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Validation of the prediction of preeclampsia within 4 weeks using the onset threshold of plasma sFlt-1/PlGF ratio

Research Project

Project/Area Number 24592482
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionJichi Medical University

Principal Investigator

Ohkuchi Akihide  自治医科大学, 医学部, 教授 (10306136)

Research Collaborator HIRASHIMA CHIKAKO   (90348011)
TAKAHASHI KAYO   (00448854)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords妊娠高血圧腎症 / 発症予知 / sFlt-1/PlGF比 / 妊娠高血圧症候群 / sFlt-1 / PlGF
Outline of Final Research Achievements

This study is a validation study for our previous predictive study using onset threshold (Ohkuchi A, et al. Hypertens Res 2013; 36: 1073). We measured plasma levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio at 19-25, and 26-31 weeks of gestation in 127 high risk women, using ECLIA method. The primary outcome was the subsequent onset of preeclampsia (PE) after the blood sampling. As for the blood sampling at 19-25 weeks of gestation, the onset threshold (OT) of plasma level of sFlt-1/PlGF ratio yielded the sensitivity of 0/1 (0%), and specificity of 120/120 (100%). As for the blood sampling at 26-31 weeks of gestation, the OT yielded the sensitivity of 1/1 (100%), and specificity of 80/80 (100%). Thus, the usage of onset threshold of sFlt-1/PlGF ratio at 19-31 weeks of gestation may be clinically useful to rule out the imminent onset of PE within 4 weeks after the blood sampling.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (64 results)

All 2017 2016 2015 2014 2013 2012

All Journal Article (40 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 40 results,  Acknowledgement Compliant: 11 results,  Open Access: 4 results) Presentation (24 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Prediction and prevention of hypertensive disorders of pregnancy.2017

    • Author(s)
      Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Matsubara S.
    • Journal Title

      Hypertens Res

      Volume: 40 Issue: 1 Pages: 5-14

    • DOI

      10.1038/hr.2016.107

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion2017

    • Author(s)
      Takahashi H, Ohkuchi A, Kuwata T, Usui R, Baba Y, Suzuki H, Chaw Kyi TT, Matsubara S, Saito S, Takizawa T
    • Journal Title

      Placenta

      Volume: 50 Pages: 25-31

    • DOI

      10.1016/j.placenta.2016.12.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Central Hemodynamics in Women With Hypertensive Pregnancy Between Before and After Delivery.2016

    • Author(s)
      Fukushima T, Eguchi K, Ohkuchi A, Miyashita H, Kario K.
    • Journal Title

      J Clin Hypertens (Greenwich)

      Volume: 18 Issue: 4 Pages: 329-36

    • DOI

      10.1111/jch.12670

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urinary protein-to-creatinine ratio indicative of significant proteinuria in normotensive pregnant women.2016

    • Author(s)
      Baba Y, Ohkuchi A, Usui R, Takahashi H, Matsubara S.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 42 Issue: 7 Pages: 784-8

    • DOI

      10.1111/jog.13000

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study.2016

    • Author(s)
      Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Umazume T, Itakura A, Maeda M, Sagawa N, Ohno Y, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Nakai A, Minakami H.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 95 Issue: 9 Pages: 1048-54

    • DOI

      10.1111/aogs.12915

    • NAID

      120006337755

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration.2016

    • Author(s)
      Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
    • Journal Title

      Am J Reprod Immunol

      Volume: 75 Issue: 5 Pages: 557-568

    • DOI

      10.1111/aji.12506

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ambulatory BP monitoring and clinic BP in predicting small-for-gestational-age infants during pregnancy2015

    • Author(s)
      Eguchi K, Ohmaru T, Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Kario K
    • Journal Title

      J Hum Hypertens

      Volume: in press Issue: 1 Pages: 62-7

    • DOI

      10.1038/jhh.2015.20

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urinary protein-to-creatinine ratio in pregnant women after dipstick testing: prospective observational study.2015

