| Project/Area Number |
24592496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hokkaido Cancer Center(Department of Clinical Research) (2013-2014)
Hokkaido University (2012) |
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Principal Investigator |
TODO Yukiharu 独立行政法人国立病院機構北海道がんセンター(臨床研究部), その他部局等, その他 (90374389)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAGI Noriaki 北海道大学, 医学(系)研究科(研究院), 教授 (70153963)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮体癌 / リンパ節転移 / 微小転移 / リンパ節微小転移 / 再発 / 予後 |
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| Outline of Final Research Achievements |
Lymph node (LN) micrometastases were detected in 14.8% of patients with intermediate-risk endometrial cancer. LN micrometastasis was an independent risk factor for extrapelvic recurrence [hazard risk (HR) 17.9, 95% confidence interval (CI) 1.4-232.2]. There was no significant difference in overall survival (log-rank test, P=0.074) between the node-negative and LN micrometastasis groups. However, the 8-year overall survival (OS) was >20% lower in the LN micrometastasis group than in the node-negative group (OS: 71.4% vs. 91.9%). Unfortunately, there were too few patients in our study to provide conclusive results. It remains unclear whether LN micrometastasis have an adverse influence on prognosis of intermediate-risk disease. In the near future, with the popularization of sentinel node mapping,a problem concerning how to treat with patients with LN micrometastases will occur. A multicenter cooperative study is needed to clarify the clinical significance of LN micrometastasis.
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