医科大学, 医学部, 教授 (10306136)
• Research Collaborator: HIRASHIMA CHIKAKO (90348011) ; TAKAHASHI KAYO (00448854)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 妊娠高血圧腎症 / 発症予知 / sFlt-1/PlGF比 / 妊娠高血圧症候群 / sFlt-1 / PlGF

Outline of Final Research Achievements

This study is a validation study for our previous predictive study using onset threshold (Ohkuchi A, et al. Hypertens Res 2013; 36: 1073). We measured plasma levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio at 19-25, and 26-31 weeks of gestation in 127 high risk women, using ECLIA method. The primary outcome was the subsequent onset of preeclampsia (PE) after the blood sampling. As for the blood sampling at 19-25 weeks of gestation, the onset threshold (OT) of plasma level of sFlt-1/PlGF ratio yielded the sensitivity of 0/1 (0%), and specificity of 120/120 (100%). As for the blood sampling at 26-31 weeks of gestation, the OT yielded the sensitivity of 1/1 (100%), and specificity of 80/80 (100%). Thus, the usage of onset threshold of sFlt-1/PlGF ratio at 19-31 weeks of gestation may be clinically useful to rule out the imminent onset of PE within 4 weeks after the blood sampling.

Research Products

• [Journal Article] Prediction and prevention of hypertensive disorders of pregnancy. (2017)
  • Author(s): Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Matsubara S.
  • Journal Title: Hypertens Res Volume: 40 Issue: 1 Pages: 5-14
  • DOI: 10.1038/hr.2016.107
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion (2017)
  • Author(s): Takahashi H, Ohkuchi A, Kuwata T, Usui R, Baba Y, Suzuki H, Chaw Kyi TT, Matsubara S, Saito S, Takizawa T
  • Journal Title: Placenta Volume: 50 Pages: 25-31
  • DOI: 10.1016/j.placenta.2016.12.016
  • Peer Reviewed
• [Journal Article] Changes in Central Hemodynamics in Women With Hypertensive Pregnancy Between Before and After Delivery. (2016)
  • Author(s): Fukushima T, Eguchi K, Ohkuchi A, Miyashita H, Kario K.
  • Journal Title: J Clin Hypertens (Greenwich) Volume: 18 Issue: 4 Pages: 329-36
  • DOI: 10.1111/jch.12670
  • Peer Reviewed
• [Journal Article] Urinary protein-to-creatinine ratio indicative of significant proteinuria in normotensive pregnant women. (2016)
  • Author(s): Baba Y, Ohkuchi A, Usui R, Takahashi H, Matsubara S.
  • Journal Title: J Obstet Gynaecol Res Volume: 42 Issue: 7 Pages: 784-8
  • DOI: 10.1111/jog.13000
  • Peer Reviewed
• [Journal Article] Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study. (2016)
  • Author(s): Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Umazume T, Itakura A, Maeda M, Sagawa N, Ohno Y, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Nakai A, Minakami H.
  • Journal Title: Acta Obstet Gynecol Scand Volume: 95 Issue: 9 Pages: 1048-54
  • DOI: 10.1111/aogs.12915
  • NAID: 120006337755
  • Peer Reviewed
• [Journal Article] AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. (2016)
  • Author(s): Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
  • Journal Title: Am J Reprod Immunol Volume: 75 Issue: 5 Pages: 557-568
  • DOI: 10.1111/aji.12506
  • Peer Reviewed
• [Journal Article] Ambulatory BP monitoring and clinic BP in predicting small-for-gestational-age infants during pregnancy (2015)
  • Author(s): Eguchi K, Ohmaru T, Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Kario K
  • Journal Title: J Hum Hypertens Volume: in press Issue: 1 Pages: 62-7
  • DOI: 10.1038/jhh.2015.20
  • Peer Reviewed
• [Journal Article] Urinary protein-to-creatinine ratio in pregnant women after dipstick testing: prospective observational study. (2015)
  • Author(s): Baba Y, Yamada T, Obata-Yasuoka M, Yasuda S, Ohno Y, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Hamada H, Itakura A, Ohkuchi A, Maeda M, Sagawa N, Nakai A, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Minakami H.
  • Journal Title: BMC Pregnancy Childbirth Volume: 14 Issue: 1 Pages: 331-331
  • DOI: 10.1186/s12884-015-0776-9
  • NAID: 120007128510
  • Peer Reviewed
• [Journal Article] The Frequency of Peripheral Blood CD4+FoxP3+ Regulatory T Cells in Women With Pre-eclampsia and Those With High-risk Factors for Pre-eclampsia. (2015)
  • Author(s): Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S.