    • Author(s)
      Baba Y, Yamada T, Obata-Yasuoka M, Yasuda S, Ohno Y, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Hamada H, Itakura A, Ohkuchi A, Maeda M, Sagawa N, Nakai A, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Minakami H.
    • Journal Title

      BMC Pregnancy Childbirth

      Volume: 14 Issue: 1 Pages: 331-331

    • DOI

      10.1186/s12884-015-0776-9

    • NAID

      120007128510

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Frequency of Peripheral Blood CD4+FoxP3+ Regulatory T Cells in Women With Pre-eclampsia and Those With High-risk Factors for Pre-eclampsia.2015

    • Author(s)
      Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S.
    • Journal Title

      Hypertens Pregnancy

      Volume: 34 Issue: 4 Pages: 443-455

    • DOI

      10.3109/10641955.2015.1065884

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy.2015

    • Author(s)
      Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi M.
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 11 Pages: 4281-4292

    • DOI

      10.1210/en.2015-1408

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Moderate Hypoxia Down-Regulates Interleukin-6 Secretion and TLR4 Expression in Human Sw.71 Placental Cells.2015

    • Author(s)
      Shirasuna K, Shimamura N, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
    • Journal Title

      Cell Physiol Biochem

      Volume: 36 Issue: 6 Pages: 2149-2160

    • DOI

      10.1159/000430181

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy.2015

    • Author(s)
      Ishida Y, Zhao D, Ohkuchi A, Kuwata T, Yoshitake H, Yuge K, Takizawa T, Matsubara S, Suzuki M, Saito S, Takizawa T
    • Journal Title

      Int J Mol Med.

      Volume: 35 Issue: 6 Pages: 1511-1524

    • DOI

      10.3892/ijmm.2015.2157

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel three-step approach for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation.2014

    • Author(s)
      Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Matsubara S, Suzuki M.
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 6 Pages: 519-525

    • DOI

      10.1038/hr.2014.31

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition2014

    • Author(s)
      Minakami, H. Maeda, T. Fujii, T. Hamada, H. Iitsuka, Y. Itakura, A. Itoh, H. Iwashita, M. Kanagawa, T., et al.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 6 Pages: 1469-1499

    • DOI

      10.1111/jog.12419

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential expression of ADAM (a disintegrin and metalloproteinase) genes between human first trimester villous and extravillous trophoblast cells.2014

    • Author(s)
      Takahashi H, Yuge K, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Suzuki M, Takizawa T.
    • Journal Title

      J Nippon Med S

      Volume: 81 Pages: 122-129

    • NAID

      130004147298

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells.2014

    • Author(s)
      Kambe S, Yoshitake H, Yuge K, Ishida Y, Moksed A, Takizawa T, Kuwata T, Ohkuchi A, Matsubara S, Suzuki M, Takeshita T, Saito S, Takizawa T
    • Journal Title

      Biol Reprod

      Volume: 91 Issue: 5 Pages: 129-129

    • DOI

      10.1095/biolreprod.114.121616

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrence Risk of Hypertensive Disease in Pregnancy2014

    • Author(s)
      Kayo Takahashi, Akihide Ohkuchi, Mami Kobayashi, Shigeki Matsubara, and Mitsuaki Suzuki
    • Journal Title

      Med J Obset Gynecol

      Volume: 2 Pages: 1023-1023

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prediction of Early-Onset Preeclampsia Using Uterine Artery Doppler2014

    • Author(s)
      Akihide Ohkuchi, Kayo Takahashi, Chikako Hirashima, RieUsui, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obset Gynecol

      Volume: 2 Pages: 1026-1026

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prediction of Early-Onset Preeclampsia Using Angiogenesis-Related Factors2014

    • Author(s)
      Chikako Hirashima, Akihide Ohkuchi, Kayo Takahashi, Rie Usui, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1025-1025

