| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Intrauterine growth retardation (IUGR) leads to low birth weight. Recent human studies have shown that IUGR is associated with learning disability and memory impairment. However, the interactions between IUGR and neurodevelopmental disorders remain unclear. In this study, we tested the hypothesis that IUGR would be caused by moderate food restriction in pregnant females and that the offspring would have neurodevelopmental disabilities. Mid-pregnant mice received moderate food restriction through the early lactation period. The results showed that IUGR offspring had low birth weight and delayed development of physical and coordinated movement. They also exhibited mental disabilities such as anxiety and poor cognitive function. Male offspring exhibited significantly impaired hippocampal synaptogenesis at 3 weeks of age. These results suggested that restricted maternal diet increases developmental disability in IUGR offspring and that male offspring might be especially susceptible.
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