| Project/Area Number |
24592485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Satoshi 日本大学, 医学部, 教授 (30238084)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 不育症 / 流産 / 寄生虫 / 生殖免疫 / 制御性T細胞 / NK細胞 / 母児免疫寛容 / 自然リンパ球 / 制御性B細胞 / マウスモデル |
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| Outline of Final Research Achievements |
We previously reported recombinant Dirofilaria immitis polyproteins (rDiAg) treatment reduced the resorption rates of CBA/J×DBA/2J mouse model, which mimic human pregnancy failures with allo-immune backgrounds. In the present study, we examined possible immune-regulation of Nippostrongyls brasiliensis (Nb) which parasites mice as natural host. However the extract from Nb did not reduce abortion rate in the model system. Then we checked the intrauterine immune cells after administration of rDiAg and Saireito. Though importance of regulatory T cell (Treg) is well known to maintain pregnancy, no significant changes in Treg ratio were observed in both systems.Taken together, we suggest other regulatory cells for successful pregnancy.
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