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Risk of Preeclampsia in Women with CKD, Dialysis or Kidney Transplantation2014

    • Author(s)
      Noriko Hirose, Akihide Ohkuchi, RieUsui, Shigeki Matsubara, and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1028-1028

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Risk Factors Associated with the Occurrence of Preeclampsia in Women with Twin Pregnancies: Mini Review2014

    • Author(s)
      Akihide Ohkuchi
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1027-1027

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Role of the Father in the Occurrence of Preeclampsia2014

    • Author(s)
      Shiho Nagayama, Akihide Ohkuchi, RieUsui, Shigeki Matsubara, and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1029-1029

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Animal Models of Preeclampsia: Insight into Possible Biomarker Candidates for Predicting Preeclampsia2014

    • Author(s)
      Hirotada Suzuki, Akihide Ohkuchi, Koumei Shirasuna, Hironori Takahashi, Rie Usui, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1031-1031

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Importance of Chromosome 19 miRNA Cluster in Pregnancy2014

    • Author(s)
      Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Toshihiro Takizawa, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1032-1032

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased antiangiogenetic factors in severe proteinuria without hypertension in pregnancy: is kidney biopsy necessary?2014

    • Author(s)
      Ohmaru T, Ohkuchi A, Muto S, Hirashima C, Matsubara S, Suzuki M
    • Journal Title

      CEN Case Rep

      Volume: 3 Issue: 1 Pages: 86-89

    • DOI

      10.1007/s13730-013-0092-z

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Additive effects of mean blood pressure and bilateral notching in the second trimester on subsequent angiogenesis-related factors.2014

    • Author(s)
      Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Matsuda Y, Matsubara S, Suzuki M
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 1 Pages: 76-81

    • DOI

      10.1038/hr.2013.88

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal manifestation of Ballantyne's syndrome occurring concomitantly with the development of fetal congenital mesoblastic nephroma.2014

    • Author(s)
      Takahashi H, Matsubara S, Kuwata T, Ohkuchi A, Mukoda Y, Saito K, Usui R, Suzuki M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 4 Pages: 1114-7

    • DOI

      10.1111/jog.12286

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in expression of vascular endothelial growth factor D-related genes in placental mesenchymal dysplasia2014

    • Author(s)
      Hironori Takahashi, Shigeki Matsubara, Tomoyuki Kuwata, Miyuki Saruyama, Rie Usui, Akihide Ohkuchi, Toshihiro Takizawa, Mitsuaki Suzuki
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 4 Pages: 1145-1149

    • DOI

      10.1111/jog.12291

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Onset threshold of the plasma levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation.2013

    • Author(s)
      Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Matsubara S, Suzuki M
    • Journal Title

      Hypertens Res

      Volume: 36 Issue: 12 Pages: 1073-80

    • DOI

      10.1038/hr.2013.95

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction.2013

    • Author(s)
      Takahashi H, Takizawa T, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Matsumoto H, Sato Y, Fujiwara H, Okamoto A, Suzuki M, Takizawa T
    • Journal Title

      Placenta

      Volume: 35 Pages: 163-70

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Committee report on cerebrovascular disorders, including eclampsia and emergency medical services, of the Japan Society for the Study of Hypertension in Pregnancy2013

    • Author(s)
      Suzuki Y, Adachi T, Ohno Y, Matsuda H, Naruse K, Metoki H, Nakai Y, Nakamoto O, Watanabe K, Ohkuchi A, Yamamoto T
    • Journal Title

      Hypertension Research in Pregnancy

      Volume: 1 Issue: 1 Pages: 8-12

    • DOI

      10.14390/jsshp.1.8

    • NAID

      130005002838

    • ISSN
      2187-5987, 2187-9931
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset preeclampsia: A prospective cohort study.2013

    • Author(s)
      Takahashi K, Ohkuchi A, Suzuki H, Usui R, Kuwata T, Shirasuna K, Matsubara S, Suzuki M
    • Journal Title

