| Project/Area Number |
24592497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATARI Hidemichi 北海道大学, 北海道大学病院, 講師 (10344508)
SAKURAGI Noriaki 北海道大学, 大学院医学研究科, 教授 (70153963)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | cervical cancer / CIN / HPV / ZFP36 / IMP3 / 子宮頸癌 / ZFP-36 / 免疫組織化学 |
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| Outline of Final Research Achievements |
We aimed to examine the expression of RNA-binding proteins (IMP3 and ZFP36) in HPV-16-positive cervical intraepithelial neoplasia (CIN), and squamous cell carcinoma (SCC), and investigate whether their expression is correlated with disease progression of CIN2/3. Immunohistochemistry showed that higher expression of IMP3, lower expression of ZFP36 was more frequently observed in CIN3 and SCC than CIN1/2. Among CIN2/3, cases with higher IMP3 expression progressed to higher-grade lesions, whereas cases with lower IMP3 expression did not progress.We conclude that increased expression of IMP3 and/or reduced expression of ZFP36 may play a role in HPV-16-related cervical carcinogenesis. Immunohistochemical expression of IMP3 might be a useful marker to predict progression of HPV16-positive CIN2/3 to higher-grade lesions.
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