| Project/Area Number |
24592486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHISHIMA Fumihisa 日本大学, 医学部, 准教授 (50277414)
KUNO Souichiro 日本大学, 医学部, 助教 (30350002)
ICHIKAWA Go 日本大学, 医学部, 助教 (80599994)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | PlGF / VEGF / sFlt-1 / HIF-1alpha / MTF-1 / HO-1 / sEndoglin / AT1-AA / 妊娠高血圧症候群 / 妊娠高血圧腎症 / placenta growth factor / ｓFlt-1 / 血清因子 / 低酸素応答分子 |
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| Outline of Final Research Achievements |
In order to investigate pathophysiology in preeclampsia, we studied the effect of preeclampsia sera on their expression from trophoblast derived cells and the expression of PlGF, sFlt-1,MTF-1,HO-1 and HIF-1α mRNAs in placenta taken from preeclampsia. The changes of PlGF mRNA in preeclampsia placenta may relate to serum factor and the expression of MTF-1 and HIF-αmRNA. The changes of sFlt-1mRNA may relate to serum factor and the expression of HIF-alpha mRNA. We suggested that not only hypoxia but also serum factor may play a role in the levels of PlGF and sFlt-1 in preeclampsia placenta.
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