      Pregnancy Hypertens

      Volume: 3 Issue: 4 Pages: 270-277

    • DOI

      10.1016/j.preghy.2013.07.006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adenomyomectomy, curettage, and then uterine artery pseudoaneurysm occupying the entire uterine cavity.2013

    • Author(s)
      Matsubara S, Usui R, Sato T, Kuwata T, Ohkuchi A, Nakata M.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 39 Issue: 5 Pages: 1103-6

    • DOI

      10.1111/jog.12021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 'Holding the cervix' technique for post-partum hemorrhage for achieving hemostasis as well as preventing prolapse of an intrauterine balloon.2013

    • Author(s)
      Matsubara S, Kuwata T, Usui R, Ohkuchi A.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 39 Issue: 5 Pages: 1116-7

    • DOI

      10.1111/jog.12019

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uterine compression sutures for postpartum hemorrhage: an overview.2013

    • Author(s)
      Matsubara S, Yano H, Ohkuchi A, Kuwata T, Usui R, Suzuki M.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 92 Issue: 4 Pages: 378-85

    • DOI

      10.1111/aogs.12077

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Important surgical measures and techniques at cesarean hysterectomy for placenta previa accreta.2013

    • Author(s)
      Matsubara S, Yano H, Ohkuchi A, Kuwata T, Usui R, Suzuki M.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 92 Issue: 4 Pages: 372-7

    • DOI

      10.1111/aogs.12074

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral health care during pregnancy: four aims may be too many.2012

    • Author(s)
      Matsubara S, Kuwata T, Ohkuchi A.
    • Journal Title

      Rural Remote Health

      Volume: 12 Pages: 2294-2294

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma level of hydroxysteroid (17-β) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio.2012

    • Author(s)
      Ohkuchi A, Ishibashi O, Hirashima C, Takahashi K, Matsubara S, Takizawa T, Suzuki M.
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 12 Pages: 1152-1158

    • DOI

      10.1038/hr.2012.109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishing reference values for mean notch depth index, pulsatility index and resistance index in the uterine artery at 16-23 weeks' gestation.2012

    • Author(s)
      Takahashi K, Ohkuchi A, Hirashima C, Matsubara S, Suzuki M.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 38 Issue: 11 Pages: 1275-85

    • DOI

      10.1111/j.1447-0756.2012.01864.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Initial dose of vancomycin based on body weight and creatinine clearance to minimize inadequate trough levels in Japanese adults.2012

    • Author(s)
      Maki N, Ohkuchi A, Tashiro Y, Kim MR, Le M, Sakamoto T, Matsubara S, Hakamata Y.
    • Journal Title

      Eur J Clin Microbiol Infect Dis

      Volume: 31 Issue: 10 Pages: 2537-43

    • DOI

      10.1007/s10096-012-1593-y

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] White coat hypertension in pregnancy: high incidence rates of gestational hypertension and preeclampsia2016

    • Author(s)
      Ohkuchi A, Takahashi K, Hirashima C, Suzuki H, Nagayama S, Takahashi H, Eguchi K, Matsubara S.
    • Organizer
      The XX World Congress of ISSHP
    • Place of Presentation
      the Maksoud Plaza Hotel (Sao Paulo, Brazil)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病性慢性腎不全妊婦における透析中のsoluble fms-like tyrosine kinase (sFlt)-1変化2016

    • Author(s)
      佐野実穂,森澤宏行,大口昭英,高橋宏典,平嶋周子,薄井里英,安藤明彦,森下義幸,松原茂樹
    • Organizer
      第26回腎と妊娠研究会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧腎症妊婦における赤血球膜脂肪酸のω9一価不飽和酸重量比率と血清PlGF濃度との正相関2016

