IgG transport mechanism of Fc gamma RIIb-containing compartments across the placental barrier
| Project/Area Number |
24592489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ochanomizu University |
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Principal Investigator |
ISHIKAWA Tomoko お茶の水女子大学, プロジェクト教育研究院, 特任准教授 (70212850)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Yoko お茶の水女子大学, 基幹研究院, 教授 (50293105)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKIZAWA Toshihiro 日本医科大学, 大学院医学研究科, 教授 (90271220)
KIKUCHI Kunio 日本医科大学, 医学部, 講師 (70374676)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞・組織 / 小胞輸送 / 免疫 / 栄養 |
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| Outline of Final Research Achievements |
We performed in vitro bio-imaging analysis of IgG trafficking by FcγRIIb-containing compartments and elucidated that FcγRIIb participates in maternal IgG trafficking of placental endothelial cells and RAB3D plays a role in regulating intracellular dynamics of the FcγRIIb-containing compartments. Furthermore, we attempted to develop animal model and confirmed FcγRIIb expression level in hepatic sinusoidal endothelial cells during the diet-induced hepatic disorders.
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Report
(5 results)
Research Products
(9 results)