  • Journal Title: Hypertens Pregnancy Volume: 34 Issue: 4 Pages: 443-455
  • DOI: 10.3109/10641955.2015.1065884
  • Peer Reviewed
• [Journal Article] NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy. (2015)
  • Author(s): Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi M.
  • Journal Title: Endocrinology Volume: 156 Issue: 11 Pages: 4281-4292
  • DOI: 10.1210/en.2015-1408
  • Peer Reviewed / Open Access
• [Journal Article] Moderate Hypoxia Down-Regulates Interleukin-6 Secretion and TLR4 Expression in Human Sw.71 Placental Cells. (2015)
  • Author(s): Shirasuna K, Shimamura N, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
  • Journal Title: Cell Physiol Biochem Volume: 36 Issue: 6 Pages: 2149-2160
  • DOI: 10.1159/000430181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy. (2015)
  • Author(s): Ishida Y, Zhao D, Ohkuchi A, Kuwata T, Yoshitake H, Yuge K, Takizawa T, Matsubara S, Suzuki M, Saito S, Takizawa T
  • Journal Title: Int J Mol Med. Volume: 35 Issue: 6 Pages: 1511-1524
  • DOI: 10.3892/ijmm.2015.2157
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A novel three-step approach for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation. (2014)
  • Author(s): Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Matsubara S, Suzuki M.
  • Journal Title: Hypertens Res Volume: 37 Issue: 6 Pages: 519-525
  • DOI: 10.1038/hr.2014.31
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition (2014)
  • Author(s): Minakami, H. Maeda, T. Fujii, T. Hamada, H. Iitsuka, Y. Itakura, A. Itoh, H. Iwashita, M. Kanagawa, T., et al.
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 6 Pages: 1469-1499
  • DOI: 10.1111/jog.12419
  • Peer Reviewed
• [Journal Article] Differential expression of ADAM (a disintegrin and metalloproteinase) genes between human first trimester villous and extravillous trophoblast cells. (2014)
  • Author(s): Takahashi H, Yuge K, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Suzuki M, Takizawa T.
  • Journal Title: J Nippon Med S Volume: 81 Pages: 122-129
  • NAID: 130004147298
  • Peer Reviewed
• [Journal Article] Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells. (2014)
  • Author(s): Kambe S, Yoshitake H, Yuge K, Ishida Y, Moksed A, Takizawa T, Kuwata T, Ohkuchi A, Matsubara S, Suzuki M, Takeshita T, Saito S, Takizawa T
  • Journal Title: Biol Reprod Volume: 91 Issue: 5 Pages: 129-129
  • DOI: 10.1095/biolreprod.114.121616
  • Peer Reviewed
• [Journal Article] Recurrence Risk of Hypertensive Disease in Pregnancy (2014)
  • Author(s): Kayo Takahashi, Akihide Ohkuchi, Mami Kobayashi, Shigeki Matsubara, and Mitsuaki Suzuki
  • Journal Title: Med J Obset Gynecol Volume: 2 Pages: 1023-1023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prediction of Early-Onset Preeclampsia Using Uterine Artery Doppler (2014)
  • Author(s): Akihide Ohkuchi, Kayo Takahashi, Chikako Hirashima, RieUsui, Shigeki Matsubara and Mitsuaki Suzuki
  • Journal Title: Med J Obset Gynecol Volume: 2 Pages: 1026-1026
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prediction of Early-Onset Preeclampsia Using Angiogenesis-Related Factors (2014)
  • Author(s): Chikako Hirashima, Akihide Ohkuchi, Kayo Takahashi, Rie Usui, Shigeki Matsubara and Mitsuaki Suzuki
  • Journal Title: Med J Obstet Gynecol Volume: 2 Pages: 1025-1025
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Risk of Preeclampsia in Women with CKD, Dialysis or Kidney Transplantation (2014)
  • Author(s): Noriko Hirose, Akihide Ohkuchi, RieUsui, Shigeki Matsubara, and Mitsuaki Suzuki
  • Journal Title: Med J Obstet Gynecol Volume: 2 Pages: 1028-1028
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Risk Factors Associated with the Occurrence of Preeclampsia in Women with Twin Pregnancies: Mini Review (2014)
  • Author(s): Akihide Ohkuchi
  • Journal Title: Med J Obstet Gynecol Volume: 2 Pages: 1027-1027
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Role of the Father in the Occurrence of Preeclampsia (2014)
