| Project/Area Number |
24592493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Yuichiro 川崎医科大学, 医学部, 准教授 (50271193)
FUKE Shinji 川崎医科大学, 医学部, 講師 (50333696)
CHANG Yang-Sil 川崎医科大学, 医学部, 講師 (70565910)
TOMIMATSU Takuji 川崎医科大学, 医学部, 准教授 (30346209)
MURATA Takuya 川崎医科大学, 医学部, 講師 (20714207)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 酸化ストレス / 母体ストレス / 子宮筋 / 子宮収縮 / サイトカイン / 嗅覚 / ストレスマーカー / コルチゾール / 抗酸化力 |
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| Outline of Final Research Achievements |
Aromatherapy affected maternal stress level by HPA axis. Maternal stress levels also associated with maternal sexual function, maternal general health, EPDS and mother-to-infant bonding. Maternal oxidative stress levels were associated with uterine contraction and intrauterine infection. However, fetal oxidative stress levels were lower than those of mothers. Maternal anti-oxidative levels were low, but fetal levels were higher than adult levels. IL-8, IL-17, TNF-α, and IL-23 in maternal or cord blood were associated with uterine contraction.
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