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Immunological analysis of immune-mediated pregnancy loss.

Research Project

Project/Area Number 24592485
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNihon University

Principal Investigator

AIZAWA Shihoko  日本大学, 医学部, 准教授 (30513858)

Co-Investigator(Kenkyū-buntansha) HAYAKAWA Satoshi  日本大学, 医学部, 教授 (30238084)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords不育症 / 流産 / 寄生虫 / 生殖免疫 / 制御性T細胞 / NK細胞 / 母児免疫寛容 / 自然リンパ球 / 制御性B細胞 / マウスモデル
Outline of Final Research Achievements

We previously reported recombinant Dirofilaria immitis polyproteins (rDiAg) treatment reduced the resorption rates of CBA/J×DBA/2J mouse model, which mimic human pregnancy failures with allo-immune backgrounds. In the present study, we examined possible immune-regulation of Nippostrongyls brasiliensis (Nb) which parasites mice as natural host. However the extract from Nb did not reduce abortion rate in the model system. Then we checked the intrauterine immune cells after administration of rDiAg and Saireito. Though importance of regulatory T cell (Treg) is well known to maintain pregnancy, no significant changes in Treg ratio were observed in both systems.Taken together, we suggest other regulatory cells for successful pregnancy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2012

All Presentation (2 results)

  • [Presentation] 生殖免疫学領域における動物モデル2014

    • Author(s)
      相澤志保子
    • Organizer
      日本臨床免疫学会
    • Place of Presentation
      京王プラザホテル(東京・新宿区)
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] アロ免疫による流産マウスモデルに対する新たな治療戦略と免疫学的解析2012

    • Author(s)
      相澤志保子、早川 智
    • Organizer
      第40回日本臨床免疫学会総会
    • Place of Presentation
      東京(新宿)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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