  • Author(s): Shiho Nagayama, Akihide Ohkuchi, RieUsui, Shigeki Matsubara, and Mitsuaki Suzuki
  • Journal Title: Med J Obstet Gynecol Volume: 2 Pages: 1029-1029
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Animal Models of Preeclampsia: Insight into Possible Biomarker Candidates for Predicting Preeclampsia (2014)
  • Author(s): Hirotada Suzuki, Akihide Ohkuchi, Koumei Shirasuna, Hironori Takahashi, Rie Usui, Shigeki Matsubara and Mitsuaki Suzuki
  • Journal Title: Med J Obstet Gynecol Volume: 2 Pages: 1031-1031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Importance of Chromosome 19 miRNA Cluster in Pregnancy (2014)
  • Author(s): Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Toshihiro Takizawa, Shigeki Matsubara and Mitsuaki Suzuki
  • Journal Title: Med J Obstet Gynecol Volume: 2 Pages: 1032-1032
  • Peer Reviewed
• [Journal Article] Increased antiangiogenetic factors in severe proteinuria without hypertension in pregnancy: is kidney biopsy necessary? (2014)
  • Author(s): Ohmaru T, Ohkuchi A, Muto S, Hirashima C, Matsubara S, Suzuki M
  • Journal Title: CEN Case Rep Volume: 3 Issue: 1 Pages: 86-89
  • DOI: 10.1007/s13730-013-0092-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Additive effects of mean blood pressure and bilateral notching in the second trimester on subsequent angiogenesis-related factors. (2014)
  • Author(s): Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Matsuda Y, Matsubara S, Suzuki M
  • Journal Title: Hypertens Res Volume: 37 Issue: 1 Pages: 76-81
  • DOI: 10.1038/hr.2013.88
  • Peer Reviewed
• [Journal Article] Maternal manifestation of Ballantyne's syndrome occurring concomitantly with the development of fetal congenital mesoblastic nephroma. (2014)
  • Author(s): Takahashi H, Matsubara S, Kuwata T, Ohkuchi A, Mukoda Y, Saito K, Usui R, Suzuki M
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 4 Pages: 1114-7
  • DOI: 10.1111/jog.12286
  • Peer Reviewed
• [Journal Article] Changes in expression of vascular endothelial growth factor D-related genes in placental mesenchymal dysplasia (2014)
  • Author(s): Hironori Takahashi, Shigeki Matsubara, Tomoyuki Kuwata, Miyuki Saruyama, Rie Usui, Akihide Ohkuchi, Toshihiro Takizawa, Mitsuaki Suzuki
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 4 Pages: 1145-1149
  • DOI: 10.1111/jog.12291
  • Peer Reviewed / Open Access
• [Journal Article] Onset threshold of the plasma levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation. (2013)
  • Author(s): Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Matsubara S, Suzuki M
  • Journal Title: Hypertens Res Volume: 36 Issue: 12 Pages: 1073-80
  • DOI: 10.1038/hr.2013.95
  • Peer Reviewed
• [Journal Article] Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction. (2013)
  • Author(s): Takahashi H, Takizawa T, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Matsumoto H, Sato Y, Fujiwara H, Okamoto A, Suzuki M, Takizawa T
  • Journal Title: Placenta Volume: 35 Pages: 163-70
  • Peer Reviewed
• [Journal Article] Committee report on cerebrovascular disorders, including eclampsia and emergency medical services, of the Japan Society for the Study of Hypertension in Pregnancy (2013)
  • Author(s): Suzuki Y, Adachi T, Ohno Y, Matsuda H, Naruse K, Metoki H, Nakai Y, Nakamoto O, Watanabe K, Ohkuchi A, Yamamoto T
  • Journal Title: Hypertension Research in Pregnancy Volume: 1 Issue: 1 Pages: 8-12
  • DOI: 10.14390/jsshp.1.8
  • NAID: 130005002838
  • ISSN: 2187-5987, 2187-9931
  • Peer Reviewed
• [Journal Article] Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset preeclampsia: A prospective cohort study. (2013)
  • Author(s): Takahashi K, Ohkuchi A, Suzuki H, Usui R, Kuwata T, Shirasuna K, Matsubara S, Suzuki M
  • Journal Title: Pregnancy Hypertens Volume: 3 Issue: 4 Pages: 270-277
  • DOI: 10.1016/j.preghy.2013.07.006
  • Peer Reviewed
• [Journal Article] Adenomyomectomy, curettage, and then uterine artery pseudoaneurysm occupying the entire uterine cavity. (2013)
  • Author(s): Matsubara S, Usui R, Sato T, Kuwata T, Ohkuchi A, Nakata M.