    • Author(s)
      小林真実,大口昭英,平嶋周子,高橋佳代,鈴木寛正,森澤宏行,松原茂樹
    • Organizer
      第26回腎と妊娠研究会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病家族歴、高血圧家族歴の妊娠糖尿病、妊娠高血圧、及び、妊娠高血圧腎症発症に及ぼす影響:多変量解析2015

    • Author(s)
      永山志穂、高橋佳代、大口昭英、平嶋周子、猿山美幸、鈴木寛正、松原茂樹
    • Organizer
      第39回日本産婦人科栄養・代謝研究会
    • Place of Presentation
      東京医科歯科大学 MDタワー
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 蛋白/クレアチニン比と24時間尿中蛋白尿との関係の再検討 正常血圧妊婦を中心に2015

    • Author(s)
      馬場洋介,松原茂樹,大口昭英,桑田知之,薄井里英,高橋宏典,鈴木寛正,廣瀬典子,永山志穂,小古山 学,猿山美幸
    • Organizer
      第51回日本周産期・新生児医学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] sFlt-1が異常高値を示した急性妊娠脂肪肝 症例報告2015

    • Author(s)
      鈴木寛正,大口昭英,平嶋周子,高橋佳代,森澤宏行,永山志穂,高橋宏典,馬場洋介,桑田知之,薄井里英,渡辺 尚,松原茂樹
    • Organizer
      第51回日本周産期・新生児医学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧腎症における赤血球膜脂肪酸組成中の飽和、一価不飽和、ω-3脂肪酸比率2015

    • Author(s)
      小林真実、廣瀬典子、大口昭英、大丸貴子、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 家庭血圧測定における変曲点の在胎週数、血圧レベル、及び、その後2週間の血圧増加速度を用いた妊娠高血圧腎症並びに妊娠高血圧の発症予知2015

    • Author(s)
      猿山美幸、大口昭英、高橋佳代、大丸貴子、平嶋周子、鈴木寛正、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠中期の血清galectin-1低値と、妊娠高血圧腎症及び妊娠高血圧の発症リスク2015

    • Author(s)
      鈴木寛正、平嶋周子、大口昭英、高橋佳代、永山志穂、高橋宏典、猿山美幸、薄井里英、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠中期、後期前半の胎盤成長因子濃度とその後のSGA児及びsmall placenta発生との関連2015

    • Author(s)
      平嶋周子、大口昭英、高橋佳代、鈴木寛正、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病家族歴と妊娠糖尿病、妊娠高血圧あるいは妊娠高血圧腎症発症との関係2015

    • Author(s)
      永山志穂、高橋佳代、大口昭英、平嶋周子、猿山美幸、鈴木寛正、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠初期栄養膜細胞におけるa Disintegrin and Metalloproteinase(ADAM)ファミリーの発現:絨毛外栄養膜細胞浸潤へのADAM関与可能性2015

    • Author(s)
      高橋宏典、松原茂樹、大口昭英、薄井里英、桑田知之、馬場洋介、鈴木寛正、瀧澤俊広、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠高血圧症候群と血管新生関連因子2014

    • Author(s)
      大口昭英,鈴木寛正,平嶋周子,高橋佳代,松原茂樹,鈴木光明
    • Organizer
      第29回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      伊藤国際学術研究センター
    • Year and Date
      2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Decreased circulating levels of galectin-1 in the second trimester as an independent risk factor for not only preeclampsia but also gestational hypertension.2014

    • Author(s)
      Ohkuchi A, Hirashima C, Nagayama S, Suzuki H, Takahashi K, Matsubara S, Suzuki M.
    • Organizer
      XIX International society for the study of hypertension in pregnancy (ISSHP) World Congress
    • Place of Presentation
      Hilton – New Orleans Riverside
    • Year and Date
      2014-10-26 – 2014-10-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠中の自由行動下血圧指標はSmall for Gestational Ageに関連している.2014

