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Biological role of ZFP36 in gynecologic malignancies

Research Project

Project/Area Number 24592497
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHokkaido University

Principal Investigator

HOSAKA Masayoshi  北海道大学, 大学病院, 助教 (20374390)

Co-Investigator(Kenkyū-buntansha) WATARI Hidemichi  北海道大学, 北海道大学病院, 講師 (10344508)
SAKURAGI Noriaki  北海道大学, 大学院医学研究科, 教授 (70153963)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordscervical cancer / CIN / HPV / ZFP36 / IMP3 / 子宮頸癌 / ZFP-36 / 免疫組織化学
Outline of Final Research Achievements

We aimed to examine the expression of RNA-binding proteins (IMP3 and ZFP36) in HPV-16-positive cervical intraepithelial neoplasia (CIN), and squamous cell carcinoma (SCC), and investigate whether their expression is correlated with disease progression of CIN2/3. Immunohistochemistry showed that higher expression of IMP3, lower expression of ZFP36 was more frequently observed in CIN3 and SCC than CIN1/2. Among CIN2/3, cases with higher IMP3 expression progressed to higher-grade lesions, whereas cases with lower IMP3 expression did not progress.We conclude that increased expression of IMP3 and/or reduced expression of ZFP36 may play a role in HPV-16-related cervical carcinogenesis. Immunohistochemical expression of IMP3 might be a useful marker to predict progression of HPV16-positive CIN2/3 to higher-grade lesions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Multivariate prognostic analysis on the patients with adenocarcinoma of the uterine cervix treated with radical hysterectomy and systematic lymphadenectomy.2013

    • Author(s)
      Kato T, Watari H*,Takeda M, Hosaka M, Mitamura T, Kobayashi N, Sudo S, Kaneuchi M, Kudo M, Sakuragi N.
    • Journal Title

      Journal of Gynecologic Oncology

      Volume: 24 Issue: 3 Pages: 222-228

    • DOI

      10.3802/jgo.2013.24.3.222

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 子宮体がんにおけるリンパ節郭 清術の意義とその手技2013

    • Author(s)
      保坂昌芳、金内優典、渡利英道
    • Journal Title

      産婦人科の実際

      Volume: 62 Pages: 39-43

    • Related Report
      2013 Research-status Report
  • [Journal Article] Incidence risk of cervical intraepithelial neoplasia 3 or more severe lesions is a function of human papillomavirus genotypes and severity of cytological and histological abnormalities in adult Japanese women.2013

    • Author(s)
      Hosaka M, Fujita H, Hanley SJB, Sasaki T, Shirakawa Y, Abiko M, Kudo M, Kaneuchi M, Watari H, Kikuchi K, Sakuragi N.
    • Journal Title

      International Journal of Cancer

      Volume: 132 Issue: 2 Pages: 327-334

    • DOI

      10.1002/ijc.27680

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of paclitaxel/cisplatin as an adjuvant chemotherapy for patients with cervical cancer who underwent radical hysterectomy and systematic lymphadenecctomy2012

    • Author(s)
      Hosaka M, Watari H, Kato T, Odagiri T, Konno Y, Endo D, Mitamura T, Kikawa S, Suzuki Y, Sakuragi N.
    • Journal Title

      Journal of Surgical Oncology

      Volume: 105 Issue: 6 Pages: 612-616

    • DOI

      10.1002/jso.22136

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 子宮頚部異形成(CIN)の進展とIMP3、ZFP36発現との関連について2015

    • Author(s)
      嶋田知紗、保坂昌芳、渡利英道、山口正博、福本 俊、遠藤大介、井平 圭、金野陽輔、加藤達矢、工藤正尊、水上尚典、櫻木範明
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-04-10 – 2015-04-12
    • Related Report
      2014 Annual Research Report
  • [Book] OGS Now 13機能温存の手術―疾患治療と妊娠・性機能の予後に配慮して―2013

    • Author(s)
      渡利英道、保坂昌芳、櫻木範明
    • Total Pages
      168
    • Publisher
      メジカルビュー社
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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