  • Journal Title: J Obstet Gynaecol Res Volume: 39 Issue: 5 Pages: 1103-6
  • DOI: 10.1111/jog.12021
  • Peer Reviewed
• [Journal Article] 'Holding the cervix' technique for post-partum hemorrhage for achieving hemostasis as well as preventing prolapse of an intrauterine balloon. (2013)
  • Author(s): Matsubara S, Kuwata T, Usui R, Ohkuchi A.
  • Journal Title: J Obstet Gynaecol Res Volume: 39 Issue: 5 Pages: 1116-7
  • DOI: 10.1111/jog.12019
  • Peer Reviewed
• [Journal Article] Uterine compression sutures for postpartum hemorrhage: an overview. (2013)
  • Author(s): Matsubara S, Yano H, Ohkuchi A, Kuwata T, Usui R, Suzuki M.
  • Journal Title: Acta Obstet Gynecol Scand Volume: 92 Issue: 4 Pages: 378-85
  • DOI: 10.1111/aogs.12077
  • Peer Reviewed
• [Journal Article] Important surgical measures and techniques at cesarean hysterectomy for placenta previa accreta. (2013)
  • Author(s): Matsubara S, Yano H, Ohkuchi A, Kuwata T, Usui R, Suzuki M.
  • Journal Title: Acta Obstet Gynecol Scand Volume: 92 Issue: 4 Pages: 372-7
  • DOI: 10.1111/aogs.12074
  • Peer Reviewed
• [Journal Article] Oral health care during pregnancy: four aims may be too many. (2012)
  • Author(s): Matsubara S, Kuwata T, Ohkuchi A.
  • Journal Title: Rural Remote Health Volume: 12 Pages: 2294-2294
  • Peer Reviewed
• [Journal Article] Plasma level of hydroxysteroid (17-β) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio. (2012)
  • Author(s): Ohkuchi A, Ishibashi O, Hirashima C, Takahashi K, Matsubara S, Takizawa T, Suzuki M.
  • Journal Title: Hypertens Res Volume: 35 Issue: 12 Pages: 1152-1158
  • DOI: 10.1038/hr.2012.109
  • Peer Reviewed
• [Journal Article] Establishing reference values for mean notch depth index, pulsatility index and resistance index in the uterine artery at 16-23 weeks' gestation. (2012)
  • Author(s): Takahashi K, Ohkuchi A, Hirashima C, Matsubara S, Suzuki M.
  • Journal Title: J Obstet Gynaecol Res Volume: 38 Issue: 11 Pages: 1275-85
  • DOI: 10.1111/j.1447-0756.2012.01864.x
  • Peer Reviewed
• [Journal Article] Initial dose of vancomycin based on body weight and creatinine clearance to minimize inadequate trough levels in Japanese adults. (2012)
  • Author(s): Maki N, Ohkuchi A, Tashiro Y, Kim MR, Le M, Sakamoto T, Matsubara S, Hakamata Y.
  • Journal Title: Eur J Clin Microbiol Infect Dis Volume: 31 Issue: 10 Pages: 2537-43
  • DOI: 10.1007/s10096-012-1593-y
  • Peer Reviewed
• [Presentation] White coat hypertension in pregnancy: high incidence rates of gestational hypertension and preeclampsia (2016)
  • Author(s): Ohkuchi A, Takahashi K, Hirashima C, Suzuki H, Nagayama S, Takahashi H, Eguchi K, Matsubara S.