    • Author(s)
      江口和男, 大丸貴子, 大口昭英, 平嶋周子, 高橋佳代, 鈴木寛正, 苅尾七臣, 松原茂樹, 鈴木光明
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠中期、後期前半のsFlt-1/PIGF比、及び、soluble endoglinによる妊娠高血圧腎症発症リスク評価2014

    • Author(s)
      平嶋周子, 大口昭英, 高橋佳代, 松原茂樹, 鈴木光明
    • Organizer
      第35回日本妊娠高血圧学会
    • Place of Presentation
      京王プラザ
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] The existence of inflection point in home blood pressure monitoring at earlier gestational weeks in preeclampsia and gestational hypertension.2014

    • Author(s)
      Saruyama M, Ohkuchi A, Takahashi K, Ohmaru T, Hirashima C, Suzuki H, Matsubara S, Suzuki M.
    • Organizer
      46th International Congress on Pathophysiology of Pregnancy.
    • Place of Presentation
      Keio Plaza Hotel
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Prediction of preeclampsia using angiogenesis-reltaed factors or home blood pressure monitoring.2014

    • Author(s)
      Ohkuchi A, HIrashima C, Saruyama M, Takahashi K, Ohmaru T, Suzuki H, Matsubara S, Suzuki M.
    • Organizer
      Workshop on the 46th International Congress on Pathophysiology of Pregnancy.
    • Place of Presentation
      Keio Plaza Hotel
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠高血圧症候群既往歴は、血圧高値と子宮動脈血流速度異常とは独立した妊娠高血圧腎症の危険因子である2014

    • Author(s)
      小林真実、高橋佳代、大口昭英、鈴木寛正、有賀治子、廣瀬典子、平嶋周子、松原茂樹、鈴木光明
    • Organizer
      第66回日本産婦人科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 塩酸リトドリンの副反応とその対応について2013

    • Author(s)
      大口昭英、堀江健司、鈴木寛正、桑田知之、薄井里英、松原茂樹、鈴木光明
    • Organizer
      第7回日本早産予防研究会学術集会
    • Place of Presentation
      日本医科大学附属武蔵小杉病院
    • Related Report
      2013 Research-status Report
  • [Presentation] 妊娠36週未満発症の妊娠高血圧腎症の発症予知法の改良-血中血管新生関連因子の正常域から疾患発症閾値への展開-2013

    • Author(s)
      大口昭英
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌、ホテルさっぽろ芸文館(旧北海道厚生年金会館)、札幌プリンスホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] 観察研究の進め方2013

    • Author(s)
      大口昭英
    • Organizer
      日本消化器内視鏡学会茨城県部会第25回研究会
    • Place of Presentation
      オークラフロンティア ホテルつくばアネックス
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The preceding features before onset of gestational hypertension and preeclampsia in home blood pressure monitoring: the existence of the inflection point and the rapid increased speed of blood pressure2012

    • Author(s)
      Takako Ohmaru, Akinori Miki, Kayo Takahashi, Akihide Ohkuchi, Atsuo Itakura, Shigeki Matsubara, Mitsuaki Suzuki
    • Organizer
      XVIII International Society for the Study of Hypertension in Pregnancy (ISSHP) World Congress
    • Place of Presentation
      Geneva
    • Related Report
      2012 Research-status Report
  • [Presentation] THE ADDITIVE EFFECT OF PLASMA LEVELS OF SFLT-1/PLGF RATIO FOLLOWING THE RISK CLASSIFICATION USING BOTH BLOOD PRESSURE LEVELS AND UTERINE ARTERY BLOOD FLOW IMPEDANCE IN THE SECOND TRIMESTER ON THE LATER OCCURRENCE OF PREECLAMPSIA2012

    • Author(s)
      Akihide Ohkuchi, Chikako Hirashima, Kayo Takahashi, Sigeki Matsubara, Mitsuaki Suzuki
    • Organizer
      XVIII International Society for the Study of Hypertension in Pregnancy (ISSHP) World Congress
    • Place of Presentation
      Geneva
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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