  • Organizer: The XX World Congress of ISSHP
  • Place of Presentation: the Maksoud Plaza Hotel (Sao Paulo, Brazil)
  • Year and Date: 2016-10-23
  • Int'l Joint Research
• [Presentation] 糖尿病性慢性腎不全妊婦における透析中のsoluble fms-like tyrosine kinase (sFlt)-1変化 (2016)
  • Author(s): 佐野実穂，森澤宏行，大口昭英，高橋宏典，平嶋周子，薄井里英，安藤明彦，森下義幸，松原茂樹
  • Organizer: 第26回腎と妊娠研究会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2016-03-05
• [Presentation] 妊娠高血圧腎症妊婦における赤血球膜脂肪酸のω9一価不飽和酸重量比率と血清PlGF濃度との正相関 (2016)
  • Author(s): 小林真実，大口昭英，平嶋周子，高橋佳代，鈴木寛正，森澤宏行，松原茂樹
  • Organizer: 第26回腎と妊娠研究会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2016-03-05
• [Presentation] 糖尿病家族歴、高血圧家族歴の妊娠糖尿病、妊娠高血圧、及び、妊娠高血圧腎症発症に及ぼす影響：多変量解析 (2015)
  • Author(s): 永山志穂、高橋佳代、大口昭英、平嶋周子、猿山美幸、鈴木寛正、松原茂樹
  • Organizer: 第39回日本産婦人科栄養・代謝研究会
  • Place of Presentation: 東京医科歯科大学 MDタワー
  • Year and Date: 2015-08-22
• [Presentation] 蛋白／クレアチニン比と24時間尿中蛋白尿との関係の再検討 正常血圧妊婦を中心に (2015)
  • Author(s): 馬場洋介，松原茂樹，大口昭英，桑田知之，薄井里英，高橋宏典，鈴木寛正，廣瀬典子，永山志穂，小古山 学，猿山美幸
  • Organizer: 第51回日本周産期・新生児医学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク
  • Year and Date: 2015-07-11
• [Presentation] sFlt-1が異常高値を示した急性妊娠脂肪肝 症例報告 (2015)
  • Author(s): 鈴木寛正，大口昭英，平嶋周子，高橋佳代，森澤宏行，永山志穂，高橋宏典，馬場洋介，桑田知之，薄井里英，渡辺 尚，松原茂樹
  • Organizer: 第51回日本周産期・新生児医学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク
  • Year and Date: 2015-07-11
• [Presentation] 妊娠高血圧腎症における赤血球膜脂肪酸組成中の飽和、一価不飽和、ω-3脂肪酸比率 (2015)
  • Author(s): 小林真実、廣瀬典子、大口昭英、大丸貴子、松原茂樹、鈴木光明
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-12
• [Presentation] 家庭血圧測定における変曲点の在胎週数、血圧レベル、及び、その後2週間の血圧増加速度を用いた妊娠高血圧腎症並びに妊娠高血圧の発症予知 (2015)
  • Author(s): 猿山美幸、大口昭英、高橋佳代、大丸貴子、平嶋周子、鈴木寛正、松原茂樹、鈴木光明
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-12
• [Presentation] 妊娠中期の血清galectin-1低値と、妊娠高血圧腎症及び妊娠高血圧の発症リスク (2015)
  • Author(s): 鈴木寛正、平嶋周子、大口昭英、高橋佳代、永山志穂、高橋宏典、猿山美幸、薄井里英、松原茂樹、鈴木光明
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-12
• [Presentation] 妊娠中期、後期前半の胎盤成長因子濃度とその後のSGA児及びsmall placenta発生との関連 (2015)
  • Author(s): 平嶋周子、大口昭英、高橋佳代、鈴木寛正、松原茂樹、鈴木光明
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-10
• [Presentation] 糖尿病家族歴と妊娠糖尿病、妊娠高血圧あるいは妊娠高血圧腎症発症との関係 (2015)
  • Author(s): 永山志穂、高橋佳代、大口昭英、平嶋周子、猿山美幸、鈴木寛正、松原茂樹、鈴木光明
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-10
• [Presentation] 妊娠初期栄養膜細胞におけるa Disintegrin and Metalloproteinase(ADAM)ファミリーの発現：絨毛外栄養膜細胞浸潤へのADAM関与可能性 (2015)
  • Author(s): 高橋宏典、松原茂樹、大口昭英、薄井里英、桑田知之、馬場洋介、鈴木寛正、瀧澤俊広、鈴木光明
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-10
• [Presentation] 妊娠高血圧症候群と血管新生関連因子 (2014)
  • Author(s): 大口昭英，鈴木寛正，平嶋周子，高橋佳代，松原茂樹，鈴木光明
  • Organizer: 第29回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 伊藤国際学術研究センター
  • Year and Date: 2014-12-12
• [Presentation] Decreased circulating levels of galectin-1 in the second trimester as an independent risk factor for not only preeclampsia but also gestational hypertension. (2014)
  • Author(s): Ohkuchi A, Hirashima C, Nagayama S, Suzuki H, Takahashi K, Matsubara S, Suzuki M.
  • Organizer: XIX International society for the study of hypertension in pregnancy (ISSHP) World Congress
  • Place of Presentation: Hilton – New Orleans Riverside
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] 妊娠中の自由行動下血圧指標はSmall for Gestational Ageに関連している． (2014)
  • Author(s): 江口和男, 大丸貴子, 大口昭英, 平嶋周子, 高橋佳代, 鈴木寛正, 苅尾七臣, 松原茂樹, 鈴木光明
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] 妊娠中期、後期前半のsFlt-1/PIGF比、及び、soluble endoglinによる妊娠高血圧腎症発症リスク評価 (2014)
  • Author(s): 平嶋周子, 大口昭英, 高橋佳代, 松原茂樹, 鈴木光明
  • Organizer: 第35回日本妊娠高血圧学会
  • Place of Presentation: 京王プラザ
  • Year and Date: 2014-09-20
• [Presentation] The existence of inflection point in home blood pressure monitoring at earlier gestational weeks in preeclampsia and gestational hypertension. (2014)
  • Author(s): Saruyama M, Ohkuchi A, Takahashi K, Ohmaru T, Hirashima C, Suzuki H, Matsubara S, Suzuki M.
  • Organizer: 46th International Congress on Pathophysiology of Pregnancy.
  • Place of Presentation: Keio Plaza Hotel
  • Year and Date: 2014-09-19
• [Presentation] Prediction of preeclampsia using angiogenesis-reltaed factors or home blood pressure monitoring. (2014)
  • Author(s): Ohkuchi A, HIrashima C, Saruyama M, Takahashi K, Ohmaru T, Suzuki H, Matsubara S, Suzuki M.
  • Organizer: Workshop on the 46th International Congress on Pathophysiology of Pregnancy.
  • Place of Presentation: Keio Plaza Hotel
  • Year and Date: 2014-09-19
• [Presentation] 妊娠高血圧症候群既往歴は、血圧高値と子宮動脈血流速度異常とは独立した妊娠高血圧腎症の危険因子である (2014)
  • Author(s): 小林真実、高橋佳代、大口昭英、鈴木寛正、有賀治子、廣瀬典子、平嶋周子、松原茂樹、鈴木光明
  • Organizer: 第66回日本産婦人科学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2014-04-19
• [Presentation] 塩酸リトドリンの副反応とその対応について (2013)
  • Author(s): 大口昭英、堀江健司、鈴木寛正、桑田知之、薄井里英、松原茂樹、鈴木光明
  • Organizer: 第7回日本早産予防研究会学術集会
  • Place of Presentation: 日本医科大学附属武蔵小杉病院
• [Presentation] 妊娠36週未満発症の妊娠高血圧腎症の発症予知法の改良－血中血管新生関連因子の正常域から疾患発症閾値への展開－ (2013)
  • Author(s): 大口昭英
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: ロイトン札幌、ホテルさっぽろ芸文館（旧北海道厚生年金会館）、札幌プリンスホテル
• [Presentation] 観察研究の進め方 (2013)
  • Author(s): 大口昭英
  • Organizer: 日本消化器内視鏡学会茨城県部会第25回研究会
  • Place of Presentation: オークラフロンティア ホテルつくばアネックス
  • Invited
• [Presentation] The preceding features before onset of gestational hypertension and preeclampsia in home blood pressure monitoring: the existence of the inflection point and the rapid increased speed of blood pressure (2012)
  • Author(s): Takako Ohmaru, Akinori Miki, Kayo Takahashi, Akihide Ohkuchi, Atsuo Itakura, Shigeki Matsubara, Mitsuaki Suzuki
  • Organizer: XVIII International Society for the Study of Hypertension in Pregnancy (ISSHP) World Congress
  • Place of Presentation: Geneva
• [Presentation] THE ADDITIVE EFFECT OF PLASMA LEVELS OF SFLT-1/PLGF RATIO FOLLOWING THE RISK CLASSIFICATION USING BOTH BLOOD PRESSURE LEVELS AND UTERINE ARTERY BLOOD FLOW IMPEDANCE IN THE SECOND TRIMESTER ON THE LATER OCCURRENCE OF PREECLAMPSIA (2012)
  • Author(s): Akihide Ohkuchi, Chikako Hirashima, Kayo Takahashi, Sigeki Matsubara, Mitsuaki Suzuki
  • Organizer: XVIII International Society for the Study of Hypertension in Pregnancy (ISSHP) World Congress
  • Place of Presentation: Geneva